NPL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NPL_HUMAN
• UniProt AC: Q9BXD5
• Protein Name: N-acetylneuraminate lyase
• Gene Name: NPL
• Organism: Homo sapiens (Human).
• Sequence Length: 320
• Subcellular Localization: Cytoplasm.
• Protein Description: Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded (By similarity)..
• Protein Sequence: MAFPKKKLQGLVAATITPMTENGEINFSVIGQYVDYLVKEQGVKNIFVNGTTGEGLSLSVSERRQVAEEWVTKGKDKLDQVIIHVGALSLKESQELAQHAAEIGADGIAVIAPFFLKPWTKDILINFLKEVAAAAPALPFYYYHIPALTGVKIRAEELLDGILDKIPTFQGLKFSDTDLLDFGQCVDQNRQQQFAFLFGVDEQLLSALVMGATGAVGSTYNYLGKKTNQMLEAFEQKDFSLALNYQFCIQRFINFVVKLGFGVSQTKAIMTLVSGIPMGPPRLPLQKASREFTDSAEAKLKSLDFLSFTDLKDGNLEAGS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10 (in isoform 2)	Phosphorylation	-	32.33	22985185
52	Phosphorylation	NIFVNGTTGEGLSLS EEEECCCCCCCCCEE	34.33	-
57	Phosphorylation	GTTGEGLSLSVSERR CCCCCCCCEEHHHHH	29.47	-
59	Phosphorylation	TGEGLSLSVSERRQV CCCCCCEEHHHHHHH	21.88	-
89	Phosphorylation	IIHVGALSLKESQEL EEEECCCCHHHHHHH	36.54	24719451
227	Phosphorylation	YNYLGKKTNQMLEAF HHHCCHHHHHHHHHH	33.88	28509920
287	Ubiquitination	PPRLPLQKASREFTD CCCCCCHHHCHHCCC	56.89	-
293	Phosphorylation	QKASREFTDSAEAKL HHHCHHCCCHHHHHH	25.04	22210691
295	Phosphorylation	ASREFTDSAEAKLKS HCHHCCCHHHHHHHC	25.58	22210691
299	Ubiquitination	FTDSAEAKLKSLDFL CCCHHHHHHHCCCCC	48.21	-
302	Phosphorylation	SAEAKLKSLDFLSFT HHHHHHHCCCCCCEE	43.54	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NPL_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NPL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NPL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
NPL_HUMAN	NPL	physical	25416956
PEG10_HUMAN	PEG10	physical	26186194
NADC_HUMAN	QPRT	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.