SPESP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPESP_HUMAN
• UniProt AC: Q6UW49
• Protein Name: Sperm equatorial segment protein 1 {ECO:0000312|HGNC:HGNC:15570}
• Gene Name: SPESP1 {ECO:0000312|HGNC:HGNC:15570}
• Organism: Homo sapiens (Human).
• Sequence Length: 350
• Subcellular Localization: Cytoplasmic vesicle, secretory vesicle, acrosome . Small proacrosomal granules (during the Golgi phase), enlarged acrosomal vesicles (during the cap phase), acrosome (during the elongating phase), equatorial segment of the acrosome (during the matura
• Protein Description: Involved in fertilization ability of sperm..
• Protein Sequence: MKPLVLLVALLLWPSSVPAYPSITVTPDEEQNLNHYIQVLENLVRSVPSGEPGREKKSNSPKHVYSIASKGSKFKELVTHGDASTENDVLTNPISEETTTFPTGGFTPEIGKKKHTESTPFWSIKPNNVSIVLHAEEPYIENEEPEPEPEPAAKQTEAPRMLPVVTESSTSPYVTSYKSPVTTLDKSTGIGISTESEDVPQLSGETAIEKPEEFGKHPESWNNDDILKKILDINSQVQQALLSDTSNPAYREDIEASKDHLKRSLALAAAAEHKLKTMYKSQLLPVGRTSNKIDDIETVINMLCNSRSKLYEYLDIKCVPPEMREKAATVFNTLKNMCRSRRVTALLKVY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
65	Phosphorylation	SNSPKHVYSIASKGS CCCCCHHHEHHHCCC	8.28	-
128	N-linked_Glycosylation	FWSIKPNNVSIVLHA CEECCCCCEEEEEEE	37.12	UniProtKB CARBOHYD
168	Phosphorylation	MLPVVTESSTSPYVT EECEEECCCCCCCCC	29.56	26434552
171	Phosphorylation	VVTESSTSPYVTSYK EEECCCCCCCCCCCC	19.04	26434552
179	Phosphorylation	PYVTSYKSPVTTLDK CCCCCCCCCCEEECC	19.17	-
235	Phosphorylation	KKILDINSQVQQALL HHHHCCCHHHHHHHH	31.87	18491316
243	Phosphorylation	QVQQALLSDTSNPAY HHHHHHHCCCCCHHH	39.43	18491316
298	Phosphorylation	NKIDDIETVINMLCN CCHHHHHHHHHHHHC	27.33	30576142
306	Phosphorylation	VINMLCNSRSKLYEY HHHHHHCCCHHHHHH	36.61	20873877
333	Phosphorylation	KAATVFNTLKNMCRS HHHHHHHHHHHHHHH	27.87	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPESP_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPESP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPESP_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SPESP_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.