CBX6_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CBX6_MOUSE
• UniProt AC: Q9DBY5
• Protein Name: Chromobox protein homolog 6
• Gene Name: Cbx6
• Organism: Mus musculus (Mouse).
• Sequence Length: 414
• Subcellular Localization: Nucleus . Chromosome . Localizes to the inactivated X chromosome in females.
• Protein Description: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin (By similarity). Recruitment to chromatin might occur in an H3K27me3-independent fashion. [PubMed: 22226355]
• Protein Sequence: MELSAVGERVFAAESIIKRRIRKGRIEYLVKWKGWAIKYSTWEPEENILDSRLIAAFEQKERERELYGPKKRGPKPKTFLLKARAQAEALRISDVHFSVKPSASASSPKLHSSAAVHRLKKDIRRCHRMSRRPLPRPDPQGGSPGLRPPISPFSETVRIINRKVKPREPKRNRIILNLKVIDKGPGGGSTAQGTGALARPKVPSRNRVIGKSKKFSESMLRTQIRHMKFGTFALYKPPPAPLAPSTAGKADVASSGPGLLLATPAAAPFDAHSSSSSGCPSPTLQSSDPDDAPPKLLPETLSRSVPNWRESEVLDLSIPPEAAATGQRVPPDVTGAADQALHTALEPTGAGSSEPEAGDWRPEMSPCSNVVVTDVTSNLLTVTIKEFCSPEDFEKVAAGVAGATGGGGGTGPSK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
100	Acetylation	SDVHFSVKPSASASS CEEEEECCCCCCCCC	31.86	12656483
102	Phosphorylation	VHFSVKPSASASSPK EEEECCCCCCCCCCC	29.19	25619855
104	Phosphorylation	FSVKPSASASSPKLH EECCCCCCCCCCCCC	32.78	25619855
106	Phosphorylation	VKPSASASSPKLHSS CCCCCCCCCCCCCCH	44.68	25619855
107	Phosphorylation	KPSASASSPKLHSSA CCCCCCCCCCCCCHH	26.27	25619855
143	Phosphorylation	RPDPQGGSPGLRPPI CCCCCCCCCCCCCCC	23.71	27717184
151	Phosphorylation	PGLRPPISPFSETVR CCCCCCCCCCHHHHH	26.18	25338131
218	Phosphorylation	KSKKFSESMLRTQIR CCHHCCHHHHHHHHH	23.17	24453211
236	Ubiquitination	FGTFALYKPPPAPLA CCEEEEECCCCCCCC	52.47	-
249	Ubiquitination	LAPSTAGKADVASSG CCCCCCCCCCHHHCC	38.66	-
254	Phosphorylation	AGKADVASSGPGLLL CCCCCHHHCCCCEEE	35.36	25777480
255	Phosphorylation	GKADVASSGPGLLLA CCCCHHHCCCCEEEE	38.99	25777480
263	Phosphorylation	GPGLLLATPAAAPFD CCCEEEECCCCCCCC	17.27	25777480
273	Phosphorylation	AAPFDAHSSSSSGCP CCCCCCCCCCCCCCC	33.37	25777480
274	Phosphorylation	APFDAHSSSSSGCPS CCCCCCCCCCCCCCC	25.11	25777480
275	Phosphorylation	PFDAHSSSSSGCPSP CCCCCCCCCCCCCCC	31.38	25777480
276	Phosphorylation	FDAHSSSSSGCPSPT CCCCCCCCCCCCCCC	32.47	25777480
277	Phosphorylation	DAHSSSSSGCPSPTL CCCCCCCCCCCCCCC	46.49	25777480
281	Phosphorylation	SSSSGCPSPTLQSSD CCCCCCCCCCCCCCC	34.29	21183079
283	Phosphorylation	SSGCPSPTLQSSDPD CCCCCCCCCCCCCCC	41.59	25777480
286	Phosphorylation	CPSPTLQSSDPDDAP CCCCCCCCCCCCCCC	39.56	25777480
287	Phosphorylation	PSPTLQSSDPDDAPP CCCCCCCCCCCCCCC	39.95	25777480
404	Phosphorylation	AAGVAGATGGGGGTG HHHHCCCCCCCCCCC	35.13	20139300

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CBX6_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CBX6_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CBX6_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CBX6_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.