5NT1A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: 5NT1A_HUMAN
• UniProt AC: Q9BXI3
• Protein Name: Cytosolic 5'-nucleotidase 1A
• Gene Name: NT5C1A
• Organism: Homo sapiens (Human).
• Sequence Length: 368
• Subcellular Localization: Cytoplasm.
• Protein Description: Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia..
• Protein Sequence: MEPGQPREPQEPREPGPGAETAAAPVWEEAKIFYDNLAPKKKPKSPKPQNAVTIAVSSRALFRMDEEQQIYTEQGVEEYVRYQLEHENEPFSPGPAFPFVKALEAVNRRLRELYPDSEDVFDIVLMTNNHAQVGVRLINSINHYDLFIERFCMTGGNSPICYLKAYHTNLYLSADAEKVREAIDEGIAAATIFSPSRDVVVSQSQLRVAFDGDAVLFSDESERIVKAHGLDRFFEHEKAHENKPLAQGPLKGFLEALGRLQKKFYSKGLRLECPIRTYLVTARSAASSGARALKTLRSWGLETDEALFLAGAPKGPLLEKIRPHIFFDDQMFHVAGAQEMGTVAAHVPYGVAQTPRRTAPAKQAPSAQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Acetylation	APVWEEAKIFYDNLA CCHHHHHHHHHHCCC	36.31	7678659
34	Phosphorylation	WEEAKIFYDNLAPKK HHHHHHHHHCCCCCC	13.85	25884760
45	Phosphorylation	APKKKPKSPKPQNAV CCCCCCCCCCCCCCE	46.84	24117733
53	Phosphorylation	PKPQNAVTIAVSSRA CCCCCCEEEEEECCH	10.78	24117733
57	Phosphorylation	NAVTIAVSSRALFRM CCEEEEEECCHHCCC	12.70	24117733
58	Phosphorylation	AVTIAVSSRALFRMD CEEEEEECCHHCCCC	18.25	24117733
79	Phosphorylation	TEQGVEEYVRYQLEH HHHCHHHHHHHHCCC	4.09	-
204	Phosphorylation	RDVVVSQSQLRVAFD CCEEEEHHHEEEEEC	24.55	26437602
265	Phosphorylation	GRLQKKFYSKGLRLE HHHHHHHHHCCCCCC	20.53	-
266	Phosphorylation	RLQKKFYSKGLRLEC HHHHHHHHCCCCCCC	24.31	24719451
314	Acetylation	LFLAGAPKGPLLEKI HHHCCCCCCCHHHHH	73.04	18530717

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of 5NT1A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of 5NT1A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of 5NT1A_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of 5NT1A_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.