FKBP6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FKBP6_HUMAN
• UniProt AC: O75344
• Protein Name: Inactive peptidyl-prolyl cis-trans isomerase FKBP6
• Gene Name: FKBP6
• Organism: Homo sapiens (Human).
• Sequence Length: 327
• Subcellular Localization: Cytoplasm, cytosol. Nucleus. Chromosome. Does not localize to pi-bodies. Localizes to meiotic chromosome cores and regions of homologous chromosome synapsis (By similarity)..
• Protein Description: Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes (By similarity)..
• Protein Sequence: MGGSALNQGVLEGDDAPGQSLYERLSQRMLDISGDRGVLKDVIREGAGDLVAPDASVLVKYSGYLEHMDRPFDSNYFRKTPRLMKLGEDITLWGMELGLLSMRRGELARFLFKPNYAYGTLGCPPLIPPNTTVLFEIELLDFLDCAESDKFCALSAEQQDQFPLQKVLKVAATEREFGNYLFRQNRFYDAKVRYKRALLLLRRRSAPPEEQHLVEAAKLPVLLNLSFTYLKLDRPTIALCYGEQALIIDQKNAKALFRCGQACLLLTEYQKARDFLVRAQKEQPFNHDINNELKKLASCYRDYVDKEKEMWHRMFAPCGDGSTAGES

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
101	Phosphorylation	GMELGLLSMRRGELA HHHHHHHHHCHHHHH	18.45	-
131	Phosphorylation	PPLIPPNTTVLFEIE CCCCCCCCEEEEEEE	24.85	-
148	Phosphorylation	DFLDCAESDKFCALS HHHHHHHCCCEEECC	27.81	-
188	Phosphorylation	LFRQNRFYDAKVRYK HHHHCCCCHHHHHHH	16.26	22817900
294	Acetylation	HDINNELKKLASCYR CCCHHHHHHHHHHHH	39.29	20167786

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FKBP6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FKBP6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FKBP6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NDK7_HUMAN	NME7	physical	16189514
CCNK_HUMAN	CCNK	physical	16189514
OSBP1_HUMAN	OSBP	physical	25036637
HS90B_HUMAN	HSP90AB1	physical	25036637
HS90A_HUMAN	HSP90AA1	physical	25036637
UBP19_HUMAN	USP19	physical	25036637
TEBP_HUMAN	PTGES3	physical	25036637
CDC37_HUMAN	CDC37	physical	25036637
PFD2_HUMAN	PFDN2	physical	25036637
PFD3_HUMAN	VBP1	physical	25036637
CK5P3_HUMAN	CDK5RAP3	physical	25416956
LZTS2_HUMAN	LZTS2	physical	25416956
IHO1_HUMAN	CCDC36	physical	25416956
RED_HUMAN	IK	physical	26186194
CD37L_HUMAN	CDC37L1	physical	26186194
RGPD5_HUMAN	RGPD5	physical	26186194
MYPT2_HUMAN	PPP1R12B	physical	26186194
MYPT1_HUMAN	PPP1R12A	physical	26186194
OSBP1_HUMAN	OSBP	physical	26186194
ANM3_HUMAN	PRMT3	physical	26186194
PPIL2_HUMAN	PPIL2	physical	26186194
WDCP_HUMAN	C2orf44	physical	26186194
UBP19_HUMAN	USP19	physical	26186194
SI1L1_HUMAN	SIPA1L1	physical	26186194
UBE3D_HUMAN	UBE3D	physical	26186194
GRDN_HUMAN	CCDC88A	physical	26186194
TBL1R_HUMAN	TBL1XR1	physical	26186194
TBL1X_HUMAN	TBL1X	physical	26186194
AGAP3_HUMAN	AGAP3	physical	26186194
ACOX3_HUMAN	ACOX3	physical	26186194
F118B_HUMAN	FAM118B	physical	26186194
EF2K_HUMAN	EEF2K	physical	26186194
OSBP1_HUMAN	OSBP	physical	28514442
CD37L_HUMAN	CDC37L1	physical	28514442
AGAP3_HUMAN	AGAP3	physical	28514442
EF2K_HUMAN	EEF2K	physical	28514442
MYPT1_HUMAN	PPP1R12A	physical	28514442
MYPT2_HUMAN	PPP1R12B	physical	28514442
UBP19_HUMAN	USP19	physical	28514442
RED_HUMAN	IK	physical	28514442
WDCP_HUMAN	C2orf44	physical	28514442
ACOX3_HUMAN	ACOX3	physical	28514442
ANM3_HUMAN	PRMT3	physical	28514442
PDE4A_HUMAN	PDE4A	physical	28514442
GRDN_HUMAN	CCDC88A	physical	28514442
F118B_HUMAN	FAM118B	physical	28514442
UBE3D_HUMAN	UBE3D	physical	28514442
SI1L1_HUMAN	SIPA1L1	physical	28514442
PPIL2_HUMAN	PPIL2	physical	28514442
TBL1R_HUMAN	TBL1XR1	physical	28514442
TBL1X_HUMAN	TBL1X	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.