EFCB6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EFCB6_HUMAN
• UniProt AC: Q5THR3
• Protein Name: EF-hand calcium-binding domain-containing protein 6
• Gene Name: EFCAB6
• Organism: Homo sapiens (Human).
• Sequence Length: 1501
• Subcellular Localization: Nucleus .
• Protein Description: Negatively regulates the androgen receptor by recruiting histone deacetylase complex, and protein DJ-1 antagonizes this inhibition by abrogation of this complex..
• Protein Sequence: MCKMAIIPDWLRSHPHTRKFTHSRPHSSPCRVYSRNGSPNKFRSSSTTAVANPTLSSLDVKRILFQKITDRGDELQKAFQLLDTGQNLTVSKSELRRIITDFLMPLTREQFQDVLAQIPLSTSGTVPYLAFLSRFGGIDLYINGIKRGGGNEMNCCRTLRELEIQVGEKVFKNIKTVMKAFELIDVNKTGLVRPQELRRVLETFCMKLRDEEYEKFSKHYNIHKDTAVDYNVFLKNLSINNDLNLRYCMGNQEVSLENQQAKNSKKERLLGSASSEDIWRNYSLDEIERNFCLQLSKSYEKVEKALSAGDPCKGGYVSFNYLKIVLDTFVYQIPRRIFIQLMKRFGLKATTKINWKQFLTSFHEPQGLQVSSKGPLTKRNSINSRNESHKENIITKLFRHTEDHSASLKKALLIINTKPDGPITREEFRYILNCMAVKLSDSEFKELMQMLDPGDTGVVNTSMFIDLIEENCRMRKTSPCTDAKTPFLLAWDSVEEIVHDTITRNLQAFYNMLRSYDLGDTGRIGRNNFKKIMHVFCPFLTNAHFIKLCSKIQDIGSGRILYKKLLACIGIDGPPTVSPVLVPKDQLLSEHLQKDEQQQPDLSERTKLTEDKTTLTKKMTTEEVIEKFKKCIQQQDPAFKKRFLDFSKEPNGKINVHDFKKVLEDTGMPMDDDQYALLTTKIGFEKEGMSYLDFAAGFEDPPMRGPETTPPQPPTPSKSYVNSHFITAEECLKLFPRRLKESFRDPYSAFFKTDADRDGIINMHDLHRLLLHLLLNLKDDEFERFLGLLGLRLSVTLNFREFQNLCEKRPWRTDEAPQRLIRPKQKVADSELACEQAHQYLVTKAKNRWSDLSKNFLETDNEGNGILRRRDIKNALYGFDIPLTPREFEKLWARYDTEGKGHITYQEFLQKLGINYSPAVHRPCAEDYFNFMGHFTKPQQLQEEMKELQQSTEKAVAARDKLMDRHQDISKAFTKTDQSKTNYISICKMQEVLEECGCSLTEGELTHLLNSWGVSRHDNAINYLDFLRAVENSKSTGAQPKEKEESMPINFATLNPQEAVRKIQEVVESSQLALSTAFSALDKEDTGFVKATEFGQVLKDFCYKLTDNQYHYFLRKLRIHLTPYINWKYFLQNFSCFLEETADEWAEKMPKGPPPTSPKATADRDILARLHKAVTSHYHAITQEFENFDTMKTNTISREEFRAICNRRVQILTDEQFDRLWNEMPVNAKGRLKYPDFLSRFSSETAATPMATGDSAVAQRGSSVPDVSEGTRSALSLPTQELRPGSKSQSHPCTPASTTVIPGTPPLQNCDPIESRLRKRIQGCWRQLLKECKEKDVARQGDINASDFLALVEKFNLDISKEECQQLIIKYDLKSNGKFAYCDFIQSCVLLLKAKESSLMHRMKIQNAHKMKEAGAETPSFYSALLRIQPKIVHCWRPMRRTFKSYDEAGTGLLSVADFRTVLRQYSINLSEEEFFHILEYYDKTLSSKISYNDFLRAFLQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6 (in isoform 2)	Phosphorylation	-	4.14	19664994
44	Phosphorylation	GSPNKFRSSSTTAVA CCCCCCCCCCCCCCC	31.60	30622161
45	Phosphorylation	SPNKFRSSSTTAVAN CCCCCCCCCCCCCCC	27.70	30622161
46	Phosphorylation	PNKFRSSSTTAVANP CCCCCCCCCCCCCCC	30.90	30622161
47	Phosphorylation	NKFRSSSTTAVANPT CCCCCCCCCCCCCCC	22.26	30622161
48	Phosphorylation	KFRSSSTTAVANPTL CCCCCCCCCCCCCCC	22.53	30622161
54	Phosphorylation	TTAVANPTLSSLDVK CCCCCCCCCCHHCHH	38.79	30622161
56	Phosphorylation	AVANPTLSSLDVKRI CCCCCCCCHHCHHHH	31.19	30622161
57	Phosphorylation	VANPTLSSLDVKRIL CCCCCCCHHCHHHHH	31.53	30622161
107	Phosphorylation	TDFLMPLTREQFQDV HHHHHHCCHHHHHHH	26.70	-
158	Phosphorylation	NEMNCCRTLRELEIQ CCCCCCHHHHHHHHH	19.09	19664994
169	Acetylation	LEIQVGEKVFKNIKT HHHHHHHHHHHHHHH	47.22	69283
172	Acetylation	QVGEKVFKNIKTVMK HHHHHHHHHHHHHHH	61.83	69801
175	Acetylation	EKVFKNIKTVMKAFE HHHHHHHHHHHHHHH	44.45	69287
179	Acetylation	KNIKTVMKAFELIDV HHHHHHHHHHHHCCC	45.66	69803
188	Acetylation	FELIDVNKTGLVRPQ HHHCCCCCCCCCCHH	43.76	69291
272	Phosphorylation	KKERLLGSASSEDIW HHHHHHCCCCHHHHH	25.58	24114839
274	Phosphorylation	ERLLGSASSEDIWRN HHHHCCCCHHHHHHC	35.64	24114839
275	Phosphorylation	RLLGSASSEDIWRNY HHHCCCCHHHHHHCC	38.72	30622161
282	Phosphorylation	SEDIWRNYSLDEIER HHHHHHCCCHHHHHH	11.31	29083192
283	Phosphorylation	EDIWRNYSLDEIERN HHHHHCCCHHHHHHH	32.66	30622161
296	O-linked_Glycosylation	RNFCLQLSKSYEKVE HHHHHHHHHCHHHHH	13.44	30620550
297	Acetylation	NFCLQLSKSYEKVEK HHHHHHHHCHHHHHH	66.70	7340191
298	Phosphorylation	FCLQLSKSYEKVEKA HHHHHHHCHHHHHHH	34.84	30631047
301	Acetylation	QLSKSYEKVEKALSA HHHHCHHHHHHHHHC	47.67	7340203
377	Phosphorylation	VSSKGPLTKRNSINS ECCCCCCCCCCCCCC	30.96	20860994
388	Phosphorylation	SINSRNESHKENIIT CCCCCCHHHHHHHHH	43.33	30622161
395	Phosphorylation	SHKENIITKLFRHTE HHHHHHHHHHHHCCC	20.21	30622161
424	Phosphorylation	TKPDGPITREEFRYI CCCCCCCCHHHHHHH	34.85	-
442	Phosphorylation	MAVKLSDSEFKELMQ HHEECCHHHHHHHHH	41.37	26029660
510	Phosphorylation	TRNLQAFYNMLRSYD HHHHHHHHHHHHHCC	11.59	22817900
521	Phosphorylation	RSYDLGDTGRIGRNN HHCCCCCCCCCCCCH	26.93	-
576	Phosphorylation	IGIDGPPTVSPVLVP HCCCCCCCCCCCCCC	36.43	25693802
578	Phosphorylation	IDGPPTVSPVLVPKD CCCCCCCCCCCCCHH	16.27	30622161
589	Phosphorylation	VPKDQLLSEHLQKDE CCHHHHHHHHHHHHH	31.40	30622161
594	Acetylation	LLSEHLQKDEQQQPD HHHHHHHHHHHHCCC	70.37	25038526
613	Phosphorylation	TKLTEDKTTLTKKMT HCCCCCCHHHHCCCC	39.08	29083192
614	Phosphorylation	KLTEDKTTLTKKMTT CCCCCCHHHHCCCCH	37.86	29083192
616	Phosphorylation	TEDKTTLTKKMTTEE CCCCHHHHCCCCHHH	26.90	29083192
620	Phosphorylation	TTLTKKMTTEEVIEK HHHHCCCCHHHHHHH	39.68	29083192
621	Phosphorylation	TLTKKMTTEEVIEKF HHHCCCCHHHHHHHH	27.01	29083192
647	Phosphorylation	KKRFLDFSKEPNGKI HHHHHCCCCCCCCCC	35.46	-
675	Phosphorylation	MPMDDDQYALLTTKI CCCCHHHHHHHEEEE	13.25	22817900
690	Phosphorylation	GFEKEGMSYLDFAAG CCCCCCCCHHHHCCC	33.14	30622161
691	Phosphorylation	FEKEGMSYLDFAAGF CCCCCCCHHHHCCCC	11.03	30622161
708	Phosphorylation	PPMRGPETTPPQPPT CCCCCCCCCCCCCCC	47.97	30622161
709	Phosphorylation	PMRGPETTPPQPPTP CCCCCCCCCCCCCCC	31.17	30622161
715	Phosphorylation	TTPPQPPTPSKSYVN CCCCCCCCCCHHHCC	47.05	30622161
717	Phosphorylation	PPQPPTPSKSYVNSH CCCCCCCCHHHCCCC	36.39	30622161
719	Phosphorylation	QPPTPSKSYVNSHFI CCCCCCHHHCCCCCC	38.35	25693802
720	Phosphorylation	PPTPSKSYVNSHFIT CCCCCHHHCCCCCCC	13.85	25693802
723	Phosphorylation	PSKSYVNSHFITAEE CCHHHCCCCCCCHHH	15.10	25693802
727	Phosphorylation	YVNSHFITAEECLKL HCCCCCCCHHHHHHH	27.37	25693802
877	Phosphorylation	RDIKNALYGFDIPLT HHHCHHHCCCCCCCC	17.21	-
884	Phosphorylation	YGFDIPLTPREFEKL CCCCCCCCHHHHHHH	18.23	24945436
911	Acetylation	TYQEFLQKLGINYSP EHHHHHHHHCCCCCC	51.32	19811747
952	Phosphorylation	MKELQQSTEKAVAAR HHHHHHHHHHHHHHH	36.85	26657352
970	Phosphorylation	MDRHQDISKAFTKTD HHHHHHHHHHHHHCC	26.65	28509920
985	Phosphorylation	QSKTNYISICKMQEV CCCCCCEEHHHHHHH	16.15	30631047
1046	Phosphorylation	QPKEKEESMPINFAT CCCCCHHCCCCCCCC	30.83	30631047
1129	Phosphorylation	TPYINWKYFLQNFSC CCCCCHHHHHHHCHH	10.92	29978859
1135	Phosphorylation	KYFLQNFSCFLEETA HHHHHHCHHHHHHHH	16.12	29978859
1141	Phosphorylation	FSCFLEETADEWAEK CHHHHHHHHHHHHHH	29.99	29978859
1156	Phosphorylation	MPKGPPPTSPKATAD CCCCCCCCCCCCCCC	64.53	30622161
1157	Phosphorylation	PKGPPPTSPKATADR CCCCCCCCCCCCCCH	30.12	30622161
1161	Phosphorylation	PPTSPKATADRDILA CCCCCCCCCCHHHHH	34.91	30622161
1175	Phosphorylation	ARLHKAVTSHYHAIT HHHHHHHHHHHHHHH	18.04	-
1176	Phosphorylation	RLHKAVTSHYHAITQ HHHHHHHHHHHHHHH	18.56	-
1178	Phosphorylation	HKAVTSHYHAITQEF HHHHHHHHHHHHHHH	7.85	-
1192	Acetylation	FENFDTMKTNTISRE HHCCCCCCCCCCCHH	40.49	25038526
1242	Phosphorylation	PDFLSRFSSETAATP HHHHHHCCCCCCCCC	26.59	25693802
1243	Phosphorylation	DFLSRFSSETAATPM HHHHHCCCCCCCCCC	35.93	25693802
1245	Phosphorylation	LSRFSSETAATPMAT HHHCCCCCCCCCCCC	24.44	24425749
1248	Phosphorylation	FSSETAATPMATGDS CCCCCCCCCCCCCCC	15.90	23532336
1252	Phosphorylation	TAATPMATGDSAVAQ CCCCCCCCCCCHHHH	34.96	25693802
1255	Phosphorylation	TPMATGDSAVAQRGS CCCCCCCCHHHHCCC	26.45	25693802
1262	Phosphorylation	SAVAQRGSSVPDVSE CHHHHCCCCCCCCCH	30.28	30622161
1263	Phosphorylation	AVAQRGSSVPDVSEG HHHHCCCCCCCCCHH	40.26	30622161
1268	Phosphorylation	GSSVPDVSEGTRSAL CCCCCCCCHHCCCHH	37.37	30622161
1271	Phosphorylation	VPDVSEGTRSALSLP CCCCCHHCCCHHCCC	19.87	25693802
1273	Phosphorylation	DVSEGTRSALSLPTQ CCCHHCCCHHCCCCC	33.14	30622161
1276	Phosphorylation	EGTRSALSLPTQELR HHCCCHHCCCCCCCC	31.83	30622161
1279	Phosphorylation	RSALSLPTQELRPGS CCHHCCCCCCCCCCC	39.71	30622161
1286	Phosphorylation	TQELRPGSKSQSHPC CCCCCCCCCCCCCCC	31.64	30622161
1288	Phosphorylation	ELRPGSKSQSHPCTP CCCCCCCCCCCCCCC	38.32	25693802
1290	Phosphorylation	RPGSKSQSHPCTPAS CCCCCCCCCCCCCCC	36.17	25693802
1294	Phosphorylation	KSQSHPCTPASTTVI CCCCCCCCCCCCEEE	26.75	25693802
1297	Phosphorylation	SHPCTPASTTVIPGT CCCCCCCCCEEECCC	26.30	25693802
1298	Phosphorylation	HPCTPASTTVIPGTP CCCCCCCCEEECCCC	27.47	25693802
1299	Phosphorylation	PCTPASTTVIPGTPP CCCCCCCEEECCCCC	17.59	25693802
1304	Phosphorylation	STTVIPGTPPLQNCD CCEEECCCCCCCCCC	19.17	25693802
1315	Phosphorylation	QNCDPIESRLRKRIQ CCCCHHHHHHHHHHH	37.02	25693802
1360	Phosphorylation	EKFNLDISKEECQQL HHCCCCCCHHHHHHH	33.41	29116813
1418	Phosphorylation	MKEAGAETPSFYSAL HHHCCCCCHHHHHHH	24.57	25693802
1420	Phosphorylation	EAGAETPSFYSALLR HCCCCCHHHHHHHHH	44.21	25693802
1423	Phosphorylation	AETPSFYSALLRIQP CCCHHHHHHHHHHCC	15.49	25693802

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EFCB6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EFCB6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EFCB6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PARK7_HUMAN	PARK7	physical	12612053
ANDR_HUMAN	AR	physical	12612053
HDAC1_HUMAN	HDAC1	physical	12612053
SIN3A_HUMAN	SIN3A	physical	12612053

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.