ASIC4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ASIC4_HUMAN
• UniProt AC: Q96FT7
• Protein Name: Acid-sensing ion channel 4
• Gene Name: ASIC4
• Organism: Homo sapiens (Human).
• Sequence Length: 647
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Description: Probable cation channel with high affinity for sodium. In vitro, has no proton-gated channel activity..
• Protein Sequence: MLSGAAGAARRGGAALAPSLTRSLAGTHAGADSCAGADKGSHKETIEERDKRQQRQQRQRQHQGCGAAGSGSDSPTSGPHPVPVLFPLALSLEEQPLPPLPLGRAPGLLAREGQGREALASPSSRGQMPIEIVCKIKFAEEDAKPKEKEAGDEQSLLGAVAPGAAPRDLATFASTSTLHGLGRACGPGPHGLRRTLWALALLTSLAAFLYQAAGLARGYLTRPHLVAMDPAAPAPVAGFPAVTLCNINRFRHSALSDADIFHLANLTGLPPKDRDGHRAAGLRYPEPDMVDILNRTGHQLADMLKSCNFSGHHCSASNFSVVYTRYGKCYTFNADPRSSLPSRAGGMGSGLEIMLDIQQEEYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPWGNCRAESELREPELQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMPDSLGGGPEGPCFCPTPCNLTRYGKEISMVRIPNRGSARYLARKYNRNETYIRENFLVLDVFFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGASILTLLEILDYIYEVSWDRLKRVWRRPKTPLRTSTGGISTLGLQELKEQSPCPSRGRVEGGGVSSLLPNHHHPHGPPGGLFEDFAC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	Phosphorylation	GGAALAPSLTRSLAG CHHCCCCHHHHHHCC	36.44	22210691
21	Phosphorylation	AALAPSLTRSLAGTH HCCCCHHHHHHCCCC	23.66	21712546
23	Phosphorylation	LAPSLTRSLAGTHAG CCCHHHHHHCCCCCC	19.82	21712546
33	Phosphorylation	GTHAGADSCAGADKG CCCCCCHHCCCCCCC	12.82	21712546
318	N-linked_Glycosylation	GHHCSASNFSVVYTR CCCCCCCCCEEEEEE	32.69	UniProtKB CARBOHYD
330	Phosphorylation	YTRYGKCYTFNADPR EEECCEEEEECCCCC	20.18	-
331	Phosphorylation	TRYGKCYTFNADPRS EECCEEEEECCCCCC	21.63	-
370	N-linked_Glycosylation	LPIWRETNETSFEAG CCCEEECCCCCCCCE	45.88	UniProtKB CARBOHYD
484	N-linked_Glycosylation	CFCPTPCNLTRYGKE CCCCCCCCCEECCCE	45.72	UniProtKB CARBOHYD
493	Phosphorylation	TRYGKEISMVRIPNR EECCCEEEEEECCCC	16.59	24719451
502	Phosphorylation	VRIPNRGSARYLARK EECCCCHHHHHHHHH	13.31	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ASIC4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ASIC4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ASIC4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HSP7E_HUMAN	HSPA14	physical	28514442
TMM8A_HUMAN	TMEM8A	physical	28514442
ADCY3_HUMAN	ADCY3	physical	28514442
TM231_HUMAN	TMEM231	physical	28514442
CNNM1_HUMAN	CNNM1	physical	28514442
IPRI_HUMAN	ITPRIP	physical	28514442
ABCA3_HUMAN	ABCA3	physical	28514442
LRP12_HUMAN	LRP12	physical	28514442
GBRB3_HUMAN	GABRB3	physical	28514442
CLPT1_HUMAN	CLPTM1	physical	28514442
E2AK3_HUMAN	EIF2AK3	physical	28514442
TSN6_HUMAN	TSPAN6	physical	28514442
GLBL2_HUMAN	GLB1L2	physical	28514442
ALG9_HUMAN	ALG9	physical	28514442
OSBL8_HUMAN	OSBPL8	physical	28514442
AT2A3_HUMAN	ATP2A3	physical	28514442
MANEL_HUMAN	MANEAL	physical	28514442
FA69A_HUMAN	FAM69A	physical	28514442
GLRB_HUMAN	GLRB	physical	28514442
CISD2_HUMAN	CISD2	physical	28514442
BSCL2_HUMAN	BSCL2	physical	28514442
NETO2_HUMAN	NETO2	physical	28514442
UPK3L_HUMAN	UPK3BL	physical	28514442
ALG12_HUMAN	ALG12	physical	28514442
UFSP2_HUMAN	UFSP2	physical	28514442
LSR_HUMAN	LSR	physical	28514442
1C07_HUMAN	HLA-C	physical	28514442
1B07_HUMAN	HLA-B	physical	28514442
1B18_HUMAN	HLA-B	physical	28514442
BI1_HUMAN	TMBIM6	physical	28514442
CHSTA_HUMAN	CHST10	physical	28514442
TMPPE_HUMAN	TMPPE	physical	28514442
TMX2_HUMAN	TMX2	physical	28514442
TXD15_HUMAN	TXNDC15	physical	28514442
PMGT1_HUMAN	POMGNT1	physical	28514442
FBX2_HUMAN	FBXO2	physical	28514442
POMT2_HUMAN	POMT2	physical	28514442
TM206_HUMAN	TMEM206	physical	28514442
PDZD8_HUMAN	PDZD8	physical	28514442
SGPP1_HUMAN	SGPP1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.