UBP26_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBP26_HUMAN
• UniProt AC: Q9BXU7
• Protein Name: Ubiquitin carboxyl-terminal hydrolase 26
• Gene Name: USP26
• Organism: Homo sapiens (Human).
• Sequence Length: 913
• Subcellular Localization: Nucleus .
• Protein Description: Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome (By similarity). Deubiquitinates the androgen receptor and regulates the androgen receptor signaling pathway..
• Protein Sequence: MAALFLRGFVQIGNCKTGISKSKEAFIEAVERKKKDRLVLYFKSGKYSTFRLSDNIQNVVLKSYRGNQNHLHLTLQNNNGLFIEGLSSTDAEQLKIFLDRVHQNEVQPPVRPGKGGSVFSSTTQKEINKTSFHKVDEKSSSKSFEIAKGSGTGVLQRMPLLTSKLTLTCGELSENQHKKRKRMLSSSSEMNEEFLKENNSVEYKKSKADCSRCVSYNREKQLKLKELEENKKLECESSCIMNATGNPYLDDIGLLQALTEKMVLVFLLQQGYSDGYTKWDKLKLFFELFPEKICHGLPNLGNTCYMNAVLQSLLSIPSFADDLLNQSFPWGKIPLNALTMCLARLLFFKDTYNIEIKEMLLLNLKKAISAAAEIFHGNAQNDAHEFLAHCLDQLKDNMEKLNTIWKPKSEFGEDNFPKQVFADDPDTSGFSCPVITNFELELLHSIACKACGQVILKTELNNYLSINLPQRIKAHPSSIQSTFDLFFGAEELEYKCAKCEHKTSVGVHSFSRLPRILIVHLKRYSLNEFCALKKNDQEVIISKYLKVSSHCNEGTRPPLPLSEDGEITDFQLLKVIRKMTSGNISVSWPATKESKDILAPHIGSDKESEQKKGQTVFKGASRRQQQKYLGKNSKPNELESVYSGDRAFIEKEPLAHLMTYLEDTSLCQFHKAGGKPASSPGTPLSKVDFQTVPENPKRKKYVKTSKFVAFDRIINPTKDLYEDKNIRIPERFQKVSEQTQQCDGMRICEQAPQQALPQSFPKPGTQGHTKNLLRPTKLNLQKSNRNSLLALGSNKNPRNKDILDKIKSKAKETKRNDDKGDHTYRLISVVSHLGKTLKSGHYICDAYDFEKQIWFTYDDMRVLGIQEAQMQEDRRCTGYIFFYMHNEIFEEMLKREENAQLNSKEVEETLQKE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
117	Phosphorylation	VRPGKGGSVFSSTTQ CCCCCCCCCCCCCCC	28.76	29759185
134	Acetylation	INKTSFHKVDEKSSS CCCCCCEECCCCCCC	49.74	7709849
186	Phosphorylation	KRKRMLSSSSEMNEE HHHHHHHCCHHHHHH	33.64	23403867
187	Phosphorylation	RKRMLSSSSEMNEEF HHHHHHCCHHHHHHH	27.26	23403867
188	Phosphorylation	KRMLSSSSEMNEEFL HHHHHCCHHHHHHHH	42.69	23403867
203	Phosphorylation	KENNSVEYKKSKADC HHCCCCCHHHCHHHH	22.89	-
352	Phosphorylation	LLFFKDTYNIEIKEM HHHCCCCCCCCHHHH	25.03	25690035
574	Ubiquitination	ITDFQLLKVIRKMTS CCHHHHHHHHHHHCC	44.18	-
615	Phosphorylation	SEQKKGQTVFKGASR HHHHHCCCCHHHCCH	36.26	-
739	Phosphorylation	FQKVSEQTQQCDGMR HHHHHHHHHCCCCCC	19.29	22210691
776	O-linked_Glycosylation	TKNLLRPTKLNLQKS HHCCCCCCCCCCCCC	41.55	30379171
795	Ubiquitination	LLALGSNKNPRNKDI CHHHCCCCCCCCHHH	70.76	30230243
805	Ubiquitination	RNKDILDKIKSKAKE CCHHHHHHHHHHHHH	48.89	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UBP26_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UBP26_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBP26_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
U17L7_HUMAN	USP17L7	physical	19615732
ANDR_HUMAN	AR	physical	27089915
MDM2_HUMAN	MDM2	physical	27810359
ZEB1_HUMAN	ZEB1	physical	29119051
RING1_MOUSE	Ring1	physical	28839133
PCGF2_MOUSE	Pcgf2	physical	28839133
CBX6_MOUSE	Cbx6	physical	28839133
CBX4_MOUSE	Cbx4	physical	28839133
CBX6_HUMAN	CBX6	physical	28839133
CBX4_HUMAN	CBX4	physical	28839133
CBX7_MOUSE	Cbx7	physical	28839133

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.