ADA28_HUMAN - dbPTM
ADA28_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ADA28_HUMAN
UniProt AC Q9UKQ2
Protein Name Disintegrin and metalloproteinase domain-containing protein 28
Gene Name ADAM28
Organism Homo sapiens (Human).
Sequence Length 775
Subcellular Localization Isoform 1: Cell membrane
Single-pass type I membrane protein.
Isoform 2: Secreted.
Protein Description May play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L. May be involved in sperm maturation..
Protein Sequence MLQGLLPVSLLLSVAVSAIKELPGVKKYEVVYPIRLHPLHKREAKEPEQQEQFETELKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKVSDASISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDSTCGMDGVLWAHDLQQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKRHDIAQLITATELAGTTVGLAFMSTMCSPYSVGVVQDHSDNLLRVAGTMAHEMGHNFGMFHDDYSCKCPSTICVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPICGNQLVEMGEDCDCGTSEECTNICCDAKTCKIKATFQCALGECCEKCQFKKAGMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWGPGTEVADKSCYNRNEGGSKYGYCRRVDDTLIPCKANDTMCGKLFCQGGSDNLPWKGRIVTFLTCKTFDPEDTSQEIGMVANGTKCGDNKVCINAECVDIEKAYKSTNCSSKCKGHAVCDHELQCQCEEGWIPPDCDDSSVVFHFSIVVGVLFPMAVIFVVVAMVIRHQSSREKQKKDQRPLSTTGTRPHKQKRKPQMVKAVQPQEMSQMKPHVYDLPVEGNEPPASFHKDTNALPPTVFKDNPVSTPKDSNPKA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
28PhosphorylationELPGVKKYEVVYPIR
CCCCCCEEEEEEEEE		14.2921210654
138PhosphorylationFSQGDQRYFIEPLSP
CCCCCEEEEEEECCC		11.8629083192
144PhosphorylationRYFIEPLSPIHRDGQ
EEEEEECCCCCCCCC		32.3029083192
237PhosphorylationRVFEMANYVNMLYKK
HHHHHHHHHHHHHHH		5.447475107
268N-linked_GlycosylationDKIKITPNASFTLEN
CCCCCCCCCCEEECC		39.30UniProtKB CARBOHYD
270PhosphorylationIKITPNASFTLENFS
CCCCCCCCEEECCHH		25.9626853621
275N-linked_GlycosylationNASFTLENFSKWRGS
CCCEEECCHHHHCCC		49.99UniProtKB CARBOHYD
282PhosphorylationNFSKWRGSVLSRRKR
CHHHHCCCHHHHHCH		16.0046159073
285PhosphorylationKWRGSVLSRRKRHDI
HHCCCHHHHHCHHCH		28.0828634120
557N-linked_GlycosylationTLIPCKANDTMCGKL
CEEECCCCCCCCCEE		30.68UniProtKB CARBOHYD
602N-linked_GlycosylationQEIGMVANGTKCGDN
HHEEEEECCCCCCCC		47.45UniProtKB CARBOHYD
628N-linked_GlycosylationEKAYKSTNCSSKCKG
HHHHHHCCCCHHCCC		30.66UniProtKB CARBOHYD
752PhosphorylationPASFHKDTNALPPTV
CCCCCCCCCCCCCCC		27.4829759185
758PhosphorylationDTNALPPTVFKDNPV
CCCCCCCCCCCCCCC		36.3129759185
766PhosphorylationVFKDNPVSTPKDSNP
CCCCCCCCCCCCCCC		40.0029759185
767PhosphorylationFKDNPVSTPKDSNPK
CCCCCCCCCCCCCCC		34.2929759185
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ADA28_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ADA28_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ADA28_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ADA28_HUMAN !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ADA28_HUMAN

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Related Literatures of Post-Translational Modification

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