GTR12_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GTR12_HUMAN
• UniProt AC: Q8TD20
• Protein Name: Solute carrier family 2, facilitated glucose transporter member 12
• Gene Name: SLC2A12
• Organism: Homo sapiens (Human).
• Sequence Length: 617
• Subcellular Localization: Endomembrane system; Multi-pass membrane protein. Cytoplasm, perinuclear region . Localizes primarily perinuclear region in the absence of insulin.
• Protein Description: Facilitative glucose transporter..
• Protein Sequence: MVPVENTEGPSLLNQKGTAVETEGSGSRHPPWARGCGMFTFLSSVTAAVSGLLVGYELGIISGALLQIKTLLALSCHEQEMVVSSLVIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYTVLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILSAYISNYAFANVFHGWKYMFGLVIPLGVLQAIAMYFLPPSPRFLVMKGQEGAASKVLGRLRALSDTTEELTVIKSSLKDEYQYSFWDLFRSKDNMRTRIMIGLTLVFFVQITGQPNILFYASTVLKSVGFQSNEAASLASTGVGVVKVISTIPATLLVDHVGSKTFLCIGSSVMAASLVTMGIVNLNIHMNFTHICRSHNSINQSLDESVIYGPGNLSTNNNTLRDHFKGISSHSRSSLMPLRNDVDKRGETTSASLLNAGLSHTEYQIVTDPGDVPAFLKWLSLASLLVYVAAFSIGLGPMPWLVLSEIFPGGIRGRAMALTSSMNWGINLLISLTFLTVTDLIGLPWVCFIYTIMSLASLLFVVMFIPETKGCSLEQISMELAKVNYVKNNICFMSHHQEELVPKQPQKRKPQEQLLECNKLCGRGQSRQLSPET

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	SLLNQKGTAVETEGS CCCCCCCCEEEECCC	34.27	27251275
22	Phosphorylation	QKGTAVETEGSGSRH CCCCEEEECCCCCCC	38.76	-
25	Phosphorylation	TAVETEGSGSRHPPW CEEEECCCCCCCCCC	27.62	-
108	Phosphorylation	IDRYGRRTAIILSSC HHCCCHHHHHHHHHH	22.35	-
113	Phosphorylation	RRTAIILSSCLLGLG HHHHHHHHHHHHCHH	14.48	-
114	Phosphorylation	RTAIILSSCLLGLGS HHHHHHHHHHHCHHH	12.82	-
198	Phosphorylation	NVFHGWKYMFGLVIP HHHCHHHHHHCCHHH	7.38	-
215	Phosphorylation	VLQAIAMYFLPPSPR HHHHHHHHHCCCCCC	7.92	-
220	Phosphorylation	AMYFLPPSPRFLVMK HHHHCCCCCCEEEEC	27.11	23312004
235	Ubiquitination	GQEGAASKVLGRLRA CCCHHHHHHHHHHHH	36.43	23000965
244	Phosphorylation	LGRLRALSDTTEELT HHHHHHHCCCCHHHH	31.74	30266825
246	Phosphorylation	RLRALSDTTEELTVI HHHHHCCCCHHHHHH	32.50	29514088
247	Phosphorylation	LRALSDTTEELTVIK HHHHCCCCHHHHHHH	32.24	29514088
254	Ubiquitination	TEELTVIKSSLKDEY CHHHHHHHHHCCCCH	29.65	21890473
258	Ubiquitination	TVIKSSLKDEYQYSF HHHHHHCCCCHHHCH	50.92	23000965
263	Phosphorylation	SLKDEYQYSFWDLFR HCCCCHHHCHHHHHH	12.63	22210691
264	Phosphorylation	LKDEYQYSFWDLFRS CCCCHHHCHHHHHHC	12.34	22210691
284	Phosphorylation	TRIMIGLTLVFFVQI HHHHCCCEEEEEECC	18.70	24400094
292	Phosphorylation	LVFFVQITGQPNILF EEEEECCCCCCCEEE	16.81	24400094
300	Phosphorylation	GQPNILFYASTVLKS CCCCEEEEEEEHHHH	9.01	24400094
303	Phosphorylation	NILFYASTVLKSVGF CEEEEEEEHHHHCCC	22.99	24400094
312	Phosphorylation	LKSVGFQSNEAASLA HHHCCCCCHHHHHHH	34.08	-
371	N-linked_Glycosylation	VNLNIHMNFTHICRS CEEEEECCHHHHHCC	25.22	UniProtKB CARBOHYD
383	N-linked_Glycosylation	CRSHNSINQSLDESV HCCCCHHCCCCCCCC	25.80	UniProtKB CARBOHYD
396	N-linked_Glycosylation	SVIYGPGNLSTNNNT CCCCCCCCCCCCCCH	33.67	UniProtKB CARBOHYD
401	N-linked_Glycosylation	PGNLSTNNNTLRDHF CCCCCCCCCHHHHHH	42.84	UniProtKB CARBOHYD
432	O-linked_Glycosylation	DVDKRGETTSASLLN CCHHCCCCCCHHHHH	28.95	55834983
433	O-linked_Glycosylation	VDKRGETTSASLLNA CHHCCCCCCHHHHHC	20.28	55834987
434	O-linked_Glycosylation	DKRGETTSASLLNAG HHCCCCCCHHHHHCC	24.23	55834993
445	O-linked_Glycosylation	LNAGLSHTEYQIVTD HHCCCCCCEEEEECC	32.77	55831495

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GTR12_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GTR12_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GTR12_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TM242_HUMAN	TMEM242	physical	28514442
TAM41_HUMAN	TAMM41	physical	28514442
MTFR2_HUMAN	MTFR2	physical	28514442
ORML2_HUMAN	ORMDL2	physical	28514442
SCMC3_HUMAN	SLC25A23	physical	28514442
MFRN2_HUMAN	SLC25A28	physical	28514442
S2551_HUMAN	SLC25A51	physical	28514442
TSPO_HUMAN	TSPO	physical	28514442
PIGW_HUMAN	PIGW	physical	28514442
S19A2_HUMAN	SLC19A2	physical	28514442
AB17B_HUMAN	ABHD17B	physical	28514442
MET15_HUMAN	METTL15	physical	28514442
PEX16_HUMAN	PEX16	physical	28514442
SELT_HUMAN	SELT	physical	28514442
SPPL3_HUMAN	SPPL3	physical	28514442
HACD2_HUMAN	PTPLB	physical	28514442
ABCB8_HUMAN	ABCB8	physical	28514442
SFXN5_HUMAN	SFXN5	physical	28514442
SCMC1_HUMAN	SLC25A24	physical	28514442
TMM11_HUMAN	TMEM11	physical	28514442
ABD18_HUMAN	C4orf29	physical	28514442
EFR3A_HUMAN	EFR3A	physical	28514442
ATLA2_HUMAN	ATL2	physical	28514442
ALG8_HUMAN	ALG8	physical	28514442
ATLA3_HUMAN	ATL3	physical	28514442
NSUN3_HUMAN	NSUN3	physical	28514442
ASML_HUMAN	ASMTL	physical	28514442
COQ8B_HUMAN	ADCK4	physical	28514442
TIM14_HUMAN	DNAJC19	physical	28514442
COT2_HUMAN	NR2F2	physical	28514442
SERC1_HUMAN	SERINC1	physical	28514442
TTK_HUMAN	TTK	physical	28514442
MTX1_HUMAN	MTX1	physical	28514442
CY24A_HUMAN	CYBA	physical	28514442
DYN3_HUMAN	DNM3	physical	28514442
KIRR1_HUMAN	KIRREL	physical	28514442
GLPK_HUMAN	GK	physical	28514442
SMAP2_HUMAN	SMAP2	physical	28514442
PDXD1_HUMAN	PDXDC1	physical	28514442
RER1_HUMAN	RER1	physical	28514442
GHITM_HUMAN	GHITM	physical	28514442
TARB1_HUMAN	TARBP1	physical	28514442
HXD13_HUMAN	HOXD13	physical	28514442
ACD10_HUMAN	ACAD10	physical	28514442
GNL1_HUMAN	GNL1	physical	28514442
FITM2_HUMAN	FITM2	physical	28514442
CHSTB_HUMAN	CHST11	physical	28514442
SPG7_HUMAN	SPG7	physical	28514442
EBP_HUMAN	EBP	physical	28514442
DOLK_HUMAN	DOLK	physical	28514442
BCS1_HUMAN	BCS1L	physical	28514442
PTPM1_HUMAN	PTPMT1	physical	28514442
ORML3_HUMAN	ORMDL3	physical	28514442
WDFY3_HUMAN	WDFY3	physical	28514442
TM2D3_HUMAN	TM2D3	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.