IRX1_HUMAN - dbPTM
IRX1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID IRX1_HUMAN
UniProt AC P78414
Protein Name Iroquois-class homeodomain protein IRX-1
Gene Name IRX1
Organism Homo sapiens (Human).
Sequence Length 480
Subcellular Localization Nucleus .
Protein Description
Protein Sequence MSFPQLGYPQYLSAAGPGAYGGERPGVLAAAAAAAAAASSGRPGAAELGGGAGAAAVTSVLGMYAAAGPYAGAPNYSAFLPYAADLSLFSQMGSQYELKDNPGVHPATFAAHTAPAYYPYGQFQYGDPGRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKVTWGARSKDQEDGALFGSDTEGDPEKAEDDEEIDLESIDIDKIDEHDGDQSNEDDEDKAEAPHAPAAPSALARDQGSPLAAADVLKPQDSPLGLAKEAPEPGSTRLLSPGAAAGGLQGAPHGKPKIWSLAETATSPDGAPKASPPPPAGHPGAHGPSAGAPLQHPAFLPSHGLYTCHIGKFSNWTNSAFLAQGSLLNMRSFLGVGAPHAAPHGPHLPAPPPPQPPVAIAPGALNGDKASVRSSPTLPERDLVPRPDSPAQQLKSPFQPVRDNSLAPQEGTPRILAALPSA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSFPQLGYP
------CCCCCCCCC		45.7128842319
8PhosphorylationMSFPQLGYPQYLSAA
CCCCCCCCCHHHCCC		8.8528842319
208PhosphorylationEDGALFGSDTEGDPE
CCCCCCCCCCCCCHH		33.7428348404
210PhosphorylationGALFGSDTEGDPEKA
CCCCCCCCCCCHHHC		43.4927251275
241PhosphorylationDEHDGDQSNEDDEDK
CCCCCCCCCCCHHHH		47.1028348404
267PhosphorylationALARDQGSPLAAADV
HHHHCCCCCCCHHHH		15.8828450419
280PhosphorylationDVLKPQDSPLGLAKE
HHCCCCCCCCCCCCC		19.4422617229
298PhosphorylationPGSTRLLSPGAAAGG
CCCEEEECCCHHHCC		26.3628348404
322PhosphorylationKIWSLAETATSPDGA
CEEHHCCCCCCCCCC		29.6327251275
324PhosphorylationWSLAETATSPDGAPK
EHHCCCCCCCCCCCC		48.4927251275
325PhosphorylationSLAETATSPDGAPKA
HHCCCCCCCCCCCCC		20.6627251275
333PhosphorylationPDGAPKASPPPPAGH
CCCCCCCCCCCCCCC		44.0328348404
347PhosphorylationHPGAHGPSAGAPLQH
CCCCCCCCCCCCCCC		43.8828348404
432PhosphorylationGDKASVRSSPTLPER
CCCCCCCCCCCCCHH		38.2128857561
433PhosphorylationDKASVRSSPTLPERD
CCCCCCCCCCCCHHH		16.0228857561
435PhosphorylationASVRSSPTLPERDLV
CCCCCCCCCCHHHCC		57.8232142685
447PhosphorylationDLVPRPDSPAQQLKS
HCCCCCCCHHHHCCC		25.4728857561
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of IRX1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of IRX1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of IRX1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of IRX1_HUMAN !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of IRX1_HUMAN

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Related Literatures of Post-Translational Modification

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