ASXL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ASXL1_HUMAN
• UniProt AC: Q8IXJ9
• Protein Name: Putative Polycomb group protein ASXL1
• Gene Name: ASXL1
• Organism: Homo sapiens (Human).
• Sequence Length: 1541
• Subcellular Localization: Nucleus .
• Protein Description: Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator of RARA and RXRA through association with NCOA1. Acts as corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity (By similarity). Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1)..
• Protein Sequence: MKDKQKKKKERTWAEAARLVLENYSDAPMTPKQILQVIEAEGLKEMRSGTSPLACLNAMLHSNSRGGEGLFYKLPGRISLFTLKKDALQWSRHPATVEGEEPEDTADVESCGSNEASTVSGENDVSLDETSSNASCSTESQSRPLSNPRDSYRASSQANKQKKKTGVMLPRVVLTPLKVNGAHVESASGFSGCHADGESGSPSSSSSGSLALGSAAIRGQAEVTQDPAPLLRGFRKPATGQMKRNRGEEIDFETPGSILVNTNLRALINSRTFHALPSHFQQQLLFLLPEVDRQVGTDGLLRLSSSALNNEFFTHAAQSWRERLADGEFTHEMQVRIRQEMEKEKKVEQWKEKFFEDYYGQKLGLTKEESLQQNVGQEEAEIKSGLCVPGESVRIQRGPATRQRDGHFKKRSRPDLRTRARRNLYKKQESEQAGVAKDAKSVASDVPLYKDGEAKTDPAGLSSPHLPGTSSAAPDLEGPEFPVESVASRIQAEPDNLARASASPDRIPSLPQETVDQEPKDQKRKSFEQAASASFPEKKPRLEDRQSFRNTIESVHTEKPQPTKEEPKVPPIRIQLSRIKPPWVVKGQPTYQICPRIIPTTESSCRGWTGARTLADIKARALQVRGARGHHCHREAATTAIGGGGGPGGGGGGATDEGGGRGSSSGDGGEACGHPEPRGGPSTPGKCTSDLQRTQLLPPYPLNGEHTQAGTAMSRARREDLPSLRKEESCLLQRATVGLTDGLGDASQLPVAPTGDQPCQALPLLSSQTSVAERLVEQPQLHPDVRTECESGTTSWESDDEEQGPTVPADNGPIPSLVGDDTLEKGTGQALDSHPTMKDPVNVTPSSTPESSPTDCLQNRAFDDELGLGGSCPPMRESDTRQENLKTKALVSNSSLHWIPIPSNDEVVKQPKPESREHIPSVEPQVGEEWEKAAPTPPALPGDLTAEEGLDPLDSLTSLWTVPSRGGSDSNGSYCQQVDIEKLKINGDSEALSPHGESTDTASDFEGHLTEDSSEADTREAAVTKGSSVDKDEKPNWNQSAPLSKVNGDMRLVTRTDGMVAPQSWVSRVCAVRQKIPDSLLLASTEYQPRAVCLSMPGSSVEATNPLVMQLLQGSLPLEKVLPPAHDDSMSESPQVPLTKDQSHGSLRMGSLHGLGKNSGMVDGSSPSSLRALKEPLLPDSCETGTGLARIEATQAPGAPQKNCKAVPSFDSLHPVTNPITSSRKLEEMDSKEQFSSFSCEDQKEVRAMSQDSNSNAAPGKSPGDLTTSRTPRFSSPNVISFGPEQTGRALGDQSNVTGQGKKLFGSGNVAATLQRPRPADPMPLPAEIPPVFPSGKLGPSTNSMSGGVQTPREDWAPKPHAFVGSVKNEKTFVGGPLKANAENRKATGHSPLELVGHLEGMPFVMDLPFWKLPREPGKGLSEPLEPSSLPSQLSIKQAFYGKLSKLQLSSTSFNYSSSSPTFPKGLAGSVVQLSHKANFGASHSASLSLQMFTDSSTVESISLQCACSLKAMIMCQGCGAFCHDDCIGPSKLCVLCLVVR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
30	Phosphorylation	NYSDAPMTPKQILQV HCCCCCCCHHHHHHH	26.69	-
48	Phosphorylation	EGLKEMRSGTSPLAC CCHHHHHCCCCHHHH	45.15	27080861
50	Phosphorylation	LKEMRSGTSPLACLN HHHHHCCCCHHHHHH	28.55	27080861
51	Phosphorylation	KEMRSGTSPLACLNA HHHHCCCCHHHHHHH	22.80	22199227
164	Acetylation	QANKQKKKTGVMLPR HHHHHHHCCCCCCCE	58.51	12433735
175	Phosphorylation	MLPRVVLTPLKVNGA CCCEEEEEEEEECCE	18.24	21815630
186	Phosphorylation	VNGAHVESASGFSGC ECCEEEECCCCCCCC	27.01	24275569
188	Phosphorylation	GAHVESASGFSGCHA CEEEECCCCCCCCCC	50.04	24275569
199	Phosphorylation	GCHADGESGSPSSSS CCCCCCCCCCCCCCC	50.53	24275569
199	O-linked_Glycosylation	GCHADGESGSPSSSS CCCCCCCCCCCCCCC	50.53	21740066
201	Phosphorylation	HADGESGSPSSSSSG CCCCCCCCCCCCCCC	30.78	27050516
204	Phosphorylation	GESGSPSSSSSGSLA CCCCCCCCCCCCCCH	37.31	24275569
205	Phosphorylation	ESGSPSSSSSGSLAL CCCCCCCCCCCCCHH	32.62	22817900
304	Phosphorylation	TDGLLRLSSSALNNE CCHHHHCCHHHHCCH	18.80	-
351 (in isoform 1)	Ubiquitination	-	51.20	21890473
351 (in isoform 2)	Ubiquitination	-	51.20	21890473
351	Ubiquitination	EKKVEQWKEKFFEDY HHHHHHHHHHHHHHH	51.20	21906983
353	Ubiquitination	KVEQWKEKFFEDYYG HHHHHHHHHHHHHHH	52.18	-
362	Ubiquitination	FEDYYGQKLGLTKEE HHHHHHHHHCCCHHH	39.91	21890473
362 (in isoform 1)	Ubiquitination	-	39.91	21890473
362 (in isoform 2)	Ubiquitination	-	39.91	21890473
367	Ubiquitination	GQKLGLTKEESLQQN HHHHCCCHHHHHHHH	65.61	21906983
367 (in isoform 1)	Ubiquitination	-	65.61	21890473
367 (in isoform 2)	Ubiquitination	-	65.61	21890473
401	Phosphorylation	RIQRGPATRQRDGHF EEEECCCHHCCCCCC	30.39	23403867
449	Phosphorylation	VASDVPLYKDGEAKT HHCCCCCCCCCCCCC	10.85	-
456	Phosphorylation	YKDGEAKTDPAGLSS CCCCCCCCCCCCCCC	55.02	27080861
462	Phosphorylation	KTDPAGLSSPHLPGT CCCCCCCCCCCCCCC	40.69	27080861
463	Phosphorylation	TDPAGLSSPHLPGTS CCCCCCCCCCCCCCC	22.75	28450419
469	Phosphorylation	SSPHLPGTSSAAPDL CCCCCCCCCCCCCCC	19.98	28450419
470	Phosphorylation	SPHLPGTSSAAPDLE CCCCCCCCCCCCCCC	24.72	27080861
471	Phosphorylation	PHLPGTSSAAPDLEG CCCCCCCCCCCCCCC	28.43	27080861
501	Phosphorylation	PDNLARASASPDRIP CCCHHHCCCCCCCCC	24.59	30266825
503	Phosphorylation	NLARASASPDRIPSL CHHHCCCCCCCCCCC	25.49	30266825
509	Phosphorylation	ASPDRIPSLPQETVD CCCCCCCCCCHHHCC	50.76	30266825
514	Phosphorylation	IPSLPQETVDQEPKD CCCCCHHHCCCCCHH	24.92	23403867
526	Phosphorylation	PKDQKRKSFEQAASA CHHHHHHHHHHHHHC	37.74	22199227
532	Phosphorylation	KSFEQAASASFPEKK HHHHHHHHCCCCCCC	27.71	28985074
557	Phosphorylation	NTIESVHTEKPQPTK HHHHHHHCCCCCCCC	43.48	-
577	Phosphorylation	PPIRIQLSRIKPPWV CCEEEEEEECCCCEE	18.65	24719451
606	Methylation	PTTESSCRGWTGART CCCCCCCCCCCCCCC	45.70	-
723	Phosphorylation	ARREDLPSLRKEESC HHHHHCHHHCHHHHH	48.37	24719451
844	Phosphorylation	MKDPVNVTPSSTPES CCCCCCCCCCCCCCC	16.55	-
909	Ubiquitination	PSNDEVVKQPKPESR CCCCCCCCCCCCCCC	67.09	-
936	Phosphorylation	EWEKAAPTPPALPGD HHHHHCCCCCCCCCC	36.86	28348404
989	Phosphorylation	KLKINGDSEALSPHG ECEECCCCCCCCCCC	26.60	22210691
999	Phosphorylation	LSPHGESTDTASDFE CCCCCCCCCCHHHHC	32.82	22210691
1010	Phosphorylation	SDFEGHLTEDSSEAD HHHCCCCCCCCCCCH	31.88	22210691
1025	Acetylation	TREAAVTKGSSVDKD HHHHHHHCCCCCCCC	50.63	18527295
1056	Phosphorylation	DMRLVTRTDGMVAPQ CEEEEECCCCCCCCH	27.78	23403867
1064	Phosphorylation	DGMVAPQSWVSRVCA CCCCCCHHHHHHHHH	28.52	-
1067	Phosphorylation	VAPQSWVSRVCAVRQ CCCHHHHHHHHHHHH	16.85	23403867
1143	Phosphorylation	VPLTKDQSHGSLRMG CCCCCCCCCCCEECC	39.69	20815410
1151	Phosphorylation	HGSLRMGSLHGLGKN CCCEECCCCCCCCCC	14.09	23532336
1159	Phosphorylation	LHGLGKNSGMVDGSS CCCCCCCCCCCCCCC	31.58	23532336
1165	Phosphorylation	NSGMVDGSSPSSLRA CCCCCCCCCHHHHHH	34.31	25627689
1166	Phosphorylation	SGMVDGSSPSSLRAL CCCCCCCCHHHHHHH	34.04	25627689
1168	Phosphorylation	MVDGSSPSSLRALKE CCCCCCHHHHHHHCC	43.91	22964224
1169	Phosphorylation	VDGSSPSSLRALKEP CCCCCHHHHHHHCCC	25.84	22964224
1174	Ubiquitination	PSSLRALKEPLLPDS HHHHHHHCCCCCCCC	57.19	-
1194	Phosphorylation	GLARIEATQAPGAPQ CCEEEEECCCCCCCC	16.69	-
1209	Phosphorylation	KNCKAVPSFDSLHPV CCCCCCCCCCCCCCC	34.78	-
1250	Phosphorylation	QKEVRAMSQDSNSNA HHHHHHHHCCCCCCC	29.83	-
1253	Phosphorylation	VRAMSQDSNSNAAPG HHHHHCCCCCCCCCC	34.22	-
1262	Phosphorylation	SNAAPGKSPGDLTTS CCCCCCCCCCCCCCC	39.78	-
1276	Phosphorylation	SRTPRFSSPNVISFG CCCCCCCCCCEEECC	20.13	-
1302	Acetylation	SNVTGQGKKLFGSGN CCCCCCCCCCCCCCC	38.11	26051181
1341	Phosphorylation	PSGKLGPSTNSMSGG CCCCCCCCCCCCCCC	38.12	-
1344	Phosphorylation	KLGPSTNSMSGGVQT CCCCCCCCCCCCCCC	17.89	-
1371	Ubiquitination	VGSVKNEKTFVGGPL ECCCCCCEEEECCCC	57.57	-
1379	Ubiquitination	TFVGGPLKANAENRK EEECCCCCCCCCCCC	42.61	-
1419	Ubiquitination	KLPREPGKGLSEPLE CCCCCCCCCCCCCCC	68.35	-
1437 (in isoform 1)	Ubiquitination	-	32.00	21890473
1437	Ubiquitination	LPSQLSIKQAFYGKL CCCCHHHHHHHHHCC	32.00	2190698
1443	Ubiquitination	IKQAFYGKLSKLQLS HHHHHHHCCCCCEEE	37.90	-
1446	Ubiquitination	AFYGKLSKLQLSSTS HHHHCCCCCEEECCC	51.17	-
1494	Phosphorylation	SLSLQMFTDSSTVES EEEEEECCCCCCCCH	29.63	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ASXL1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ASXL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ASXL1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AKT1_HUMAN	AKT1	physical	18624398
BAP1_HUMAN	BAP1	physical	21642991
A4_HUMAN	APP	physical	21832049
EZH2_HUMAN	EZH2	physical	22897849
EED_HUMAN	EED	physical	22897849
STAT3_HUMAN	STAT3	physical	21988832
OGT1_HUMAN	OGT	physical	26416890
HCFC1_HUMAN	HCFC1	physical	26416890
FOXK1_HUMAN	FOXK1	physical	26416890
FOXK2_HUMAN	FOXK2	physical	26416890

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• 605039: Bohring-Opitz syndrome (BOPS)
• 614286: Myelodysplastic syndrome (MDS)
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.