| UniProt ID | UD3A2_HUMAN | |
|---|---|---|
| UniProt AC | Q3SY77 | |
| Protein Name | UDP-glucuronosyltransferase 3A2 | |
| Gene Name | UGT3A2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 523 | |
| Subcellular Localization |
Membrane Single-pass type I membrane protein . |
|
| Protein Description | UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).. | |
| Protein Sequence | MAGQRVLLLVGFLLPGVLLSEAAKILTISTVGGSHYLLMDRVSQILQDHGHNVTMLNHKRGPFMPDFKKEEKSYQVISWLAPEDHQREFKKSFDFFLEETLGGRGKFENLLNVLEYLALQCSHFLNRKDIMDSLKNENFDMVIVETFDYCPFLIAEKLGKPFVAILSTSFGSLEFGLPIPLSYVPVFRSLLTDHMDFWGRVKNFLMFFSFCRRQQHMQSTFDNTIKEHFTEGSRPVLSHLLLKAELWFINSDFAFDFARPLLPNTVYVGGLMEKPIKPVPQDLENFIAKFGDSGFVLVTLGSMVNTCQNPEIFKEMNNAFAHLPQGVIWKCQCSHWPKDVHLAANVKIVDWLPQSDLLAHPSIRLFVTHGGQNSIMEAIQHGVPMVGIPLFGDQPENMVRVEAKKFGVSIQLKKLKAETLALKMKQIMEDKRYKSAAVAASVILRSHPLSPTQRLVGWIDHVLQTGGATHLKPYVFQQPWHEQYLLDVFVFLLGLTLGTLWLCGKLLGMAVWWLRGARKVKET | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 27 (in isoform 2) | Phosphorylation | - | 19.16 | 30631047 | |
| 29 (in isoform 2) | Phosphorylation | - | 16.29 | 30631047 | |
| 30 (in isoform 2) | Phosphorylation | - | 21.22 | 30631047 | |
| 36 | Phosphorylation | STVGGSHYLLMDRVS ECCCCHHHHHHHHHH | 11.83 | - | |
| 43 | Phosphorylation | YLLMDRVSQILQDHG HHHHHHHHHHHHHCC | 16.64 | - | |
| 52 | N-linked_Glycosylation | ILQDHGHNVTMLNHK HHHHCCCCEEEECCC | 35.23 | UniProtKB CARBOHYD | |
| 128 | Acetylation | CSHFLNRKDIMDSLK HHHHCCHHHHHHHHH | 51.00 | 7824087 | |
| 135 | Acetylation | KDIMDSLKNENFDMV HHHHHHHHCCCCCEE | 67.19 | 7824097 | |
| 362 | Phosphorylation | SDLLAHPSIRLFVTH HHHHCCCEEEEEEEC | 15.52 | 24719451 | |
| 425 | Ubiquitination | ETLALKMKQIMEDKR HHHHHHHHHHHCCCC | 34.78 | - | |
| 433 | Phosphorylation | QIMEDKRYKSAAVAA HHHCCCCHHHHHHHH | 18.29 | 27251275 | |
| 435 | Phosphorylation | MEDKRYKSAAVAASV HCCCCHHHHHHHHHH | 16.72 | 27251275 | |
| 441 | Phosphorylation | KSAAVAASVILRSHP HHHHHHHHHHHHHCC | 10.43 | 28176443 | |
| 446 | Phosphorylation | AASVILRSHPLSPTQ HHHHHHHHCCCCHHH | 26.47 | 28176443 | |
| 450 | Phosphorylation | ILRSHPLSPTQRLVG HHHHCCCCHHHHHHH | 30.28 | 28176443 | |
| 452 | Phosphorylation | RSHPLSPTQRLVGWI HHCCCCHHHHHHHHH | 23.97 | 28176443 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of UD3A2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of UD3A2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of UD3A2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| THIL_HUMAN | ACAT1 | physical | 26344197 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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