R3HD2_HUMAN - dbPTM
R3HD2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID R3HD2_HUMAN
UniProt AC Q9Y2K5
Protein Name R3H domain-containing protein 2
Gene Name R3HDM2
Organism Homo sapiens (Human).
Sequence Length 976
Subcellular Localization Nucleus .
Protein Description
Protein Sequence MSNSNTTQETLEIMKESEKKLVEESVNKNKFISKTPSKEEIEKECEDTSLRQETQRRTSNHGHARKRAKSNSKLKLVRSLAVCEESSTPFADGPLETQDIIQLHISCPSDKEEEKSTKDVSEKEDKDKNKEKIPRKMLSRDSSQEYTDSTGIDLHEFLVNTLKKNPRDRMMLLKLEQEILEFINDNNNQFKKFPQMTSYHRMLLHRVAAYFGMDHNVDQTGKAVIINKTSNTRIPEQRFSEHIKDEKNTEFQQRFILKRDDASMDRDDNQTGQNGYLNDIRLSKEAFSSSSHKRRQIFRGNREGLSRTSSSRQSSTDSELKSLEPRPWSSTDSDGSVRSMRPPVTKASSFSGISILTRGDSIGSSKGGSAGRISRPGMALGAPEVCNQVTSSQSVRGLLPCTAQQQQQQQQQQLPALPPTPQQQPPLNNHMISQADDLSNPFGQMSLSRQGSTEAADPSAALFQTPLISQHPQQTSFIMASTGQPLPTSNYSTSSHAPPTQQVLPPQGYMQPPQQIQVSYYPPGQYPNSNQQYRPLSHPVAYSPQRGQQLPQPSQQPGLQPMMPNQQQAAYQGMIGVQQPQNQGLLSSQRSSMGGQMQGLVVQYTPLPSYQVPVGSDSQNVVQPPFQQPMLVPVSQSVQGGLPAAGVPVYYSMIPPAQQNGTSPSVGFLQPPGSEQYQMPQSPSPCSPPQMPQQYSGVSPSGPGVVVMQLNVPNGPQPPQNPSMVQWSHCKYYSMDQRGQKPGDLYSPDSSPQANTQMSSSPVTSPTQSPAPSPVTSLSSVCTGLSPLPVLTQFPRPGGPAQGDGRYSLLGQPLQYNLSICPPLLHGQSTYTVHQGQSGLKHGNRGKRQALKSASTDLGTADVVLGRVLEVTDLPEGITRTEADKLFTQLAMSGAKIQWLKDAQGLPGGGGGDNSGTAENGRHSDLAALYTIVAVFPSPLAAQNASLRLNNSVSRFKLRMAKKNYDLRILERASSQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSNSNTTQE
------CCCCCCHHH		49.30-
4Phosphorylation----MSNSNTTQETL
----CCCCCCHHHHH		28.39-
33PhosphorylationVNKNKFISKTPSKEE
HHHCCCCCCCCCHHH		33.3421712546
35PhosphorylationKNKFISKTPSKEEIE
HCCCCCCCCCHHHHH		26.4630278072
37PhosphorylationKFISKTPSKEEIEKE
CCCCCCCCHHHHHHH		58.9123401153
48PhosphorylationIEKECEDTSLRQETQ
HHHHHHCCCHHHHHH		13.8428060719
49PhosphorylationEKECEDTSLRQETQR
HHHHHCCCHHHHHHH		33.6028060719
86PhosphorylationSLAVCEESSTPFADG
HHHHCCCCCCCCCCC		19.7426074081
87PhosphorylationLAVCEESSTPFADGP
HHHCCCCCCCCCCCC		43.3026074081
88PhosphorylationAVCEESSTPFADGPL
HHCCCCCCCCCCCCC		31.5326074081
97PhosphorylationFADGPLETQDIIQLH
CCCCCCCCCCEEEEE		38.9426074081
106PhosphorylationDIIQLHISCPSDKEE
CEEEEEEECCCCHHH		14.8226074081
109PhosphorylationQLHISCPSDKEEEKS
EEEEECCCCHHHHHC		66.6926074081
139PhosphorylationKIPRKMLSRDSSQEY
HCCHHHHCCCCCCCC		30.4622617229
142PhosphorylationRKMLSRDSSQEYTDS
HHHHCCCCCCCCCCC		32.5830278072
143PhosphorylationKMLSRDSSQEYTDST
HHHCCCCCCCCCCCC		31.1830278072
146PhosphorylationSRDSSQEYTDSTGID
CCCCCCCCCCCCCCC		14.2822115753
147PhosphorylationRDSSQEYTDSTGIDL
CCCCCCCCCCCCCCH		23.7922115753
149PhosphorylationSSQEYTDSTGIDLHE
CCCCCCCCCCCCHHH		22.2723403867
150PhosphorylationSQEYTDSTGIDLHEF
CCCCCCCCCCCHHHH		40.7523403867
161PhosphorylationLHEFLVNTLKKNPRD
HHHHHHHHHHCCHHH		32.2623090842
163UbiquitinationEFLVNTLKKNPRDRM
HHHHHHHHCCHHHHH		48.76-
191UbiquitinationNDNNNQFKKFPQMTS
CCCCCCHHCCHHCHH		43.68-
210PhosphorylationLLHRVAAYFGMDHNV
HHHHHHHHHCCCCCC		7.3024719451
220PhosphorylationMDHNVDQTGKAVIIN
CCCCCCCCCCEEEEE		35.8724719451
229PhosphorylationKAVIINKTSNTRIPE
CEEEEECCCCCCCCC		23.7924719451
263PhosphorylationILKRDDASMDRDDNQ
EEECCCCCCCCCCCC		28.3628348404
271PhosphorylationMDRDDNQTGQNGYLN
CCCCCCCCCCCCCCC		47.1727251275
308PhosphorylationNREGLSRTSSSRQSS
CCCCCCCCCCCCCCC		29.5930177828
309PhosphorylationREGLSRTSSSRQSST
CCCCCCCCCCCCCCC		25.8028102081
310PhosphorylationEGLSRTSSSRQSSTD
CCCCCCCCCCCCCCH		29.0028102081
311PhosphorylationGLSRTSSSRQSSTDS
CCCCCCCCCCCCCHH		33.8228102081
314PhosphorylationRTSSSRQSSTDSELK
CCCCCCCCCCHHHHH		33.8123312004
315PhosphorylationTSSSRQSSTDSELKS
CCCCCCCCCHHHHHH		28.0926657352
316PhosphorylationSSSRQSSTDSELKSL
CCCCCCCCHHHHHHC		49.1123312004
318PhosphorylationSRQSSTDSELKSLEP
CCCCCCHHHHHHCCC		44.9423312004
322PhosphorylationSTDSELKSLEPRPWS
CCHHHHHHCCCCCCC		51.0628985074
329PhosphorylationSLEPRPWSSTDSDGS
HCCCCCCCCCCCCCC		26.4929507054
330PhosphorylationLEPRPWSSTDSDGSV
CCCCCCCCCCCCCCC		32.1528450419
331PhosphorylationEPRPWSSTDSDGSVR
CCCCCCCCCCCCCCC		33.7228450419
333PhosphorylationRPWSSTDSDGSVRSM
CCCCCCCCCCCCCCC		43.9128450419
336PhosphorylationSSTDSDGSVRSMRPP
CCCCCCCCCCCCCCC		21.2428450419
345O-linked_GlycosylationRSMRPPVTKASSFSG
CCCCCCCCCCCCCCC		27.0230059200
348PhosphorylationRPPVTKASSFSGISI
CCCCCCCCCCCCEEE		33.2129255136
349PhosphorylationPPVTKASSFSGISIL
CCCCCCCCCCCEEEE		28.4329255136
351PhosphorylationVTKASSFSGISILTR
CCCCCCCCCEEEEEC		36.8529255136
354PhosphorylationASSFSGISILTRGDS
CCCCCCEEEEECCCC		18.3123927012
357PhosphorylationFSGISILTRGDSIGS
CCCEEEEECCCCCCC		30.8225159151
361PhosphorylationSILTRGDSIGSSKGG
EEEECCCCCCCCCCC		31.5025159151
364PhosphorylationTRGDSIGSSKGGSAG
ECCCCCCCCCCCCCC		27.4922199227
365PhosphorylationRGDSIGSSKGGSAGR
CCCCCCCCCCCCCCC		30.0622199227
374PhosphorylationGGSAGRISRPGMALG
CCCCCCCCCCCCCCC		30.9426356563
390PhosphorylationPEVCNQVTSSQSVRG
HHHHHCCCCCCHHHH		16.9426356563
391PhosphorylationEVCNQVTSSQSVRGL
HHHHCCCCCCHHHHH		27.7626356563
392PhosphorylationVCNQVTSSQSVRGLL
HHHCCCCCCHHHHHH		19.6726356563
394PhosphorylationNQVTSSQSVRGLLPC
HCCCCCCHHHHHHHC		18.7426356563
446PhosphorylationSNPFGQMSLSRQGST
CCCCCCCHHCCCCCC		18.4626074081
448PhosphorylationPFGQMSLSRQGSTEA
CCCCCHHCCCCCCCC		18.4326074081
452PhosphorylationMSLSRQGSTEAADPS
CHHCCCCCCCCCCCC		18.0926074081
453PhosphorylationSLSRQGSTEAADPSA
HHCCCCCCCCCCCCH		36.1526074081
542PhosphorylationPLSHPVAYSPQRGQQ
CCCCCCCCCCCCCCC		22.5527732954
543PhosphorylationLSHPVAYSPQRGQQL
CCCCCCCCCCCCCCC		12.5727732954
734PhosphorylationWSHCKYYSMDQRGQK
CCCCEEEECCCCCCC		16.8825849741
852MethylationRGKRQALKSASTDLG
HHHHHHHHHCCCCCC		47.17115976013
852UbiquitinationRGKRQALKSASTDLG
HHHHHHHHHCCCCCC		47.17-
853PhosphorylationGKRQALKSASTDLGT
HHHHHHHHCCCCCCH		28.4423401153
855PhosphorylationRQALKSASTDLGTAD
HHHHHHCCCCCCHHH		29.5529255136
856PhosphorylationQALKSASTDLGTADV
HHHHHCCCCCCHHHH		34.6529255136
860PhosphorylationSASTDLGTADVVLGR
HCCCCCCHHHHHHCE		27.2923927012
872PhosphorylationLGRVLEVTDLPEGIT
HCEEEEEECCCCCCC		23.5727251789
879PhosphorylationTDLPEGITRTEADKL
ECCCCCCCHHHHHHH		42.2527251789
885UbiquitinationITRTEADKLFTQLAM
CCHHHHHHHHHHHHH		53.18-
888PhosphorylationTEADKLFTQLAMSGA
HHHHHHHHHHHHCCC		32.8622673903
893PhosphorylationLFTQLAMSGAKIQWL
HHHHHHHCCCCEEEE		29.9622673903
896UbiquitinationQLAMSGAKIQWLKDA
HHHHCCCCEEEEHHC		38.67-
901UbiquitinationGAKIQWLKDAQGLPG
CCCEEEEHHCCCCCC		48.32-
924PhosphorylationTAENGRHSDLAALYT
CCCCCCHHHHHHHHH		32.72-
930PhosphorylationHSDLAALYTIVAVFP
HHHHHHHHHHHHHCC		6.95-
974PhosphorylationLRILERASSQ-----
HHHHHHHHCC-----		100.0023882029
975PhosphorylationRILERASSQ------
HHHHHHHCC------		0.0028985074
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of R3HD2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of R3HD2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of R3HD2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
F168A_HUMANFAM168Aphysical
25416956
KRA32_HUMANKRTAP3-2physical
25416956
CA094_HUMANC1orf94physical
25416956
KR108_HUMANKRTAP10-8physical
25416956
KR103_HUMANKRTAP10-3physical
25416956
NT2NL_HUMANNOTCH2NLphysical
25416956
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of R3HD2_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-853, AND MASSSPECTROMETRY.
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-348 AND SER-855, ANDMASS SPECTROMETRY.

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