DKK2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DKK2_HUMAN
• UniProt AC: Q9UBU2
• Protein Name: Dickkopf-related protein 2
• Gene Name: DKK2
• Organism: Homo sapiens (Human).
• Sequence Length: 259
• Subcellular Localization: Secreted.
• Protein Description: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity)..
• Protein Sequence: MAALMRSKDSSCCLLLLAAVLMVESSQIGSSRAKLNSIKSSLGGETPGQAANRSAGMYQGLAFGGSKKGKNLGQAYPCSSDKECEVGRYCHSPHQGSSACMVCRRKKKRCHRDGMCCPSTRCNNGICIPVTESILTPHIPALDGTRHRDRNHGHYSNHDLGWQNLGRPHTKMSHIKGHEGDPCLRSSDCIEGFCCARHFWTKICKPVLHQGEVCTKQRKKGSHGLEIFQRCDCAKGLSCKVWKDATYSSKARLHVCQKI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
52	N-linked_Glycosylation	ETPGQAANRSAGMYQ CCCCHHHHHHCCCCC	41.26	UniProtKB CARBOHYD
58	Phosphorylation	ANRSAGMYQGLAFGG HHHHCCCCCHHHCCC	9.86	-
89	Phosphorylation	KECEVGRYCHSPHQG CCCEECCCCCCCCCC	6.65	-
92	Phosphorylation	EVGRYCHSPHQGSSA EECCCCCCCCCCCCC	22.10	-
97	Phosphorylation	CHSPHQGSSACMVCR CCCCCCCCCCHHHCC	14.27	-
98	Phosphorylation	HSPHQGSSACMVCRR CCCCCCCCCHHHCCC	32.10	-
155	Phosphorylation	RDRNHGHYSNHDLGW CCCCCCCCCCCCCCC	18.76	-
156	Phosphorylation	DRNHGHYSNHDLGWQ CCCCCCCCCCCCCCC	23.24	-
173	Phosphorylation	GRPHTKMSHIKGHEG CCCCCHHHHCCCCCC	24.50	28060719
222	Phosphorylation	TKQRKKGSHGLEIFQ CCCCCCCCCHHHHHH	24.22	26091039
250	Acetylation	KDATYSSKARLHVCQ CCCCCCCCHHEEEEC	31.42	30588189

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DKK2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DKK2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DKK2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of DKK2_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.