GALT5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GALT5_HUMAN
• UniProt AC: Q7Z7M9
• Protein Name: Polypeptide N-acetylgalactosaminyltransferase 5
• Gene Name: GALNT5
• Organism: Homo sapiens (Human).
• Sequence Length: 940
• Subcellular Localization: Golgi apparatus membrane; Single-pass type II membrane protein.
• Protein Description: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward EA2 peptide substrate, but has a weak activity toward Muc2 or Muc1b substrates (By similarity)..
• Protein Sequence: MNRIRKFFRGSGRVLAFIFVASVIWLLFDMAALRLSFSEINTRVIKEDIVRRERIGFRVQPDQGKIFYSSIKEMKPPLRGHGKGAWGKENVRKTEESVLKVEVDLDQTQRERKMQNALGRGKVVPLWHPAHLQTLPVTPNKQKTDGRGTKPEASSHQGTPKQTTAQGAPKTSFIAAKGTQVVKISVHMGRVSLKQEPRKSHSPSSDTSKLAAERDLNVTISLSTDRPKQRSQAVANERAHPASTAVPKSGEAMALNKTKTQSKEVNANKHKANTSLPFPKFTVNSNRLRKQSINETPLGSLSKDDGARGAHGKKLNFSESHLVIITKEEEQKADPKEVSNSKTKTIFPKVLGKSQSKHISRNRSEMSSSSLAPHRVPLSQTNHALTGGLEPAKINITAKAPSTEYNQSHIKALLPEDSGTHQVLRIDVTLSPRDPKAPGQFGRPVVVPHGKEKEAERRWKEGNFNVYLSDLIPVDRAIEDTRPAGCAEQLVHNNLPTTSVIMCFVDEVWSTLLRSVHSVINRSPPHLIKEILLVDDFSTKDYLKDNLDKYMSQFPKVRILRLKERHGLIRARLAGAQNATGDVLTFLDSHVECNVGWLEPLLERVYLSRKKVACPVIEVINDKDMSYMTVDNFQRGIFVWPMNFGWRTIPPDVIAKNRIKETDTIRCPVMAGGLFSIDKSYFFELGTYDPGLDVWGGENMELSFKVWMCGGEIEIIPCSRVGHIFRNDNPYSFPKDRMKTVERNLVRVAEVWLDEYKELFYGHGDHLIDQGLDVGNLTQQRELRKKLKCKSFKWYLENVFPDLRAPIVRASGVLINVALGKCISIENTTVILEDCDGSKELQQFNYTWLRLIKCGEWCIAPIPDKGAVRLHPCDNRNKGLKWLHKSTSVFHPELVNHIVFENNQQLLCLEGNFSQKILKVAACDPVKPYQKWKFEKYYEA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
68	Phosphorylation	PDQGKIFYSSIKEMK CCCCCEEEEHHHHCC	12.65	-
69	O-linked_Glycosylation	DQGKIFYSSIKEMKP CCCCEEEEHHHHCCC	18.16	55835187
69	Phosphorylation	DQGKIFYSSIKEMKP CCCCEEEEHHHHCCC	18.16	23186163
70	O-linked_Glycosylation	QGKIFYSSIKEMKPP CCCEEEEHHHHCCCC	26.71	62174395
70	Phosphorylation	QGKIFYSSIKEMKPP CCCEEEEHHHHCCCC	26.71	23917254
94	O-linked_Glycosylation	GKENVRKTEESVLKV CHHHHCCCHHHEEEE	34.13	55825205
108	O-linked_Glycosylation	VEVDLDQTQRERKMQ EEECCHHHHHHHHHH	29.30	55832927
122	Ubiquitination	QNALGRGKVVPLWHP HHHHCCCCEECCCCC	38.40	-
134	O-linked_Glycosylation	WHPAHLQTLPVTPNK CCCCCEEECCCCCCC	39.11	55826971
138	O-linked_Glycosylation	HLQTLPVTPNKQKTD CEEECCCCCCCCCCC	21.14	55826977
149	O-linked_Glycosylation	QKTDGRGTKPEASSH CCCCCCCCCCCCCCC	41.90	55824853
154	O-linked_Glycosylation	RGTKPEASSHQGTPK CCCCCCCCCCCCCCC	27.05	55824857
154	Phosphorylation	RGTKPEASSHQGTPK CCCCCCCCCCCCCCC	27.05	22210691
155	O-linked_Glycosylation	GTKPEASSHQGTPKQ CCCCCCCCCCCCCCC	27.20	55824863
159	O-linked_Glycosylation	EASSHQGTPKQTTAQ CCCCCCCCCCCCCCC	22.27	55824869
163	O-linked_Glycosylation	HQGTPKQTTAQGAPK CCCCCCCCCCCCCCC	30.17	55824873
164	O-linked_Glycosylation	QGTPKQTTAQGAPKT CCCCCCCCCCCCCCC	17.94	55824877
171	Phosphorylation	TAQGAPKTSFIAAKG CCCCCCCCEEEEECC	28.01	22210691
172	Phosphorylation	AQGAPKTSFIAAKGT CCCCCCCEEEEECCC	22.30	22210691
185	O-linked_Glycosylation	GTQVVKISVHMGRVS CCEEEEEEEEECCCC	10.55	OGP
192	O-linked_Glycosylation	SVHMGRVSLKQEPRK EEEECCCCCCCCCCC	28.61	46217893
192	Phosphorylation	SVHMGRVSLKQEPRK EEEECCCCCCCCCCC	28.61	-
200	O-linked_Glycosylation	LKQEPRKSHSPSSDT CCCCCCCCCCCCCCH	30.40	46217897
200	Phosphorylation	LKQEPRKSHSPSSDT CCCCCCCCCCCCCCH	30.40	27251275
202	O-linked_Glycosylation	QEPRKSHSPSSDTSK CCCCCCCCCCCCHHH	33.30	55830279
202	Phosphorylation	QEPRKSHSPSSDTSK CCCCCCCCCCCCHHH	33.30	-
204	O-linked_Glycosylation	PRKSHSPSSDTSKLA CCCCCCCCCCHHHHH	43.81	55830283
204	Phosphorylation	PRKSHSPSSDTSKLA CCCCCCCCCCHHHHH	43.81	-
205	O-linked_Glycosylation	RKSHSPSSDTSKLAA CCCCCCCCCHHHHHH	48.57	55830289
205	Phosphorylation	RKSHSPSSDTSKLAA CCCCCCCCCHHHHHH	48.57	-
207	Phosphorylation	SHSPSSDTSKLAAER CCCCCCCHHHHHHHH	29.70	-
207	O-linked_Glycosylation	SHSPSSDTSKLAAER CCCCCCCHHHHHHHH	29.70	55830295
208	O-linked_Glycosylation	HSPSSDTSKLAAERD CCCCCCHHHHHHHHC	30.57	55830301
217	N-linked_Glycosylation	LAAERDLNVTISLST HHHHHCCCEEEEEEC	32.92	UniProtKB CARBOHYD
249	Phosphorylation	ASTAVPKSGEAMALN CCCCCCCCCCCCCCC	35.48	26270265
256	N-linked_Glycosylation	SGEAMALNKTKTQSK CCCCCCCCCCCCCCC	40.17	UniProtKB CARBOHYD
262	Phosphorylation	LNKTKTQSKEVNANK CCCCCCCCCCCCCCC	35.69	26699800
273	N-linked_Glycosylation	NANKHKANTSLPFPK CCCCCCCCCCCCCCC	34.70	UniProtKB CARBOHYD
274	O-linked_Glycosylation	ANKHKANTSLPFPKF CCCCCCCCCCCCCCC	36.18	55835799
275	O-linked_Glycosylation	NKHKANTSLPFPKFT CCCCCCCCCCCCCCE	33.58	55835803
292	Phosphorylation	SNRLRKQSINETPLG CCHHCCCCCCCCCCC	30.34	26434776
292	O-linked_Glycosylation	SNRLRKQSINETPLG CCHHCCCCCCCCCCC	30.34	37604085
296	Phosphorylation	RKQSINETPLGSLSK CCCCCCCCCCCCCCC	21.23	26434776
296	O-linked_Glycosylation	RKQSINETPLGSLSK CCCCCCCCCCCCCCC	21.23	37604091
300	Phosphorylation	INETPLGSLSKDDGA CCCCCCCCCCCCCCC	36.83	20393185
300	O-linked_Glycosylation	INETPLGSLSKDDGA CCCCCCCCCCCCCCC	36.83	37604097
302	Phosphorylation	ETPLGSLSKDDGARG CCCCCCCCCCCCCCC	35.42	-
302	O-linked_Glycosylation	ETPLGSLSKDDGARG CCCCCCCCCCCCCCC	35.42	55823845
314	Acetylation	ARGAHGKKLNFSESH CCCCCCCCCCCCCCC	53.94	7825277
316	N-linked_Glycosylation	GAHGKKLNFSESHLV CCCCCCCCCCCCCEE	47.48	UniProtKB CARBOHYD
318	Phosphorylation	HGKKLNFSESHLVII CCCCCCCCCCCEEEE	36.80	28509920
320	Phosphorylation	KKLNFSESHLVIITK CCCCCCCCCEEEEEH	22.41	28509920
326	Phosphorylation	ESHLVIITKEEEQKA CCCEEEEEHHHHHCC	22.68	28509920
354	Phosphorylation	FPKVLGKSQSKHISR HHHHHCCHHHHHHHC	37.58	29449344
362	N-linked_Glycosylation	QSKHISRNRSEMSSS HHHHHHCCHHHCCCC	45.07	UniProtKB CARBOHYD
379	O-linked_Glycosylation	APHRVPLSQTNHALT CCCCCCHHHCCCCCC	28.96	55827837
381	O-linked_Glycosylation	HRVPLSQTNHALTGG CCCCHHHCCCCCCCC	26.12	55827843
386	O-linked_Glycosylation	SQTNHALTGGLEPAK HHCCCCCCCCCCCEE	29.95	55827847
395	N-linked_Glycosylation	GLEPAKINITAKAPS CCCCEEEEEEEECCC	25.50	UniProtKB CARBOHYD
402	Phosphorylation	NITAKAPSTEYNQSH EEEEECCCCCCCHHH	38.44	30576142
403	Phosphorylation	ITAKAPSTEYNQSHI EEEECCCCCCCHHHH	41.24	30576142
405	Phosphorylation	AKAPSTEYNQSHIKA EECCCCCCCHHHHHH	20.70	29255136
406	N-linked_Glycosylation	KAPSTEYNQSHIKAL ECCCCCCCHHHHHHH	30.55	UniProtKB CARBOHYD
408	Phosphorylation	PSTEYNQSHIKALLP CCCCCCHHHHHHHCC	24.44	29255136
420	O-linked_Glycosylation	LLPEDSGTHQVLRID HCCCCCCCCEEEEEE	17.06	55835121
429	O-linked_Glycosylation	QVLRIDVTLSPRDPK EEEEEEEEECCCCCC	20.12	55824277
429	Phosphorylation	QVLRIDVTLSPRDPK EEEEEEEEECCCCCC	20.12	25022875
431	Phosphorylation	LRIDVTLSPRDPKAP EEEEEEECCCCCCCC	14.44	24719451
529	Acetylation	RSPPHLIKEILLVDD CCCCHHHEEEEEECC	45.09	7676485
578	N-linked_Glycosylation	ARLAGAQNATGDVLT HHHCCCCCCCCCHHH	38.65	UniProtKB CARBOHYD
610	Acetylation	ERVYLSRKKVACPVI HHHHHCCCCEECEEE	48.50	7408225
611	Acetylation	RVYLSRKKVACPVIE HHHHCCCCEECEEEE	33.67	7408235
623	Acetylation	VIEVINDKDMSYMTV EEEEECCCCCCEEEE	51.33	7408245
664	Phosphorylation	NRIKETDTIRCPVMA CCCCCCCCEECCEEC	20.10	-
703	Phosphorylation	GGENMELSFKVWMCG CCCCCEEEEEEEECC	15.09	24719451
776	N-linked_Glycosylation	DQGLDVGNLTQQREL CCCCCCCCHHHHHHH	39.50	UniProtKB CARBOHYD
795	Phosphorylation	KCKSFKWYLENVFPD CCHHHHHHHHHHCCC	12.53	-
827	N-linked_Glycosylation	GKCISIENTTVILED CCEEEEECEEEEEEC	39.10	UniProtKB CARBOHYD
845	N-linked_Glycosylation	SKELQQFNYTWLRLI CHHHHCCCCEEEEEE	29.05	UniProtKB CARBOHYD
912	N-linked_Glycosylation	QLLCLEGNFSQKILK EEEEEECCHHHHHHH	24.83	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GALT5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GALT5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GALT5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IF_HUMAN	GIF	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.