SNX24_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SNX24_HUMAN
• UniProt AC: Q9Y343
• Protein Name: Sorting nexin-24
• Gene Name: SNX24
• Organism: Homo sapiens (Human).
• Sequence Length: 169
• Subcellular Localization: Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side.
• Protein Description: May be involved in several stages of intracellular trafficking..
• Protein Sequence: MEVYIPSFRYEESDLERGYTVFKIEVLMNGRKHFVEKRYSEFHALHKKLKKCIKTPEIPSKHVRNWVPKVLEQRRQGLETYLQAVILENEELPKLFLDFLNVRHLPSLPKAESCGSFDETESEESSKLSHQPVLLFLRDPYVLPAASDFPNVVIEGVLHGIFYPHLQPR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEVYIPSF -------CCEECCCC	7.68	22814378
13	Phosphorylation	PSFRYEESDLERGYT CCCCCCHHHHCCCEE	35.24	29759185
19	Phosphorylation	ESDLERGYTVFKIEV HHHHCCCEEEEEEEE	13.12	29759185
20	Phosphorylation	SDLERGYTVFKIEVL HHHCCCEEEEEEEEE	23.45	29759185
40	Phosphorylation	HFVEKRYSEFHALHK HHHHHHHHHHHHHHH	37.51	27251275
42	Ubiquitination	VEKRYSEFHALHKKL HHHHHHHHHHHHHHH	3.16	23000965
60	Phosphorylation	IKTPEIPSKHVRNWV HCCCCCCCHHHHHHH	40.84	24719451
69	Ubiquitination	HVRNWVPKVLEQRRQ HHHHHHHHHHHHHHH	50.24	23000965
102	Ubiquitination	LFLDFLNVRHLPSLP HHHHHHCCCCCCCCC	4.42	23000965
113	Phosphorylation	PSLPKAESCGSFDET CCCCCCHHCCCCCCC	28.74	23927012
116	Phosphorylation	PKAESCGSFDETESE CCCHHCCCCCCCCCH	33.57	30278072
120	Phosphorylation	SCGSFDETESEESSK HCCCCCCCCCHHHHC	46.81	23927012
122	Phosphorylation	GSFDETESEESSKLS CCCCCCCCHHHHCCC	54.83	23403867
125	Phosphorylation	DETESEESSKLSHQP CCCCCHHHHCCCCCC	28.81	23403867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SNX24_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SNX24_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SNX24_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
1433Z_HUMAN	YWHAZ	physical	21900206
SEPT2_HUMAN	SEPT2	physical	22863883
FLNC_HUMAN	FLNC	physical	26186194
KPTN_HUMAN	KPTN	physical	26186194
ITFG2_HUMAN	ITFG2	physical	26186194
UGPA_HUMAN	UGP2	physical	26186194
GDS1_HUMAN	RAP1GDS1	physical	26186194
KC1A_HUMAN	CSNK1A1	physical	28514442
GAPD1_HUMAN	GAPVD1	physical	28514442
LONF2_HUMAN	LONRF2	physical	28514442
SNX22_HUMAN	SNX22	physical	28514442
UGPA_HUMAN	UGP2	physical	28514442
PACS1_HUMAN	PACS1	physical	28514442
AF9_HUMAN	MLLT3	physical	28514442
FBP1L_HUMAN	FNBP1L	physical	28514442
PHOCN_HUMAN	MOB4	physical	28514442
HINT1_HUMAN	HINT1	physical	28514442
STRN_HUMAN	STRN	physical	28514442
1433G_HUMAN	YWHAG	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-116, AND MASSSPECTROMETRY.
PubMed: 19413330