RNF6_HUMAN - dbPTM
RNF6_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RNF6_HUMAN
UniProt AC Q9Y252
Protein Name E3 ubiquitin-protein ligase RNF6
Gene Name RNF6
Organism Homo sapiens (Human).
Sequence Length 685
Subcellular Localization Nucleus . Cytoplasm . Cell projection, axon. Nucleus, PML body. Localizes to the PML nuclear bodies in Sertoli cells..
Protein Description E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator..
Protein Sequence MNQSRSRSDGGSEETLPQDHNHHENERRWQQERLHREEAYYQFINELNDEDYRLMRDHNLLGTPGEITSEELQQRLDGVKEQLASQPDLRDGTNYRDSEVPRESSHEDSLLEWLNTFRRTGNATRSGQNGNQTWRAVSRTNPNNGEFRFSLEIHVNHENRGFEIHGEDYTDIPLSDSNRDHTANRQQRSTSPVARRTRSQTSVNFNGSSSNIPRTRLASRGQNPAEGSFSTLGRLRNGIGGAAGIPRANASRTNFSSHTNQSGGSELRQREGQRFGAAHVWENGARSNVTVRNTNQRLEPIRLRSTSNSRSRSPIQRQSGTVYHNSQRESRPVQQTTRRSVRRRGRTRVFLEQDRERERRGTAYTPFSNSRLVSRITVEEGEESSRSSTAVRRHPTITLDLQVRRIRPGENRDRDSIANRTRSRVGLAENTVTIESNSGGFRRTISRLERSGIRTYVSTITVPLRRISENELVEPSSVALRSILRQIMTGFGELSSLMEADSESELQRNGQHLPDMHSELSNLGTDNNRSQHREGSSQDRQAQGDSTEMHGENETTQPHTRNSDSRGGRQLRNPNNLVETGTLPILRLAHFFLLNESDDDDRIRGLTKEQIDNLSTRHYEHNSIDSELGKICSVCISDYVTGNKLRQLPCMHEFHIHCIDRWLSENCTCPICRQPVLGSNIANNG
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6Phosphorylation--MNQSRSRSDGGSE
--CCCCCCCCCCCCC		41.19-
40PhosphorylationRLHREEAYYQFINEL
HHHHHHHHHHHHHHC		10.9027642862
41PhosphorylationLHREEAYYQFINELN
HHHHHHHHHHHHHCC		12.1927642862
52PhosphorylationNELNDEDYRLMRDHN
HHCCHHHHHHHHHCC		12.0027642862
80UbiquitinationQQRLDGVKEQLASQP
HHHHHHHHHHHHCCC		45.3221906983
85PhosphorylationGVKEQLASQPDLRDG
HHHHHHHCCCCCCCC		51.3327499020
104PhosphorylationDSEVPRESSHEDSLL
CCCCCCCCCCHHHHH		37.9728122231
105PhosphorylationSEVPRESSHEDSLLE
CCCCCCCCCHHHHHH		26.5828122231
109PhosphorylationRESSHEDSLLEWLNT
CCCCCHHHHHHHHHH		31.6928122231
133PhosphorylationSGQNGNQTWRAVSRT
CCCCCCCCEEEEEEE		22.40-
189PhosphorylationTANRQQRSTSPVARR
CCCHHHHCCCCCHHH		28.9728102081
190PhosphorylationANRQQRSTSPVARRT
CCHHHHCCCCCHHHC		38.9624719451
191PhosphorylationNRQQRSTSPVARRTR
CHHHHCCCCCHHHCC		20.7228102081
199PhosphorylationPVARRTRSQTSVNFN
CCHHHCCCCCEEECC		36.8822210691
201PhosphorylationARRTRSQTSVNFNGS
HHHCCCCCEEECCCC		35.5729116813
210PhosphorylationVNFNGSSSNIPRTRL
EECCCCCCCCCCCHH		40.2422210691
220MethylationPRTRLASRGQNPAEG
CCCHHHHCCCCCCCC		45.14115491439
236MethylationFSTLGRLRNGIGGAA
CHHHHHHCCCCCCCC		37.66115389485
247MethylationGGAAGIPRANASRTN
CCCCCCCCCCCCCCC		38.25115389491
252UbiquitinationIPRANASRTNFSSHT
CCCCCCCCCCCCCCC		31.14-
253PhosphorylationPRANASRTNFSSHTN
CCCCCCCCCCCCCCC		37.8122210691
265PhosphorylationHTNQSGGSELRQREG
CCCCCCCCHHHHHCC		36.6622210691
288UbiquitinationWENGARSNVTVRNTN
HCCCCCCCEEECCCC		28.11-
305PhosphorylationLEPIRLRSTSNSRSR
CEEEEEEECCCCCCC		40.5629449344
306PhosphorylationEPIRLRSTSNSRSRS
EEEEEEECCCCCCCC		26.0328509920
307PhosphorylationPIRLRSTSNSRSRSP
EEEEEECCCCCCCCC		33.7728509920
309PhosphorylationRLRSTSNSRSRSPIQ
EEEECCCCCCCCCCC		31.2528509920
311PhosphorylationRSTSNSRSRSPIQRQ
EECCCCCCCCCCCCC		36.6127794612
313PhosphorylationTSNSRSRSPIQRQSG
CCCCCCCCCCCCCCC		27.8327794612
323PhosphorylationQRQSGTVYHNSQRES
CCCCCCEEECCCCCC		8.6328122231
326PhosphorylationSGTVYHNSQRESRPV
CCCEEECCCCCCCCC		19.8028122231
330PhosphorylationYHNSQRESRPVQQTT
EECCCCCCCCCCHHH		44.0326074081
336PhosphorylationESRPVQQTTRRSVRR
CCCCCCHHHHHHHHH		12.7426074081
337PhosphorylationSRPVQQTTRRSVRRR
CCCCCHHHHHHHHHH		21.5326074081
340PhosphorylationVQQTTRRSVRRRGRT
CCHHHHHHHHHHCCE		19.3826074081
362PhosphorylationRERERRGTAYTPFSN
HHHHHCCCCCCCCCC		18.0628152594
364PhosphorylationRERRGTAYTPFSNSR
HHHCCCCCCCCCCCE		18.1328152594
365PhosphorylationERRGTAYTPFSNSRL
HHCCCCCCCCCCCEE		18.5228152594
368PhosphorylationGTAYTPFSNSRLVSR
CCCCCCCCCCEEEEE		34.7928152594
370PhosphorylationAYTPFSNSRLVSRIT
CCCCCCCCEEEEEEE		26.2829978859
374PhosphorylationFSNSRLVSRITVEEG
CCCCEEEEEEEEECC		23.6629978859
377PhosphorylationSRLVSRITVEEGEES
CEEEEEEEEECCCCC		22.2830576142
384PhosphorylationTVEEGEESSRSSTAV
EEECCCCCCCCCCCH		27.0930576142
387PhosphorylationEGEESSRSSTAVRRH
CCCCCCCCCCCHHHC		33.7129978859
388PhosphorylationGEESSRSSTAVRRHP
CCCCCCCCCCHHHCC		21.1929978859
389PhosphorylationEESSRSSTAVRRHPT
CCCCCCCCCHHHCCE		30.3429978859
396PhosphorylationTAVRRHPTITLDLQV
CCHHHCCEEEEEEEE		22.0729978859
398PhosphorylationVRRHPTITLDLQVRR
HHHCCEEEEEEEEEE		19.3929978859
459PhosphorylationGIRTYVSTITVPLRR
CCEEEEEEEEEECCC		15.6021712546
461PhosphorylationRTYVSTITVPLRRIS
EEEEEEEEEECCCCC		19.0321712546
468PhosphorylationTVPLRRISENELVEP
EEECCCCCCCCCCCH		32.3427174698
476PhosphorylationENELVEPSSVALRSI
CCCCCCHHHHHHHHH		24.7627174698
477PhosphorylationNELVEPSSVALRSIL
CCCCCHHHHHHHHHH		23.3327174698
482PhosphorylationPSSVALRSILRQIMT
HHHHHHHHHHHHHHH		27.1627174698
546PhosphorylationDRQAQGDSTEMHGEN
HHHHHCCCCCCCCCC		32.84-
547PhosphorylationRQAQGDSTEMHGENE
HHHHCCCCCCCCCCC		41.91-
597PhosphorylationHFFLLNESDDDDRIR
HHHHCCCCCCCHHHC		45.3124719451
608UbiquitinationDRIRGLTKEQIDNLS
HHHCCCCHHHHHHCH		53.3021906983
623PhosphorylationTRHYEHNSIDSELGK
HHCCCCCCHHHHHHH		29.6726714015
626PhosphorylationYEHNSIDSELGKICS
CCCCCHHHHHHHHHH		32.8126714015
644UbiquitinationSDYVTGNKLRQLPCM
HHHCCCCCHHHCCCC		46.52-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RNF6_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RNF6_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RNF6_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ANDR_HUMANARphysical
19345326
UB2D1_HUMANUBE2D1physical
19345326
LOX5_HUMANALOX5physical
28514442
VASN_HUMANVASNphysical
28514442
ASAH1_HUMANASAH1physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
133239Esophageal cancer (ESCR)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RNF6_HUMAN

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Related Literatures of Post-Translational Modification

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