dbPTM

ANS1A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ANS1A_HUMAN
UniProt AC	Q92625
Protein Name	Ankyrin repeat and SAM domain-containing protein 1A
Gene Name	ANKS1A
Organism	Homo sapiens (Human).
Sequence Length	1134
Subcellular Localization	Cytoplasm. Cell projection. Cytoplasmic before and after growth factor treatment.
Protein Description	Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity)..
Protein Sequence	MGKEQELLEAARTGHLPAVEKLLSGKRLSSGFGGGGGGGSGGGGGGSGGGGGGLGSSSHPLSSLLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMGSALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVRELPSQKSQQIAALIEDHMTGKRSTKEVDKTPPPQPPLISSMDSISQKSQGDVEKAVTELIIDFDANAEEEGPYEALYNAISCHSLDSMASGRSSDQDSTNKEAEAAGVKPAGVRPRERPPPPAKPPPDEEEEDHIDKKYFPLTASEVLSMRPRIHGSAAREEDEHPYELLLTAETKKVVLVDGKTKDHRRSSSSRSQDSAEGQDGQVPEQFSGLLHGSSPVCEVGQDPFQLLCTAGQSHPDGSPQQGACHKASMQLEETGVHAPGASQPSALDQSKRVGYLTGLPTTNSRSHPETLTHTASPHPGGAEEGDRSGARSRAPPTSKPKAELKLSRSLSKSDSDLLTCSPTEDATMGSRSESLSNCSIGKKRLEKSPSFASEWDEIEKIMSSIGEGIDFSQERQKISGLRTLEQSVGEWLESIGLQQYESKLLLNGFDDVHFLGSNVMEEQDLRDIGISDPQHRRKLLQAARSLPKVKALGYDGNSPPSVPSWLDSLGLQDYVHSFLSSGYSSIDTVKNLWELELVNVLKVQLLGHRKRIIASLADRPYEEPPQKPPRFSQLRCQDLLSQTSSPLSQNDSCTGRSADLLLPPGDTGRRRHDSLHDPAAPSRAERFRIQEEHREAKLTLRPPSLAAPYAPVQSWQHQPEKLIFESCGYEANYLGSMLIKDLRGTESTQDACAKMRKSTEHMKKIPTIILSITYKGVKFIDASNKNVIAEHEIRNISCAAQDPEDLCTFAYITKDLQTSHHYCHVFSTVDVNLTYEIILTLGQAFEVAYQLALQAQKSRATGASAAEMIETKSSKPVPKPRVGVRKSALEPPDMDQDAQSHASVSWVVDPKPDSKRSLSTN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MGKEQELLE ------CCHHHHHHH	54.21	12439753
3	Ubiquitination	-----MGKEQELLEA -----CCHHHHHHHH	68.99	-
21	Ubiquitination	GHLPAVEKLLSGKRL CCCHHHHHHHCCCCC	48.40	-
29	Phosphorylation	LLSGKRLSSGFGGGG HHCCCCCCCCCCCCC	32.23	101546335
30	Phosphorylation	LSGKRLSSGFGGGGG HCCCCCCCCCCCCCC	42.61	28674151
40	Phosphorylation	GGGGGGGSGGGGGGS CCCCCCCCCCCCCCC	37.22	28348404
181	Ubiquitination	DPTMRNNKFETPLDL CCCCCCCCCCCHHHH	48.39	-
215	Ubiquitination	LLSCNTKKHTPLHLA CCCCCCCCCCCCHHH	51.15	-
294	Ubiquitination	VRELPSQKSQQIAAL HHHCCCHHHHHHHHH	55.35	-
309	Ubiquitination	IEDHMTGKRSTKEVD HHHHHCCCCCCCCCC	33.73	-
318	Phosphorylation	STKEVDKTPPPQPPL CCCCCCCCCCCCCCC	36.24	23401153
327	Phosphorylation	PPQPPLISSMDSISQ CCCCCCCCCCHHHHH	27.56	30266825
328	Phosphorylation	PQPPLISSMDSISQK CCCCCCCCCHHHHHH	21.44	23927012
331	Phosphorylation	PLISSMDSISQKSQG CCCCCCHHHHHHCCC	18.59	23927012
333	Phosphorylation	ISSMDSISQKSQGDV CCCCHHHHHHCCCHH	35.19	23927012
336	Phosphorylation	MDSISQKSQGDVEKA CHHHHHHCCCHHHHH	31.58	28985074
372	Phosphorylation	YNAISCHSLDSMASG HHHHHCCCHHHHHCC	37.89	26074081
381	Phosphorylation	DSMASGRSSDQDSTN HHHHCCCCCCCCCCH	41.62	29116813
382	Phosphorylation	SMASGRSSDQDSTNK HHHCCCCCCCCCCHH	37.62	26657352
386	Phosphorylation	GRSSDQDSTNKEAEA CCCCCCCCCHHHHHH	28.39	23186163
387	Phosphorylation	RSSDQDSTNKEAEAA CCCCCCCCHHHHHHC	59.61	23186163
427	Phosphorylation	EDHIDKKYFPLTASE CCCCCCCCCCCCHHH	19.03	25106551
431	Phosphorylation	DKKYFPLTASEVLSM CCCCCCCCHHHHHHC	28.51	27251275
433	Phosphorylation	KYFPLTASEVLSMRP CCCCCCHHHHHHCCC	24.01	27251275
445	Phosphorylation	MRPRIHGSAAREEDE CCCCCCCCCCCCCCC	12.46	28796482
454	Phosphorylation	AREEDEHPYELLLTA CCCCCCCCCEEEEEE	23.42	17016520
455	Phosphorylation	REEDEHPYELLLTAE CCCCCCCCEEEEEEC	22.55	27273156
460	Phosphorylation	HPYELLLTAETKKVV CCCEEEEEECCCEEE	23.55	45561869
463	Phosphorylation	ELLLTAETKKVVLVD EEEEEECCCEEEEEC	33.43	28152594
464	Ubiquitination	LLLTAETKKVVLVDG EEEEECCCEEEEECC	34.77	-
479	Phosphorylation	KTKDHRRSSSSRSQD CCCCCCCCCCCCCCC	34.23	9847857
480	Phosphorylation	TKDHRRSSSSRSQDS CCCCCCCCCCCCCCC	30.44	7658007
481	Phosphorylation	KDHRRSSSSRSQDSA CCCCCCCCCCCCCCC	30.90	11703631
482	Phosphorylation	DHRRSSSSRSQDSAE CCCCCCCCCCCCCCC	37.59	11704021
500	Phosphorylation	GQVPEQFSGLLHGSS CCCCHHHHHHHCCCC	28.38	26074081
506	Phosphorylation	FSGLLHGSSPVCEVG HHHHHCCCCCCEECC	22.26	26074081
507	Phosphorylation	SGLLHGSSPVCEVGQ HHHHCCCCCCEECCC	26.41	26074081
522	Phosphorylation	DPFQLLCTAGQSHPD CHHHHHEECCCCCCC	33.52	26074081
526	Phosphorylation	LLCTAGQSHPDGSPQ HHEECCCCCCCCCCC	35.75	26074081
531	Phosphorylation	GQSHPDGSPQQGACH CCCCCCCCCCCCCCC	27.24	26074081
541	Phosphorylation	QGACHKASMQLEETG CCCCCHHHHHHHHHC	16.32	26074081
563	Phosphorylation	QPSALDQSKRVGYLT CCCHHCCCCCCCCCC	23.30	28555341
568	Phosphorylation	DQSKRVGYLTGLPTT CCCCCCCCCCCCCCC	9.76	23403867
574	Phosphorylation	GYLTGLPTTNSRSHP CCCCCCCCCCCCCCC	43.59	25850435
575	Phosphorylation	YLTGLPTTNSRSHPE CCCCCCCCCCCCCCC	29.29	25850435
577	Phosphorylation	TGLPTTNSRSHPETL CCCCCCCCCCCCCCC	32.82	25850435
579	Phosphorylation	LPTTNSRSHPETLTH CCCCCCCCCCCCCCC	43.12	25849741
583	Phosphorylation	NSRSHPETLTHTASP CCCCCCCCCCCCCCC	41.21	29255136
585	Phosphorylation	RSHPETLTHTASPHP CCCCCCCCCCCCCCC	25.30	29255136
587	Phosphorylation	HPETLTHTASPHPGG CCCCCCCCCCCCCCC	24.48	29255136
589	Phosphorylation	ETLTHTASPHPGGAE CCCCCCCCCCCCCCC	25.54	29255136
601	Phosphorylation	GAEEGDRSGARSRAP CCCCCCCCCCCCCCC	41.36	23403867
610	Phosphorylation	ARSRAPPTSKPKAEL CCCCCCCCCCCHHHH	48.61	21406692
611	Phosphorylation	RSRAPPTSKPKAELK CCCCCCCCCCHHHHH	53.38	21406692
620	Phosphorylation	PKAELKLSRSLSKSD CHHHHHHCHHCCCCH	20.45	23401153
622	Phosphorylation	AELKLSRSLSKSDSD HHHHHCHHCCCCHHH	33.35	22167270
624	Phosphorylation	LKLSRSLSKSDSDLL HHHCHHCCCCHHHCC	31.21	22167270
626	Phosphorylation	LSRSLSKSDSDLLTC HCHHCCCCHHHCCEE	38.68	29255136
628	Phosphorylation	RSLSKSDSDLLTCSP HHCCCCHHHCCEECC	36.93	29255136
632	Phosphorylation	KSDSDLLTCSPTEDA CCHHHCCEECCCCCC	20.45	30266825
633	Carbamidation	SDSDLLTCSPTEDAT CHHHCCEECCCCCCC	4.65	17322306
634	Phosphorylation	DSDLLTCSPTEDATM HHHCCEECCCCCCCC	29.62	30266825
636	Phosphorylation	DLLTCSPTEDATMGS HCCEECCCCCCCCCC	30.15	23927012
640	Phosphorylation	CSPTEDATMGSRSES ECCCCCCCCCCCCHH	34.09	25159151
643	Phosphorylation	TEDATMGSRSESLSN CCCCCCCCCCHHHCC	23.08	23927012
645	Phosphorylation	DATMGSRSESLSNCS CCCCCCCCHHHCCCC	32.98	30266825
647	Phosphorylation	TMGSRSESLSNCSIG CCCCCCHHHCCCCCC	38.04	19664994
649	Phosphorylation	GSRSESLSNCSIGKK CCCCHHHCCCCCCHH	45.10	30266825
651	Carbamidation	RSESLSNCSIGKKRL CCHHHCCCCCCHHHH	2.56	17322306
652	Phosphorylation	SESLSNCSIGKKRLE CHHHCCCCCCHHHHH	38.33	19664994
660	Ubiquitination	IGKKRLEKSPSFASE CCHHHHHCCCCHHHC	72.72	-
661	Phosphorylation	GKKRLEKSPSFASEW CHHHHHCCCCHHHCH	19.19	22167270
663	Phosphorylation	KRLEKSPSFASEWDE HHHHCCCCHHHCHHH	40.30	22167270
666	Phosphorylation	EKSPSFASEWDEIEK HCCCCHHHCHHHHHH	36.89	30266825
676	Phosphorylation	DEIEKIMSSIGEGID HHHHHHHHHHCCCCC	23.44	30266825
677	Phosphorylation	EIEKIMSSIGEGIDF HHHHHHHHHCCCCCH	19.75	19664994
685	Phosphorylation	IGEGIDFSQERQKIS HCCCCCHHHHHHHHC	27.64	21815630
692	Phosphorylation	SQERQKISGLRTLEQ HHHHHHHCCCHHHHH	38.52	50565645
696	Phosphorylation	QKISGLRTLEQSVGE HHHCCCHHHHHHHHH	39.42	28632149
744	Phosphorylation	DLRDIGISDPQHRRK HHHHHCCCCHHHHHH	37.72	28188228
751	Ubiquitination	SDPQHRRKLLQAARS CCHHHHHHHHHHHHC	54.21	-
767	Phosphorylation	PKVKALGYDGNSPPS CCCCCCCCCCCCCCC	22.87	25627689
771	Phosphorylation	ALGYDGNSPPSVPSW CCCCCCCCCCCCCHH	43.66	25159151
774	Phosphorylation	YDGNSPPSVPSWLDS CCCCCCCCCCHHHHH	50.47	25627689
828	Phosphorylation	HRKRIIASLADRPYE CHHHHHHHHCCCCCC	17.43	21945579
834	Phosphorylation	ASLADRPYEEPPQKP HHHCCCCCCCCCCCC	33.54	21945579
845	Phosphorylation	PQKPPRFSQLRCQDL CCCCCCHHHHHHHHH	29.59	30804277
854	Phosphorylation	LRCQDLLSQTSSPLS HHHHHHHHCCCCCCC	38.41	50565637
856	Phosphorylation	CQDLLSQTSSPLSQN HHHHHHCCCCCCCCC	28.00	29396449
857	Phosphorylation	QDLLSQTSSPLSQND HHHHHCCCCCCCCCC	23.48	24719451
858	Phosphorylation	DLLSQTSSPLSQNDS HHHHCCCCCCCCCCC	32.99	21815630
870	Phosphorylation	NDSCTGRSADLLLPP CCCCCCCCCCEECCC	27.72	25850435
880	Phosphorylation	LLLPPGDTGRRRHDS EECCCCCCCCCCCCC	38.20	29255136
887	Phosphorylation	TGRRRHDSLHDPAAP CCCCCCCCCCCCCCC	22.83	23401153
895	Phosphorylation	LHDPAAPSRAERFRI CCCCCCCCHHHHHCC	39.12	25850435
912	Phosphorylation	EHREAKLTLRPPSLA HHHHHCCCCCCCCCC	21.73	101546343
917	Phosphorylation	KLTLRPPSLAAPYAP CCCCCCCCCCCCCCC	33.07	29523821
922	Phosphorylation	PPSLAAPYAPVQSWQ CCCCCCCCCCCCCCC	20.86	75325
927	Phosphorylation	APYAPVQSWQHQPEK CCCCCCCCCCCCCCC	29.01	23312004
946	Phosphorylation	SCGYEANYLGSMLIK HCCCCHHHHHHHHHH	21.35	18452278
949	Phosphorylation	YEANYLGSMLIKDLR CCHHHHHHHHHHHHC	14.07	18452278
958	Phosphorylation	LIKDLRGTESTQDAC HHHHHCCCCCHHHHH	21.96	18452278
980	Phosphorylation	EHMKKIPTIILSITY HHHHCCCEEEEEEEE	24.91	26074081
984	Phosphorylation	KIPTIILSITYKGVK CCCEEEEEEEECCCE	11.50	26074081
986	Phosphorylation	PTIILSITYKGVKFI CEEEEEEEECCCEEE	18.79	26074081
987	Phosphorylation	TIILSITYKGVKFID EEEEEEEECCCEEEC	12.22	26074081
1074	Phosphorylation	QAQKSRATGASAAEM HHHHHHHCCCCHHHH	31.97	20873877
1077	Phosphorylation	KSRATGASAAEMIET HHHHCCCCHHHHHHC	29.38	20873877
1081	Sulfoxidation	TGASAAEMIETKSSK CCCCHHHHHHCCCCC	2.62	21406390
1084	Phosphorylation	SAAEMIETKSSKPVP CHHHHHHCCCCCCCC	25.87	20873877
1086	Phosphorylation	AEMIETKSSKPVPKP HHHHHCCCCCCCCCC	51.52	20873877
1087	Phosphorylation	EMIETKSSKPVPKPR HHHHCCCCCCCCCCC	42.40	20873877
1100	Phosphorylation	PRVGVRKSALEPPDM CCCCCCHHHCCCCCC	27.76	81018479
1118	Phosphorylation	AQSHASVSWVVDPKP HHHCCCEEEEECCCC	16.20	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ANS1A_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ANS1A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ANS1A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EPHA8_HUMAN	EPHA8	physical	20100865
P55G_HUMAN	PIK3R3	physical	25814554
RHG10_HUMAN	ARHGAP10	physical	25814554
DOK3_HUMAN	DOK3	physical	25814554
KLF15_HUMAN	KLF15	physical	25814554
NHLC2_HUMAN	NHLRC2	physical	25814554
MOD5_HUMAN	TRIT1	physical	25814554
RANB3_HUMAN	RANBP3	physical	25814554
RB_HUMAN	RB1	physical	25814554
SMRD1_HUMAN	SMARCD1	physical	25814554

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ANS1A_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Cloning of a novel phosphotyrosine binding domain containingmolecule, Odin, involved in signaling by receptor tyrosine kinases."; Pandey A., Blagoev B., Kratchmarova I., Fernandez M., Nielsen M.,Kristiansen T.Z., Ohara O., Podtelejnikov A.V., Roche S., Lodish H.F.,Mann M.; Oncogene 21:8029-8036(2002). Cited for: PROTEIN SEQUENCE OF 540-564, ACETYLATION AT GLY-2, MASS SPECTROMETRY,AND CHARACTERIZATION.	12439753 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-663 AND SER-677, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-647; SER-661 ANDSER-663, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-318; SER-622; SER-626;SER-647 AND SER-661, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-887, AND MASSSPECTROMETRY.	18220336 [Abstract]
"Phosphoproteome of resting human platelets."; Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.; J. Proteome Res. 7:526-534(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-663, AND MASSSPECTROMETRY.	18088087 [Abstract]
"Multiple reaction monitoring for robust quantitative proteomicanalysis of cellular signaling networks."; Wolf-Yadlin A., Hautaniemi S., Lauffenburger D.A., White F.M.; Proc. Natl. Acad. Sci. U.S.A. 104:5860-5865(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-455, AND MASSSPECTROMETRY.	17389395 [Abstract]