HYAL4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HYAL4_HUMAN
• UniProt AC: Q2M3T9
• Protein Name: Hyaluronidase-4
• Gene Name: HYAL4
• Organism: Homo sapiens (Human).
• Sequence Length: 481
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Description: Endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments. Has also chondroitin sulfate hydrolase activity, The best substrate being the galactosaminidic linkage in the sequence of a trisulfated tetrasaccharide..
• Protein Sequence: MKVLSEGQLKLCVVQPVHLTSWLLIFFILKSISCLKPARLPIYQRKPFIAAWNAPTDQCLIKYNLRLNLKMFPVIGSPLAKARGQNVTIFYVNRLGYYPWYTSQGVPINGGLPQNISLQVHLEKADQDINYYIPAEDFSGLAVIDWEYWRPQWARNWNSKDVYRQKSRKLISDMGKNVSATDIEYLAKVTFEESAKAFMKETIKLGIKSRPKGLWGYYLYPDCHNYNVYAPNYSGSCPEDEVLRNNELSWLWNSSAALYPSIGVWKSLGDSENILRFSKFRVHESMRISTMTSHDYALPVFVYTRLGYRDEPLFFLSKQDLVSTIGESAALGAAGIVIWGDMNLTASKANCTKVKQFVSSDLGSYIANVTRAAEVCSLHLCRNNGRCIRKMWNAPSYLHLNPASYHIEASEDGEFTVKGKASDTDLAVMADTFSCHCYQGYEGADCREIKTADGCSGVSPSPGSLMTLCLLLLASYRSIQL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Phosphorylation	LIFFILKSISCLKPA HHHHHHHHHHCCCCC	19.11	26074081
33	Phosphorylation	FFILKSISCLKPARL HHHHHHHHCCCCCCC	22.08	26074081
43	Phosphorylation	KPARLPIYQRKPFIA CCCCCCCCCCCCEEE	10.58	26074081
86	N-linked_Glycosylation	LAKARGQNVTIFYVN HHHHCCCCEEEEEEC	35.41	UniProtKB CARBOHYD
88	Phosphorylation	KARGQNVTIFYVNRL HHCCCCEEEEEECCC	16.96	24719451
115	N-linked_Glycosylation	INGGLPQNISLQVHL CCCCCCCCEEEEEEH	24.71	UniProtKB CARBOHYD
177	N-linked_Glycosylation	LISDMGKNVSATDIE HHHHCCCCCCHHHHH	27.52	19139490
267	Phosphorylation	PSIGVWKSLGDSENI CCCCHHHHCCCCHHH	23.13	27732954
271	Phosphorylation	VWKSLGDSENILRFS HHHHCCCCHHHCHHH	30.64	27732954
296	Phosphorylation	STMTSHDYALPVFVY EECCCCCCCEEEEEE	12.47	-
323	Phosphorylation	LSKQDLVSTIGESAA EEHHHHHHHHHHHHH	22.92	26434552
343	N-linked_Glycosylation	IVIWGDMNLTASKAN EEEECCCCCCCCCCC	38.69	UniProtKB CARBOHYD
345	Phosphorylation	IWGDMNLTASKANCT EECCCCCCCCCCCCC	24.71	26434552
347	Phosphorylation	GDMNLTASKANCTKV CCCCCCCCCCCCCHH	27.37	26434552
416	Phosphorylation	ASEDGEFTVKGKASD ECCCCCEEEEEEECC	19.60	22468782
422	Phosphorylation	FTVKGKASDTDLAVM EEEEEEECCCCEEEE	44.52	22468782
424	Phosphorylation	VKGKASDTDLAVMAD EEEEECCCCEEEEEE	30.34	22468782

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HYAL4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HYAL4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HYAL4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
G3PT_HUMAN	GAPDHS	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.