NPAS3_HUMAN - dbPTM
NPAS3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NPAS3_HUMAN
UniProt AC Q8IXF0
Protein Name Neuronal PAS domain-containing protein 3
Gene Name NPAS3
Organism Homo sapiens (Human).
Sequence Length 933
Subcellular Localization Nucleus .
Protein Description May play a broad role in neurogenesis. May control regulatory pathways relevant to schizophrenia and to psychotic illness (By similarity)..
Protein Sequence MAPTKPSFQQDPSRRERITAQHPLPNQSECRKIYRYDGIYCESTYQNLQALRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQGDPPWNLRMEGPPPNTSVKVIGAQRRRSPSALAIEVFEAHLGSHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKLPPGRGLLSQGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTKRGVHIKSSGYKVIHITGRLRLRVSLSHGRTVPSQIMGLVVVAHALPPPTINEVRIDCHMFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLLNKGQCVTKYYRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDIAQLPHLPEKTSESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENSEDPEPDRKKSGNACDNDMNCNDDGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAMQIKVERYVESESDLRLQNCESLTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSASRRRLSSASSPGGLDAGLVEPPRLLSSPNSASVLKIKTEISEPINFDNDSSIWNYPPNREISRNESPYSMTKPPSSEHFPSPQGGGGGGGGGGGLHVAIPDSVLTPPGADGAAARKTQFGASATAALAPVASDPLSPPLSASPRDKHPGNGGGGGGGGGGAGGGGPSASNSLLYTGDLEALQRLQAGNVVLPLVHRVTGTLAATSTAAQRVYTTGTIRYAPAEVTLAMQSNLLPNAHAVNFVDVNSPGFGLDPKTPMEMLYHHVHRLNMSGPFGGAVSAASLTQMPAGNVFTTAEGLFSTLPFPVYSNGIHAAQTLERKED
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MAPTKPSFQQD
----CCCCCCCCCCC		46.1524719451
7Phosphorylation-MAPTKPSFQQDPSR
-CCCCCCCCCCCCCH		36.9224719451
13PhosphorylationPSFQQDPSRRERITA
CCCCCCCCHHHHHCC		52.8624719451
152PhosphorylationVFEAHLGSHILQSLD
HHHHHHHHHHHHHCC		17.45-
157PhosphorylationLGSHILQSLDGFVFA
HHHHHHHHCCCEEEE		25.61-
262PhosphorylationTDNTLERSFFIRMKS
CCCCHHHHEEEEECC		18.3523898821
269PhosphorylationSFFIRMKSTLTKRGV
HEEEEECCCCHHCCE		21.2123898821
270PhosphorylationFFIRMKSTLTKRGVH
EEEEECCCCHHCCEE		32.6923898821
272PhosphorylationIRMKSTLTKRGVHIK
EEECCCCHHCCEEEE		20.8423898821
438PhosphorylationYLLSNPEYKDTPMDI
EHHCCCCCCCCCCCH		18.5422817900
456PhosphorylationPHLPEKTSESSETSD
CCCCCCCCCCCCCCC		46.69-
466PhosphorylationSETSDSESDSKDTSG
CCCCCCCCCCCCCCC		51.65-
503PhosphorylationPEPDRKKSGNACDND
CCCCCCCCCCCCCCC		40.0730576142
519PhosphorylationNCNDDGHSSSNPDSR
CCCCCCCCCCCCCCC		40.7830576142
520PhosphorylationCNDDGHSSSNPDSRD
CCCCCCCCCCCCCCC		28.5830576142
521PhosphorylationNDDGHSSSNPDSRDS
CCCCCCCCCCCCCCC		56.2330576142
525PhosphorylationHSSSNPDSRDSDDSF
CCCCCCCCCCCCCCC		38.9630576142
563PhosphorylationKVERYVESESDLRLQ
EEEEEECCCCHHCCC		32.1528348404
565PhosphorylationERYVESESDLRLQNC
EEEECCCCHHCCCCC		51.7528348404
638PhosphorylationVEPPRLLSSPNSASV
CCCCCCCCCCCCCCE		48.6328348404
639PhosphorylationEPPRLLSSPNSASVL
CCCCCCCCCCCCCEE		28.2424719451
642PhosphorylationRLLSSPNSASVLKIK
CCCCCCCCCCEEEEE		25.8827251275
681PhosphorylationSRNESPYSMTKPPSS
CCCCCCCCCCCCCCC		24.30-
752PhosphorylationDPLSPPLSASPRDKH
CCCCCCCCCCCCCCC		32.2627251275
754PhosphorylationLSPPLSASPRDKHPG
CCCCCCCCCCCCCCC		19.6627251275
812O-linked_GlycosylationLVHRVTGTLAATSTA
EEEHHHCHHHHCCCC		12.1228657654
816PhosphorylationVTGTLAATSTAAQRV
HHCHHHHCCCCCHHE		22.4729759185
817O-linked_GlycosylationTGTLAATSTAAQRVY
HCHHHHCCCCCHHEE		16.0128657654
818O-linked_GlycosylationGTLAATSTAAQRVYT
CHHHHCCCCCHHEEE		22.9728657654
818PhosphorylationGTLAATSTAAQRVYT
CHHHHCCCCCHHEEE		22.9729759185
867PhosphorylationGFGLDPKTPMEMLYH
CCCCCCCCHHHHHHH		33.0023663014
873PhosphorylationKTPMEMLYHHVHRLN
CCHHHHHHHHHHHCC		6.6423663014
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NPAS3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NPAS3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NPAS3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ARNT2_HUMANARNT2physical
24722188
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NPAS3_HUMAN

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Related Literatures of Post-Translational Modification

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