P4HTM_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: P4HTM_HUMAN
• UniProt AC: Q9NXG6
• Protein Name: Transmembrane prolyl 4-hydroxylase
• Gene Name: P4HTM
• Organism: Homo sapiens (Human).
• Sequence Length: 502
• Subcellular Localization: Endoplasmic reticulum membrane ; Single-pass type II membrane protein .
• Protein Description: Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex..
• Protein Sequence: MAAAAVTGQRPETAAAEEASRPQWAPPDHCQAQAAAGLGDGEDAPVRPLCKPRGICSRAYFLVLMVFVHLYLGNVLALLLFVHYSNGDESSDPGPQHRAQGPGPEPTLGPLTRLEGIKVGHERKVQLVTDRDHFIRTLSLKPLLFEIPGFLTDEECRLIIHLAQMKGLQRSQILPTEEYEEAMSTMQVSQLDLFRLLDQNRDGHLQLREVLAQTRLGNGWWMTPESIQEMYAAIKADPDGDGVLSLQEFSNMDLRDFHKYMRSHKAESSELVRNSHHTWLYQGEGAHHIMRAIRQRVLRLTRLSPEIVELSEPLQVVRYGEGGHYHAHVDSGPVYPETICSHTKLVANESVPFETSCRYMTVLFYLNNVTGGGETVFPVADNRTYDEMSLIQDDVDLRDTRRHCDKGNLRVKPQQGTAVFWYNYLPDGQGWVGDVDDYSLHGGCLVTRGTKWIANNWINVDPSRARQALFQQEMARLAREGGTDSQPEWALDRAYRDARVEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
57	Phosphorylation	CKPRGICSRAYFLVL CCCCCHHHHHHHHHH	20.30	26270265
118	Ubiquitination	LTRLEGIKVGHERKV CEECCCCEECCCCEE	53.68	29967540
141 (in isoform 3)	Ubiquitination	-	30.18	21906983
141 (in isoform 2)	Ubiquitination	-	30.18	21906983
141	Ubiquitination	FIRTLSLKPLLFEIP HHHHHCCHHHHCCCC	30.18	21906983
141 (in isoform 1)	Ubiquitination	-	30.18	21906983
176	O-linked_Glycosylation	QRSQILPTEEYEEAM CHHHCCCHHHHHHHH	37.69	OGP
265 (in isoform 3)	Ubiquitination	-	55.91	21906983
265 (in isoform 2)	Ubiquitination	-	55.91	21906983
265	Ubiquitination	HKYMRSHKAESSELV HHHHHHCCCCCCHHH	55.91	2190698
265 (in isoform 1)	Ubiquitination	-	55.91	21906983
268	Phosphorylation	MRSHKAESSELVRNS HHHCCCCCCHHHHCC	33.69	-
269	Phosphorylation	RSHKAESSELVRNSH HHCCCCCCHHHHCCC	26.84	-
278	Phosphorylation	LVRNSHHTWLYQGEG HHHCCCCCEEECCCH	16.25	-
348	N-linked_Glycosylation	SHTKLVANESVPFET CCCEEECCCCCCHHC	34.30	UniProtKB CARBOHYD
361	Phosphorylation	ETSCRYMTVLFYLNN HCCCCCEEEEEEEEC	12.72	-
368	N-linked_Glycosylation	TVLFYLNNVTGGGET EEEEEEECCCCCCCE	30.08	UniProtKB CARBOHYD
382	N-linked_Glycosylation	TVFPVADNRTYDEMS EEEEECCCCCCCCHH	28.58	UniProtKB CARBOHYD
388	Sulfoxidation	DNRTYDEMSLIQDDV CCCCCCCHHHHCCCC	3.45	30846556

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of P4HTM_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of P4HTM_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of P4HTM_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of P4HTM_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00126: Vitamin C