NEIL3_HUMAN - dbPTM
NEIL3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NEIL3_HUMAN
UniProt AC Q8TAT5
Protein Name Endonuclease 8-like 3
Gene Name NEIL3
Organism Homo sapiens (Human).
Sequence Length 605
Subcellular Localization Nucleus .
Protein Description DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity. In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues. Seems to be an important facilitator of cell proliferation in certain populations, for example neural stem/progenitor cells and tumor cells, suggesting a role in replication-associated DNA repair..
Protein Sequence MVEGPGCTLNGEKIRARVLPGQAVTGVRGSALRSLQGRALRLAASTVVVSPQAAALNNDSSQNVLSLFNGYVYSGVETLGKELFMYFGPKALRIHFGMKGFIMINPLEYKYKNGASPVLEVQLTKDLICFFDSSVELRNSMESQQRIRMMKELDVCSPEFSFLRAESEVKKQKGRMLGDVLMDQNVLPGVGNIIKNEALFDSGLHPAVKVCQLTDEQIHHLMKMIRDFSILFYRCRKAGLALSKHYKVYKRPNCGQCHCRITVCRFGDNNRMTYFCPHCQKENPQHVDICKLPTRNTIISWTSSRVDHVMDSVARKSEEHWTCVVCTLINKPSSKACDACLTSRPIDSVLKSEENSTVFSHLMKYPCNTFGKPHTEVKINRKTAFGTTTLVLTDFSNKSSTLERKTKQNQILDEEFQNSPPASVCLNDIQHPSKKTTNDITQPSSKVNISPTISSESKLFSPAHKKPKTAQYSSPELKSCNPGYSNSELQINMTDGPRTLNPDSPRCSKHNRLCILRVVGKDGENKGRQFYACPLPREAQCGFFEWADLSFPFCNHGKRSTMKTVLKIGPNNGKNFFVCPLGKEKQCNFFQWAENGPGIKIIPGC
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
13UbiquitinationGCTLNGEKIRARVLP
CCEECCCEEEEEECC		38.60-
90UbiquitinationLFMYFGPKALRIHFG
HHHHHCCCEEEEEEE		61.50-
110UbiquitinationMINPLEYKYKNGASP
EECCCEEEECCCCCC		40.1321906983
112UbiquitinationNPLEYKYKNGASPVL
CCCEEEECCCCCCEE		44.7622817900
140O-linked_GlycosylationSSVELRNSMESQQRI
CCHHHHHCHHHHHHH		19.9330379171
151UbiquitinationQQRIRMMKELDVCSP
HHHHHHHHHHCCCCC		45.8721963094
167PhosphorylationFSFLRAESEVKKQKG
HHHHHCHHHHHHHHC		46.8628060719
195UbiquitinationPGVGNIIKNEALFDS
CCCCHHHCCHHHHCC		44.9629967540
195SumoylationPGVGNIIKNEALFDS
CCCCHHHCCHHHHCC		44.96-
209UbiquitinationSGLHPAVKVCQLTDE
CCCCCCHHHHHCCHH		39.1229967540
223UbiquitinationEQIHHLMKMIRDFSI
HHHHHHHHHHHHHHH		37.22-
229PhosphorylationMKMIRDFSILFYRCR
HHHHHHHHHHHHHHH		23.7527251275
233PhosphorylationRDFSILFYRCRKAGL
HHHHHHHHHHHHHHH		12.8327251275
237UbiquitinationILFYRCRKAGLALSK
HHHHHHHHHHHHHHH		50.8933845483
244AcetylationKAGLALSKHYKVYKR
HHHHHHHHCCEEECC		52.3770943
244UbiquitinationKAGLALSKHYKVYKR
HHHHHHHHCCEEECC		52.3733845483
246PhosphorylationGLALSKHYKVYKRPN
HHHHHHCCEEECCCC		13.09-
247UbiquitinationLALSKHYKVYKRPNC
HHHHHCCEEECCCCC		38.52-
247AcetylationLALSKHYKVYKRPNC
HHHHHCCEEECCCCC		38.5270947
250AcetylationSKHYKVYKRPNCGQC
HHCCEEECCCCCCCC		65.4570951
274PhosphorylationGDNNRMTYFCPHCQK
CCCCCEEEECCCCCC		8.2129496907
281UbiquitinationYFCPHCQKENPQHVD
EECCCCCCCCCCCCE		65.92-
291UbiquitinationPQHVDICKLPTRNTI
CCCCEECCCCCCCCE		58.8133845483
316UbiquitinationVMDSVARKSEEHWTC
HHHHHHHCCHHCEEE		53.10-
331UbiquitinationVVCTLINKPSSKACD
EEEEEECCCCCCCCC		39.00-
351UbiquitinationRPIDSVLKSEENSTV
CCCHHHHCCCCCCCH		54.3821963094
364UbiquitinationTVFSHLMKYPCNTFG
CHHHHHHCCCCCCCC		53.0229967540
372UbiquitinationYPCNTFGKPHTEVKI
CCCCCCCCCCCEEEE		29.4533845483
378UbiquitinationGKPHTEVKINRKTAF
CCCCCEEEECCCCCC		28.2129967540
382UbiquitinationTEVKINRKTAFGTTT
CEEEECCCCCCCCEE		39.45-
383PhosphorylationEVKINRKTAFGTTTL
EEEECCCCCCCCEEE		24.79-
396PhosphorylationTLVLTDFSNKSSTLE
EEEEECCCCCCHHHC		46.2723403867
398UbiquitinationVLTDFSNKSSTLERK
EEECCCCCCHHHCHH		44.5821906983
399PhosphorylationLTDFSNKSSTLERKT
EECCCCCCHHHCHHH		32.5723403867
401PhosphorylationDFSNKSSTLERKTKQ
CCCCCCHHHCHHHHH		39.4623403867
407UbiquitinationSTLERKTKQNQILDE
HHHCHHHHHHHHCCH		50.7329967540
419PhosphorylationLDEEFQNSPPASVCL
CCHHHHCCCCHHHHH		22.8327080861
434UbiquitinationNDIQHPSKKTTNDIT
CCCCCCCCCCCCCCC		59.60-
435UbiquitinationDIQHPSKKTTNDITQ
CCCCCCCCCCCCCCC		65.99-
444PhosphorylationTNDITQPSSKVNISP
CCCCCCCCCCCCCCC		32.73-
445PhosphorylationNDITQPSSKVNISPT
CCCCCCCCCCCCCCC		47.51-
446UbiquitinationDITQPSSKVNISPTI
CCCCCCCCCCCCCCC		43.5721890473
450PhosphorylationPSSKVNISPTISSES
CCCCCCCCCCCCCCC		15.7029255136
452PhosphorylationSKVNISPTISSESKL
CCCCCCCCCCCCCCC		27.0530576142
454PhosphorylationVNISPTISSESKLFS
CCCCCCCCCCCCCCC		30.4529396449
455PhosphorylationNISPTISSESKLFSP
CCCCCCCCCCCCCCC		41.8829396449
457PhosphorylationSPTISSESKLFSPAH
CCCCCCCCCCCCCCC		36.2829396449
458SumoylationPTISSESKLFSPAHK
CCCCCCCCCCCCCCC		49.88-
458SumoylationPTISSESKLFSPAHK
CCCCCCCCCCCCCCC		49.88-
458UbiquitinationPTISSESKLFSPAHK
CCCCCCCCCCCCCCC		49.8829967540
461PhosphorylationSSESKLFSPAHKKPK
CCCCCCCCCCCCCCC		31.4525003641
465UbiquitinationKLFSPAHKKPKTAQY
CCCCCCCCCCCCCCC		73.25-
466UbiquitinationLFSPAHKKPKTAQYS
CCCCCCCCCCCCCCC		41.71-
468UbiquitinationSPAHKKPKTAQYSSP
CCCCCCCCCCCCCCC		66.43-
474PhosphorylationPKTAQYSSPELKSCN
CCCCCCCCCCHHHCC		19.9124719451
504PhosphorylationPRTLNPDSPRCSKHN
CCCCCCCCCCCCCCC		18.5921815630
558UbiquitinationFPFCNHGKRSTMKTV
CCCCCCCCCCCCEEE		35.31-
560O-linked_GlycosylationFCNHGKRSTMKTVLK
CCCCCCCCCCEEEEE		36.0230379171
561O-linked_GlycosylationCNHGKRSTMKTVLKI
CCCCCCCCCEEEEEE		27.0730379171
563UbiquitinationHGKRSTMKTVLKIGP
CCCCCCCEEEEEECC		35.2522817900
564PhosphorylationGKRSTMKTVLKIGPN
CCCCCCEEEEEECCC		21.90-
567UbiquitinationSTMKTVLKIGPNNGK
CCCEEEEEECCCCCC		41.0822817900
574UbiquitinationKIGPNNGKNFFVCPL
EECCCCCCCEEEECC		53.3422505724
583UbiquitinationFFVCPLGKEKQCNFF
EEEECCCCCCCCCHH		70.2229967540
585UbiquitinationVCPLGKEKQCNFFQW
EECCCCCCCCCHHHH		64.7322505724
600UbiquitinationAENGPGIKIIPGC--
HHHCCCCEECCCC--		40.26-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NEIL3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NEIL3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NEIL3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ROCK1_HUMANROCK1physical
26496610
SFSWA_HUMANSFSWAPphysical
26496610
GTR1_HUMANSLC2A1physical
26496610
SMCA4_HUMANSMARCA4physical
26496610
BCL7C_HUMANBCL7Cphysical
26496610
CMC2_HUMANSLC25A13physical
26496610
SF3B2_HUMANSF3B2physical
26496610
NNTM_HUMANNNTphysical
26496610
BICRA_HUMANGLTSCR1physical
26496610
CARF_HUMANCDKN2AIPphysical
26496610
PR40A_HUMANPRPF40Aphysical
26496610
HMCES_HUMANHMCESphysical
26496610
ENY2_HUMANENY2physical
26496610
RBM25_HUMANRBM25physical
26496610
RSBNL_HUMANRSBN1Lphysical
26496610
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NEIL3_HUMAN

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Related Literatures of Post-Translational Modification

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