ACKR3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ACKR3_HUMAN
• UniProt AC: P25106
• Protein Name: Atypical chemokine receptor 3
• Gene Name: ACKR3
• Organism: Homo sapiens (Human).
• Sequence Length: 362
• Subcellular Localization: Cell membrane; Multi-pass membrane protein. Cytoplasm, perinuclear region. Early endosome. Recycling endosome. Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via clathrin-coated pits in a beta-arrest
• Protein Description: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates..
• Protein Sequence: MDLHLFDYSEPGNFSDISWPCNSSDCIVVDTVMCPNMPNKSVLLYTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYPEHSIKEWLIGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHYIPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYELMKAFIFKYSAKTGLTKLIDASRVSETEYSALEQSTK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	N-linked_Glycosylation	FDYSEPGNFSDISWP CCCCCCCCCCCCCCC		UniProtKB CARBOHYD
22	N-linked_Glycosylation	SDISWPCNSSDCIVV CCCCCCCCCCCEEEE		UniProtKB CARBOHYD
39	N-linked_Glycosylation	VMCPNMPNKSVLLYT EECCCCCCCHHHHHH		UniProtKB CARBOHYD
143	Phosphorylation	TCMSVDRYLSITYFT HHHCCCCCHHEEEEC		23663014
145	Phosphorylation	MSVDRYLSITYFTNT HCCCCCHHEEEECCC		23663014
147	Phosphorylation	VDRYLSITYFTNTPS CCCCHHEEEECCCHH		23663014
148	Phosphorylation	DRYLSITYFTNTPSS CCCHHEEEECCCHHH		23663014
150	Phosphorylation	YLSITYFTNTPSSRK CHHEEEECCCHHHHH		23663014
152	Phosphorylation	SITYFTNTPSSRKKM HEEEECCCHHHHHHH		23663014
154	Phosphorylation	TYFTNTPSSRKKMVR EEECCCHHHHHHHHH		23663014
155	Phosphorylation	YFTNTPSSRKKMVRR EECCCHHHHHHHHHH		23663014
328	Ubiquitination	NYRYELMKAFIFKYS HHHHHHHHHHHHHHH		23000965
333	Ubiquitination	LMKAFIFKYSAKTGL HHHHHHHHHHHCCCC		23000965
334	Phosphorylation	MKAFIFKYSAKTGLT HHHHHHHHHHCCCCC		19835603
335	Phosphorylation	KAFIFKYSAKTGLTK HHHHHHHHHCCCCCH		19835603
337	Ubiquitination	FIFKYSAKTGLTKLI HHHHHHHCCCCCHHH		25015289
338	Phosphorylation	IFKYSAKTGLTKLID HHHHHHCCCCCHHHC		19835603
342	Ubiquitination	SAKTGLTKLIDASRV HHCCCCCHHHCHHHC		23503661
347	Phosphorylation	LTKLIDASRVSETEY CCHHHCHHHCCHHHH		30266825
350	Phosphorylation	LIDASRVSETEYSAL HHCHHHCCHHHHHHH		19664994
352	Phosphorylation	DASRVSETEYSALEQ CHHHCCHHHHHHHHH		30266825
354	Phosphorylation	SRVSETEYSALEQST HHCCHHHHHHHHHHC		21955146
355	Phosphorylation	RVSETEYSALEQSTK HCCHHHHHHHHHHCC		30266825
360	Phosphorylation	EYSALEQSTK----- HHHHHHHHCC-----		23403867
361	Phosphorylation	YSALEQSTK------ HHHHHHHCC------		21955146
362	Ubiquitination	SALEQSTK------- HHHHHHCC-------		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ACKR3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ACKR3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ACKR3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ATPB_HUMAN	ATP5B	physical	26186194
ATPA_HUMAN	ATP5A1	physical	26186194
ATPD_HUMAN	ATP5D	physical	26186194
ATPO_HUMAN	ATP5O	physical	26186194
ATPA_HUMAN	ATP5A1	physical	26496610
ATPB_HUMAN	ATP5B	physical	26496610
ATPO_HUMAN	ATP5O	physical	26496610
ESPL1_HUMAN	ESPL1	physical	26496610
ATP5H_HUMAN	ATP5H	physical	26496610
RM04_HUMAN	MRPL4	physical	26496610
UBR7_HUMAN	UBR7	physical	26496610
HECD2_HUMAN	HECTD2	physical	26496610
ATPB_HUMAN	ATP5B	physical	28514442
ATPA_HUMAN	ATP5A1	physical	28514442
ATPO_HUMAN	ATP5O	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.