PWP2B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PWP2B_HUMAN
• UniProt AC: Q6NUJ5
• Protein Name: PWWP domain-containing protein 2B
• Gene Name: PWWP2B
• Organism: Homo sapiens (Human).
• Sequence Length: 590
• Protein Sequence: MEPRAGCRLPVRVEQVVNGALVVTVSCGERSFAGILLDCTKKSGLFGLPPLAPLPQVDESPVNDSHGRAPEEGDAEVMQLGSSSPPPARGVQPPETTRPEPPPPLVPPLPAGSLPPYPPYFEGAPFPHPLWLRDTYKLWVPQPPPRTIKRTRRRLSRNRDPGRLILSTIRLRPRQVLCEKCKSTLSPPEASPGPPAAPRARRRLGSGPDRELRKPEEPENGEPTAAATARRSKRERREEDRAPAEQVPRSPVIKISYSTPQGKGEVVKIPSRVHGSLEPFRPQQAPQDDGSQDPEVLDRESRDRPSCAPSASIPKLKLTRPVPAGADLPPPKIRLKPHRLGDSEHEPVYRAELVGELNGYLRDSSPAPCADGPAGGLADLSSGSSGEDDDFKSCPQGPQGREGLAFLVSCPEGRADCASESACSSDSLDEARSSGSEGTPADTGDLSPGHGASAPSVSREARQTVPPLTVRLHTQSVSECITEDGRTVAVGDIVWGKIHGFPWWPARVLDISLGQKEDGEPSWREAKVSWFGSPTTSFLSISKLSPFSEFFKLRFNRKKKGMYRKAITEAANAARHVAPEIRELLTQFET

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
43	Phosphorylation	LLDCTKKSGLFGLPP EEECCCCCCCCCCCC	42.14	-
60	Phosphorylation	PLPQVDESPVNDSHG CCCCCCCCCCCCCCC	29.68	25849741
65	Phosphorylation	DESPVNDSHGRAPEE CCCCCCCCCCCCCCC	23.72	22210691
82	Phosphorylation	AEVMQLGSSSPPPAR CCHHCCCCCCCCCCC	35.91	23401153
83	Phosphorylation	EVMQLGSSSPPPARG CHHCCCCCCCCCCCC	45.10	26657352
84	Phosphorylation	VMQLGSSSPPPARGV HHCCCCCCCCCCCCC	43.02	26657352
167	Phosphorylation	DPGRLILSTIRLRPR CCCCEEEEEEECCCH	18.13	20068231
168	Phosphorylation	PGRLILSTIRLRPRQ CCCEEEEEEECCCHH	13.48	20068231
183	Phosphorylation	VLCEKCKSTLSPPEA HHHHHHHHCCCCCCC	44.01	22199227
184	Phosphorylation	LCEKCKSTLSPPEAS HHHHHHHCCCCCCCC	19.42	22199227
186	Phosphorylation	EKCKSTLSPPEASPG HHHHHCCCCCCCCCC	38.20	25159151
191	Phosphorylation	TLSPPEASPGPPAAP CCCCCCCCCCCCCCH	28.82	25159151
206	Phosphorylation	RARRRLGSGPDRELR HHHHHCCCCCCHHHC	52.31	27794612
250	Phosphorylation	PAEQVPRSPVIKISY CHHHCCCCCEEEEEE	19.90	23401153
256	Phosphorylation	RSPVIKISYSTPQGK CCCEEEEEEECCCCC	14.18	26852163
257	Phosphorylation	SPVIKISYSTPQGKG CCEEEEEEECCCCCC	21.75	26852163
258	Phosphorylation	PVIKISYSTPQGKGE CEEEEEEECCCCCCC	27.16	25159151
259	Phosphorylation	VIKISYSTPQGKGEV EEEEEEECCCCCCCE	16.05	25159151
271	Phosphorylation	GEVVKIPSRVHGSLE CCEEECCCCCCCCCC	50.86	20068231
276	Phosphorylation	IPSRVHGSLEPFRPQ CCCCCCCCCCCCCCC	18.06	25159151
291	Phosphorylation	QAPQDDGSQDPEVLD CCCCCCCCCCHHHHC	38.10	17525332
312	Phosphorylation	PSCAPSASIPKLKLT CCCCCCCCCCCCEEC	43.70	28555341
360	Phosphorylation	LVGELNGYLRDSSPA HHHHHCCEECCCCCC	9.48	27050516
433	Phosphorylation	DSLDEARSSGSEGTP CCHHHHHHCCCCCCC	46.21	23927012
434	Phosphorylation	SLDEARSSGSEGTPA CHHHHHHCCCCCCCC	40.56	23927012
436	Phosphorylation	DEARSSGSEGTPADT HHHHHCCCCCCCCCC	34.50	23927012
439	Phosphorylation	RSSGSEGTPADTGDL HHCCCCCCCCCCCCC	15.97	23927012
443	Phosphorylation	SEGTPADTGDLSPGH CCCCCCCCCCCCCCC	34.40	26657352
447	Phosphorylation	PADTGDLSPGHGASA CCCCCCCCCCCCCCC	33.31	23401153
453	Phosphorylation	LSPGHGASAPSVSRE CCCCCCCCCCCCCHH	45.35	28450419
456	Phosphorylation	GHGASAPSVSREARQ CCCCCCCCCCHHHHH	32.23	28450419
458	Phosphorylation	GASAPSVSREARQTV CCCCCCCCHHHHHCC	28.83	28450419
474	Phosphorylation	PLTVRLHTQSVSECI CEEEEEECCCHHHHC	27.42	23312004
476	Phosphorylation	TVRLHTQSVSECITE EEEEECCCHHHHCCC	28.85	24719451
478	Phosphorylation	RLHTQSVSECITEDG EEECCCHHHHCCCCC	31.81	23532336
482	Phosphorylation	QSVSECITEDGRTVA CCHHHHCCCCCCEEE	39.42	23532336
522	Phosphorylation	QKEDGEPSWREAKVS CCCCCCCCCCEEEEE	34.17	26091039
540	Phosphorylation	SPTTSFLSISKLSPF CCCCEEEEHHHCCCH	23.86	24719451
558	Acetylation	FKLRFNRKKKGMYRK HHHHHCCCCCCHHHH	61.00	7684987
559	Acetylation	KLRFNRKKKGMYRKA HHHHCCCCCCHHHHH	51.85	7684995
565	Acetylation	KKKGMYRKAITEAAN CCCCHHHHHHHHHHH	27.01	7685203

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PWP2B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PWP2B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PWP2B_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PWP2B_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis.";
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III;
J. Proteome Res. 7:1346-1351(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-186, AND MASSSPECTROMETRY.
PubMed: 18220336

"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-250, AND MASSSPECTROMETRY.
PubMed: 18187866

"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-291, AND MASSSPECTROMETRY.
PubMed: 17525332