SAC2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SAC2_HUMAN
• UniProt AC: Q9Y2H2
• Protein Name: Phosphatidylinositide phosphatase SAC2 {ECO:0000305}
• Gene Name: INPP5F {ECO:0000312|HGNC:HGNC:17054}
• Organism: Homo sapiens (Human).
• Sequence Length: 1132
• Subcellular Localization: Membrane, clathrin-coated pit . Early endosome . Recycling endosome . Also found on macropinosomes.
• Protein Description: Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling. [PubMed: 25869669 Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms]
• Protein Sequence: MELFQAKDHYILQQGERALWCSRRDGGLQLRPATDLLLAWNPICLGLVEGVIGKIQLHSDLPWWLILIRQKALVGKLPGDHEVCKVTKIAVLSLSEMEPQDLELELCKKHHFGINKPEKIIPSPDDSKFLLKTFTHIKSNVSAPNKKKVKESKEKEKLERRLLEELLKMFMDSESFYYSLTYDLTNSVQRQSTGERDGRPLWQKVDDRFFWNKYMIQDLTEIGTPDVDFWIIPMIQGFVQIEELVVNYTESSDDEKSSPETPPQESTCVDDIHPRFLVALISRRSRHRAGMRYKRRGVDKNGNVANYVETEQLIHVHNHTLSFVQTRGSVPVFWSQVGYRYNPRPRLDRSEKETVAYFCAHFEEQLNIYKKQVIINLVDQAGREKIIGDAYLKQVLLFNNSHLTYVSFDFHEHCRGMKFENVQTLTDAIYDIILDMKWCWVDEAGVICKQEGIFRVNCMDCLDRTNVVQAAIARVVMEQQLKKLGVMPPEQPLPVKCNRIYQIMWANNGDSISRQYAGTAALKGDFTRTGERKLAGVMKDGVNSANRYYLNRFKDAYRQAVIDLMQGIPVTEDLYSIFTKEKEHEALHKENQRSHQELISQLLQSYMKLLLPDDEKFHGGWALIDCDPSLIDATHRDVDVLLLLSNSAYYVAYYDDEVDKVNQYQRLSLENLEKIEIGPEPTLFGKPKFSCMRLHYRYKEASGYFHTLRAVMRNPEEDGKDTLQCIAEMLQITKQAMGSDLPIIEKKLERKSSKPHEDIIGIRSQNQGSLAQGKNFLMSKFSSLNQKVKQTKSNVNIGNLRKLGNFTKPEMKVNFLKPNLKVNLWKSDSSLETMENTGVMDKVQAESDGDMSSDNDSYHSDEFLTNSKSDEDRQLANSLESVGPIDYVLPSCGIIASAPRLGSRSQSLSSTDSSVHAPSEITVAHGSGLGKGQESPLKKSPSAGDVHILTGFAKPMDIYCHRFVQDAQNKVTHLSETRSVSQQASQERNQMTNQVSNETQSESTEQTPSRPSQLDVSLSATGPQFLSVEPAHSVASQKTPTSASSMLELETGLHVTPSPSESSSSRAVSPFAKIRSSMVQVASITQAGLTHGINFAVSKVQKSPPEPEIINQVQQNELKKMFIQCQTRIIQI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
123	Phosphorylation	KPEKIIPSPDDSKFL CCHHHCCCCCCCHHH	30.47	30266825
127	Phosphorylation	IIPSPDDSKFLLKTF HCCCCCCCHHHHHHH	32.46	30266825
138	Acetylation	LKTFTHIKSNVSAPN HHHHHHHHHCCCCCC	28.51	19822409
192	Phosphorylation	TNSVQRQSTGERDGR CCHHHHCCCCCCCCC	40.34	30576142
193	Phosphorylation	NSVQRQSTGERDGRP CHHHHCCCCCCCCCC	34.42	30576142
257	Phosphorylation	ESSDDEKSSPETPPQ CCCCCCCCCCCCCCC	49.42	25002506
258	Phosphorylation	SSDDEKSSPETPPQE CCCCCCCCCCCCCCC	37.51	25002506
261	Phosphorylation	DEKSSPETPPQESTC CCCCCCCCCCCCCCC	43.59	28985074
266	Phosphorylation	PETPPQESTCVDDIH CCCCCCCCCCCCCCC	23.12	23312004
267	Phosphorylation	ETPPQESTCVDDIHP CCCCCCCCCCCCCCH	18.78	23312004
341	Phosphorylation	WSQVGYRYNPRPRLD HHHCCCCCCCCCCCC	22.49	22985185
369	Phosphorylation	FEEQLNIYKKQVIIN HHHHHHHHCHHHHHH	15.85	24260401
391	Phosphorylation	EKIIGDAYLKQVLLF HHHCCHHHHHEEEEE	21.12	21406692
430	Phosphorylation	QTLTDAIYDIILDMK HHHHHHHHHHHHCCC	11.65	22817900
544	Phosphorylation	VMKDGVNSANRYYLN HHHCCCHHHHHHHHH	25.23	25106551
575	Phosphorylation	IPVTEDLYSIFTKEK CCCCHHHHHHHCHHH	16.43	-
668	Phosphorylation	VNQYQRLSLENLEKI CHHHHCCCHHHHCCC	35.51	30266825
698	Phosphorylation	CMRLHYRYKEASGYF EEEEEEEHHHHHCCH	13.15	23186163
702	Phosphorylation	HYRYKEASGYFHTLR EEEHHHHHCCHHHHH	34.81	23186163
704	Phosphorylation	RYKEASGYFHTLRAV EHHHHHCCHHHHHHH	6.95	23186163
707	Phosphorylation	EASGYFHTLRAVMRN HHHCCHHHHHHHHHC	14.19	24043423
733	Phosphorylation	IAEMLQITKQAMGSD HHHHHHHHHHHHCCC	12.25	24114839
783	Phosphorylation	FLMSKFSSLNQKVKQ HHHHHHHHHHHHHHH	34.18	25002506
793	Phosphorylation	QKVKQTKSNVNIGNL HHHHHCCCCCCCCHH	49.77	25159151
827	Phosphorylation	LKVNLWKSDSSLETM EEEEEEECCCCCHHH	31.01	19664994
829	Phosphorylation	VNLWKSDSSLETMEN EEEEECCCCCHHHHH	43.86	23401153
830	Phosphorylation	NLWKSDSSLETMENT EEEECCCCCHHHHHC	34.90	29255136
833	Phosphorylation	KSDSSLETMENTGVM ECCCCCHHHHHCCCC	34.77	23927012
837	Phosphorylation	SLETMENTGVMDKVQ CCHHHHHCCCCCEEE	20.18	23403867
853	Phosphorylation	ESDGDMSSDNDSYHS CCCCCCCCCCCCCCC	33.52	30576142
857	Phosphorylation	DMSSDNDSYHSDEFL CCCCCCCCCCCCHHH	30.88	30576142
869	Phosphorylation	EFLTNSKSDEDRQLA HHHHCCCCHHHHHHH	46.16	29507054
878	Phosphorylation	EDRQLANSLESVGPI HHHHHHHHHHHCCCC	28.10	26657352
881	Phosphorylation	QLANSLESVGPIDYV HHHHHHHHCCCCCEE	37.35	22199227
887	Phosphorylation	ESVGPIDYVLPSCGI HHCCCCCEECCCCCE	12.47	27732954
905	Phosphorylation	APRLGSRSQSLSSTD CCCCCCCCCCCCCCC	26.31	22617229
907	Phosphorylation	RLGSRSQSLSSTDSS CCCCCCCCCCCCCCC	31.31	25159151
909	Phosphorylation	GSRSQSLSSTDSSVH CCCCCCCCCCCCCCC	36.12	21082442
910	Phosphorylation	SRSQSLSSTDSSVHA CCCCCCCCCCCCCCC	41.34	23898821
911	Phosphorylation	RSQSLSSTDSSVHAP CCCCCCCCCCCCCCC	36.20	23663014
913	Phosphorylation	QSLSSTDSSVHAPSE CCCCCCCCCCCCCCE	34.06	23663014
914	Phosphorylation	SLSSTDSSVHAPSEI CCCCCCCCCCCCCEE	22.26	23663014
919	Phosphorylation	DSSVHAPSEITVAHG CCCCCCCCEEEEECC	42.27	27732954
922	Phosphorylation	VHAPSEITVAHGSGL CCCCCEEEEECCCCC	13.95	27732954
927	Phosphorylation	EITVAHGSGLGKGQE EEEEECCCCCCCCCC	22.45	26074081
935	Phosphorylation	GLGKGQESPLKKSPS CCCCCCCCCCCCCCC	27.87	26055452
940	Phosphorylation	QESPLKKSPSAGDVH CCCCCCCCCCCCCCE	23.62	30266825
942	Phosphorylation	SPLKKSPSAGDVHIL CCCCCCCCCCCCEEE	52.56	29255136
950	Phosphorylation	AGDVHILTGFAKPMD CCCCEEEECCCCCCE	29.65	28464451
959	Phosphorylation	FAKPMDIYCHRFVQD CCCCCEEEHHHHHHH	4.30	25159151
985	Phosphorylation	RSVSQQASQERNQMT HCHHHHHHHHHHHHH	28.39	28348404
1012	Phosphorylation	EQTPSRPSQLDVSLS CCCCCCCHHCEEEEE	42.12	24719451
1036	Phosphorylation	EPAHSVASQKTPTSA CCCCCCCCCCCCCCH	30.01	24719451
1039	Phosphorylation	HSVASQKTPTSASSM CCCCCCCCCCCHHHH	24.94	25002506
1041	Phosphorylation	VASQKTPTSASSMLE CCCCCCCCCHHHHEE	42.00	25002506
1042	Phosphorylation	ASQKTPTSASSMLEL CCCCCCCCHHHHEEE	27.62	25002506
1044	Phosphorylation	QKTPTSASSMLELET CCCCCCHHHHEEEEC	18.95	25002506
1045	Phosphorylation	KTPTSASSMLELETG CCCCCHHHHEEEECC	27.40	25002506
1051	Phosphorylation	SSMLELETGLHVTPS HHHEEEECCCEECCC	58.63	25002506
1056	Phosphorylation	LETGLHVTPSPSESS EECCCEECCCCCCCC	13.80	25002506
1058	Phosphorylation	TGLHVTPSPSESSSS CCCEECCCCCCCCCC	31.52	25002506
1060	Phosphorylation	LHVTPSPSESSSSRA CEECCCCCCCCCCCC	55.22	25002506
1062	Phosphorylation	VTPSPSESSSSRAVS ECCCCCCCCCCCCCC	39.60	25002506
1063	Phosphorylation	TPSPSESSSSRAVSP CCCCCCCCCCCCCCC	28.42	25002506
1069	Phosphorylation	SSSSRAVSPFAKIRS CCCCCCCCCHHHHHH	17.20	23927012
1098	Phosphorylation	HGINFAVSKVQKSPP CCHHEHHHCCCCCCC	24.55	26074081
1102	Acetylation	FAVSKVQKSPPEPEI EHHHCCCCCCCCHHH	68.84	69663
1103	Phosphorylation	AVSKVQKSPPEPEII HHHCCCCCCCCHHHH	28.70	30266825
1103	O-linked_Glycosylation	AVSKVQKSPPEPEII HHHCCCCCCCCHHHH	28.70	29351928

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SAC2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SAC2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SAC2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SAC2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1069, AND MASSSPECTROMETRY.
PubMed: 18669648