ZN839_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZN839_HUMAN
• UniProt AC: A8K0R7
• Protein Name: Zinc finger protein 839
• Gene Name: ZNF839
• Organism: Homo sapiens (Human).
• Sequence Length: 811
• Protein Sequence: MLLPTTIQPQTARKSQLPRGNSCLVGLHIASPQLLRVQPLVRTEPQSCFLSDLCQPPAQGFVQRPLPALQVVPAKRVPAPKAPDEQGSMLTPLSASDPLAVTSLSSSSAHPFISNLHTRHTEKLKKSLKVKTRSGRVSRPPKYKAKDYKFIKTEDLADGHLSDSDDYSELCVEEDEDQRERHALFDLSSCSLRPKSFKCQTCEKSYIGKGGLARHFKLNPGHGQLDPEMVLSEKASGSTLRGCTEERTLSLTSLGLSMPADPCEGGARSCLVTESARGGLQNGQSVDVEETLPSEPENGALLRSERYQGPRRRACSETLAESRTAVLQQRRAAQLPGGPAAAGEQRASPSKARLKEFLQQCDREDLVELALPQLAQVVTVYEFLLMKVEKDHLAKPFFPAIYKEFEELHKMVKKMCQDYLSSSGLCSQETLEINNDKVAESLGITEFLRKKEIHPDNLGPKHLSRDMDGEQLEGASSEKREREAAEEGLASVKRPRREALSNDTTESLAANSRGREKPRPLHALAAGFSPPVNVTVSPRSEESHTTTVSGGNGSVFQAGPQLQALANLEARRGSIGAALSSRDVSGLPVYAQSGEPRRLTQAQVAAFPGENALEHSSDQDTWDSLRSPGFCSPLSSGGGAESLPPGGPGHAEAGHLGKVCDFHLNHQQPSPTSVLPTEVAAPPLEKILSVDSVAVDCAYRTVPKPGPQPGPHGSLLTEGCLRSLSGDLNRFPCGMEVHSGQRELESVVAVGEAMAFEISNGSHELLSQGQKQIFIQTSDGLILSPPGTIVSQEEDIVTVTDAEGRACGWAR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MLLPTTIQPQTA ---CCCCCCCCCCCC	36.18	24043423
6	Phosphorylation	--MLLPTTIQPQTAR --CCCCCCCCCCCCC	18.71	24043423
11	Phosphorylation	PTTIQPQTARKSQLP CCCCCCCCCCHHCCC	34.80	24043423
12 (in isoform 5)	Phosphorylation	-	16.20	30206219
27 (in isoform 5)	Phosphorylation	-	1.74	30206219
29 (in isoform 5)	Phosphorylation	-	4.96	30206219
31	Phosphorylation	LVGLHIASPQLLRVQ EEEEEECCCCCEEEE	16.75	21815630
80	Methylation	PAKRVPAPKAPDEQG ECCCCCCCCCCCCCC	27.54	-
108	Phosphorylation	VTSLSSSSAHPFISN EEECCCCCCCHHHHH	32.32	30576142
114	Phosphorylation	SSAHPFISNLHTRHT CCCCHHHHHCHHHCH	33.45	30576142
162	Phosphorylation	DLADGHLSDSDDYSE HCCCCCCCCCCCHHH	29.42	28348404
164	Phosphorylation	ADGHLSDSDDYSELC CCCCCCCCCCHHHHH	29.07	28348404
217	Ubiquitination	GGLARHFKLNPGHGQ CCHHHCCCCCCCCCC	41.03	29967540
250	Phosphorylation	CTEERTLSLTSLGLS CCCCCEEEEEECCCC	29.05	22210691
252	Phosphorylation	EERTLSLTSLGLSMP CCCEEEEEECCCCCC	20.66	24425749
257	Phosphorylation	SLTSLGLSMPADPCE EEEECCCCCCCCCCC	22.41	22210691
273	Phosphorylation	GARSCLVTESARGGL CCCEEEEEHHHCCCC	15.98	22210691
275	Phosphorylation	RSCLVTESARGGLQN CEEEEEHHHCCCCCC	17.56	25106551
278	Phosphorylation	LVTESARGGLQNGQS EEEHHHCCCCCCCCC	40.66	27251275
285	Phosphorylation	GGLQNGQSVDVEETL CCCCCCCCCCHHHCC	22.98	28348404
291	Phosphorylation	QSVDVEETLPSEPEN CCCCHHHCCCCCCCC	30.39	28348404
316	Phosphorylation	GPRRRACSETLAESR CCCHHHHHHHHHHHH	32.41	29255136
318	Phosphorylation	RRRACSETLAESRTA CHHHHHHHHHHHHHH	18.25	29255136
322	Phosphorylation	CSETLAESRTAVLQQ HHHHHHHHHHHHHHH	29.35	27251275
333	Ubiquitination	VLQQRRAAQLPGGPA HHHHHHHHCCCCCCC	15.05	29967540
348	Phosphorylation	AAGEQRASPSKARLK CCCCCCCCCCHHHHH	31.71	30576142
350	Phosphorylation	GEQRASPSKARLKEF CCCCCCCCHHHHHHH	36.13	22199227
378	Phosphorylation	LPQLAQVVTVYEFLL HHHHHHHHHHHHHHH	1.67	15302935
391	Phosphorylation	LLMKVEKDHLAKPFF HHHHHCHHHCCCCHH	28.64	27251275
432	Phosphorylation	LCSQETLEINNDKVA CCCHHHEEECCHHHH	51.60	27251275
450	Sumoylation	GITEFLRKKEIHPDN CHHHHHHCCCCCCCC	57.83	-
451	Ubiquitination	ITEFLRKKEIHPDNL HHHHHHCCCCCCCCC	56.31	29967540
451	Sumoylation	ITEFLRKKEIHPDNL HHHHHHCCCCCCCCC	56.31	-
461	Ubiquitination	HPDNLGPKHLSRDMD CCCCCCCCCCCCCCC	56.21	29967540
464	Phosphorylation	NLGPKHLSRDMDGEQ CCCCCCCCCCCCHHH	26.42	22210691
476	Phosphorylation	GEQLEGASSEKRERE HHHCCCCCHHHHHHH	50.30	22210691
477	Phosphorylation	EQLEGASSEKREREA HHCCCCCHHHHHHHH	46.75	22210691
535	Phosphorylation	FSPPVNVTVSPRSEE CCCCEEEEECCCCCC	15.29	27251275
537	Phosphorylation	PPVNVTVSPRSEESH CCEEEEECCCCCCCC	12.77	24719451
567	Ubiquitination	PQLQALANLEARRGS HHHHHHHCHHHHCCC	38.98	29967540
574	Phosphorylation	NLEARRGSIGAALSS CHHHHCCCHHHHHHC	18.94	28450419
577	Ubiquitination	ARRGSIGAALSSRDV HHCCCHHHHHHCCCC	11.98	29967540
653	Phosphorylation	GGPGHAEAGHLGKVC CCCCCCCCCCHHHEE	16.10	24719451
670	Phosphorylation	HLNHQQPSPTSVLPT ECCCCCCCCCCCCCC	36.15	28464451
672	Phosphorylation	NHQQPSPTSVLPTEV CCCCCCCCCCCCCCC	35.49	27080861
673	Phosphorylation	HQQPSPTSVLPTEVA CCCCCCCCCCCCCCC	25.66	28464451
677	Phosphorylation	SPTSVLPTEVAAPPL CCCCCCCCCCCCCCH	38.64	27080861
689	Phosphorylation	PPLEKILSVDSVAVD CCHHHHCCCCCEEEE	27.61	28348404
690	Phosphorylation	PLEKILSVDSVAVDC CHHHHCCCCCEEEEE	5.96	24719451
786	Phosphorylation	DGLILSPPGTIVSQE CCEEECCCCEEEECC	49.54	27251275
789	Phosphorylation	ILSPPGTIVSQEEDI EECCCCEEEECCCCC	3.30	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZN839_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZN839_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZN839_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.