USH2A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: USH2A_HUMAN
• UniProt AC: O75445
• Protein Name: Usherin
• Gene Name: USH2A
• Organism: Homo sapiens (Human).
• Sequence Length: 5202
• Subcellular Localization: Cell projection, stereocilium membrane ; Single-pass type I membrane protein . Probable component of the interstereocilia ankle links in the inner ear sensory cells.; Isoform 2: Secreted.
• Protein Description: Involved in hearing and vision..
• Protein Sequence: MNCPVLSLGSGFLFQVIEMLIFAYFASISLTESRGLFPRLENVGAFKKVSIVPTQAVCGLPDRSTFCHSSAAAESIQFCTQRFCIQDCPYRSSHPTYTALFSAGLSSCITPDKNDLHPNAHSNSASFIFGNHKSCFSSPPSPKLMASFTLAVWLKPEQQGVMCVIEKTVDGQIVFKLTISEKETMFYYRTVNGLQPPIKVMTLGRILVKKWIHLSVQVHQTKISFFINGVEKDHTPFNARTLSGSITDFASGTVQIGQSLNGLEQFVGRMQDFRLYQVALTNREILEVFSGDLLRLHAQSHCRCPGSHPRVHPLAQRYCIPNDAGDTADNRVSRLNPEAHPLSFVNDNDVGTSWVSNVFTNITQLNQGVTISVDLENGQYQVFYIIIQFFSPQPTEIRIQRKKENSLDWEDWQYFARNCGAFGMKNNGDLEKPDSVNCLQLSNFTPYSRGNVTFSILTPGPNYRPGYNNFYNTPSLQEFVKATQIRFHFHGQYYTTETAVNLRHRYYAVDEITISGRCQCHGHADNCDTTSQPYRCLCSQESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQCNSHSKSCHYNISVDPFPFEHFRGGGGVCDDCEHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDCDTVGTRNGSILCDQIGGQCNCKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNCNTSGTVDGDITCHQNSGQCKCKANVIGLRCDHCNFGFKFLRSFNDVGCEPCQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDTCRENFYGLDVTNCKACDCDTAGSLPGTVCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQHCQMCECDSLGTLPGTICDPISGQCLCVPNRQGRRCNQCQPGFYISPGNATGCLPCSCHTTGAVNHICNSLTGQCVCQDASIAGQRCDQCKDHYFGFDPQTGRCQPCNCHLSGALNETCHLVTGQCFCKQFVTGSKCDACVPSASHLDVNNLLGCSKTPFQQPPPRGQVQSSSAINLSWSPPDSPNAHWLTYSLLRDGFEIYTTEDQYPYSIQYFLDTDLLPYTKYSYYIETTNVHGSTRSVAVTYKTKPGVPEGNLTLSYIIPIGSDSVTLTWTTLSNQSGPIEKYILSCAPLAGGQPCVSYEGHETSATIWNLVPFAKYDFSVQACTSGGCLHSLPITVTTAQAPPQRLSPPKMQKISSTELHVEWSPPAELNGIIIRYELYMRRLRSTKETTSEESRVFQSSGWLSPHSFVESANENALKPPQTMTTITGLEPYTKYEFRVLAVNMAGSVSSAWVSERTGESAPVFMIPPSVFPLSSYSLNISWEKPADNVTRGKVVGYDINMLSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFTITLCNSVGCVTSASGAGQTLAAAPAQLRPPLVKGINSTTIHLRWFPPEELNGPSPIYQLERRESSLPALMTTMMKGIRFIGNGYCKFPSSTHPVNTDFTGIKASFRTKVPEGLIVFAASPGNQEEYFALQLKKGRLYFLFDPQGSPVEVTTTNDHGKQYSDGKWHEIIAIRHQAFGQITLDGIYTGSSAILNGSTVIGDNTGVFLGGLPRSYTILRKDPEIIQKGFVGCLKDVHFMKNYNPSAIWEPLDWQSSEEQINVYNSWEGCPASLNEGAQFLGAGFLELHPYMFHGGMNFEISFKFRTDQLNGLLLFVYNKDGPDFLAMELKSGILTFRLNTSLAFTQVDLLLGLSYCNGKWNKVIIKKEGSFISASVNGLMKHASESGDQPLVVNSPVYVGGIPQELLNSYQHLCLEQGFGGCMKDVKFTRGAVVNLASVSSGAVRVNLDGCLSTDSAVNCRGNDSILVYQGKEQSVYEGGLQPFTEYLYRVIASHEGGSVYSDWSRGRTTGAAPQSVPTPSRVRSLNGYSIEVTWDEPVVRGVIEKYILKAYSEDSTRPPRMPSASAEFVNTSNLTGILTGLLPFKNYAVTLTACTLAGCTESSHALNISTPQEAPQEVQPPVAKSLPSSLLLSWNPPKKANGIITQYCLYMDGRLIYSGSEENYIVTDLAVFTPHQFLLSACTHVGCTNSSWVLLYTAQLPPEHVDSPVLTVLDSRTIHIQWKQPRKISGILERYVLYMSNHTHDFTIWSVIYNSTELFQDHMLQYVLPGNKYLIKLGACTGGGCTVSEASEALTDEDIPEGVPAPKAHSYSPDSFNVSWTEPEYPNGVITSYGLYLDGILIHNSSELSYRAYGFAPWSLHSFRVQACTAKGCALGPLVENRTLEAPPEGTVNVFVKTQGSRKAHVRWEAPFRPNGLLTHSVLFTGIFYVDPVGNNYTLLNVTKVMYSGEETNLWVLIDGLVPFTNYTVQVNISNSQGSLITDPITIAMPPGAPDGVLPPRLSSATPTSLQVVWSTPARNNAPGSPRYQLQMRSGDSTHGFLELFSNPSASLSYEVSDLQPYTEYMFRLVASNGFGSAHSSWIPFMTAEDKPGPVVPPILLDVKSRMMLVTWQHPRKSNGVITHYNIYLHGRLYLRTPGNVTNCTVMHLHPYTAYKFQVEACTSKGCSLSPESQTVWTLPGAPEGIPSPELFSDTPTSVIISWQPPTHPNGLVENFTIERRVKGKEEVTTLVTLPRSHSMRFIDKTSALSPWTKYEYRVLMSTLHGGTNSSAWVEVTTRPSRPAGVQPPVVTVLEPDAVQVTWKPPLIQNGDILSYEIHMPDPHITLTNVTSAVLSQKVTHLIPFTNYSVTIVACSGGNGYLGGCTESLPTYVTTHPTVPQNVGPLSVIPLSESYVVISWQPPSKPNGPNLRYELLRRKIQQPLASNPPEDLNRWHNIYSGTQWLYEDKGLSRFTTYEYMLFVHNSVGFTPSREVTVTTLAGLPERGANLTASVLNHTAIDVRWAKPTVQDLQGEVEYYTLFWSSATSNDSLKILPDVNSHVIGHLKPNTEYWIFISVFNGVHSINSAGLHATTCDGEPQGMLPPEVVIINSTAVRVIWTSPSNPNGVVTEYSIYVNNKLYKTGMNVPGSFILRDLSPFTIYDIQVEVCTIYACVKSNGTQITTVEDTPSDIPTPTIRGITSRSLQIDWVSPRKPNGIILGYDLLWKTWYPCAKTQKLVQDQSDELCKAVRCQKPESICGHICYSSEAKVCCNGVLYNPKPGHRCCEEKYIPFVLNSTGVCCGGRIQEAQPNHQCCSGYYARILPGEVCCPDEQHNRVSVGIGDSCCGRMPYSTSGNQICCAGRLHDGHGQKCCGRQIVSNDLECCGGEEGVVYNRLPGMFCCGQDYVNMSDTICCSASSGESKAHIKKNDPVPVKCCETELIPKSQKCCNGVGYNPLKYVCSDKISTGMMMKETKECRILCPASMEATEHCGRCDFNFTSHICTVIRGSHNSTGKASIEEMCSSAEETIHTGSVNTYSYTDVNLKPYMTYEYRISAWNSYGRGLSKAVRARTKEDVPQGVSPPTWTKIDNLEDTIVLNWRKPIQSNGPIIYYILLRNGIERFRGTSLSFSDKEGIQPFQEYSYQLKACTVAGCATSSKVVAATTQGVPESILPPSITALSAVALHLSWSVPEKSNGVIKEYQIRQVGKGLIHTDTTDRRQHTVTGLQPYTNYSFTLTACTSAGCTSSEPFLGQTLQAAPEGVWVTPRHIIINSTTVELYWSLPEKPNGLVSQYQLSRNGNLLFLGGSEEQNFTDKNLEPNSRYTYKLEVKTGGGSSASDDYIVQTPMSTPEEIYPPYNITVIGPYSIFVAWIPPGILIPEIPVEYNVLLNDGSVTPLAFSVGHHQSTLLENLTPFTQYEIRIQACQNGSCGVSSRMFVKTPEAAPMDLNSPVLKALGSACIEIKWMPPEKPNGIIINYFIYRRPAGIEEESVLFVWSEGALEFMDEGDTLRPFTLYEYRVRACNSKGSVESLWSLTQTLEAPPQDFPAPWAQATSAHSVLLNWTKPESPNGIISHYRVVYQERPDDPTFNSPTVHAFTVKGTSHQAHLYGLEPFTTYRIGVVAANHAGEILSPWTLIQTLESSPSGLRNFIVEQKENGRALLLQWSEPMRTNGVIKTYNIFSDGFLEYSGLNRQFLFRRLDPFTLYTLTLEACTRAGCAHSAPQPLWTDEAPPDSQLAPTVHSVKSTSVELSWSEPVNPNGKIIRYEVIRRCFEGKAWGNQTIQADEKIVFTEYNTERNTFMYNDTGLQPWTQCEYKIYTWNSAGHTCSSWNVVRTLQAPPEGLSPPVISYVSMNPQKLLISWIPPEQSNGIIQSYRLQRNEMLYPFSFDPVTFNYTDEELLPFSTYSYALQACTSGGCSTSKPTSITTLEAAPSEVSPPDLWAVSATQMNVCWSPPTVQNGKITKYLVRYDNKESLAGQGLCLLVSHLQPYSQYNFSLVACTNGGCTASVSKSAWTMEALPENMDSPTLQVTGSESIEITWKPPRNPNGQIRSYELRRDGTIVYTGLETRYRDFTLTPGVEYSYTVTASNSQGGILSPLVKDRTSPSAPSGMEPPKLQARGPQEILVNWDPPVRTNGDIINYTLFIRELFERETKIIHINTTHNSFGMQSYIVNQLKPFHRYEIRIQACTTLGCASSDWTFIQTPEIAPLMQPPPHLEVQMAPGGFQPTVSLLWTGPLQPNGKVLYYELYRRQIATQPRKSNPVLIYNGSSTSFIDSELLPFTEYEYQVWAVNSAGKAPSSWTWCRTGPAPPEGLRAPTFHVISSTQAVVNISAPGKPNGIVSLYRLFSSSAHGAETVLSEGMATQQTLHGLQAFTNYSIGVEACTCFNCCSKGPTAELRTHPAPPSGLSSPQIGTLASRTASFRWSPPMFPNGVIHSYELQFHVACPPDSALPCTPSQIETKYTGLGQKASLGGLQPYTTYKLRVVAHNEVGSTASEWISFTTQKELPQYRAPFSVDSNLSVVCVNWSDTFLLNGQLKEYVLTDGGRRVYSGLDTTLYIPRTADKTFFFQVICTTDEGSVKTPLIQYDTSTGLGLVLTTPGKKKGSRSKSTEFYSELWFIVLMAMLGLILLAIFLSLILQRKIHKEPYIRERPPLVPLQKRMSPLNVYPPGENHMGLADTKIPRSGTPVSIRSNRSACVLRIPSQNQTSLTYSQGSLHRSVSQLMDIQDKKVLMDNSLWEAIMGHNSGLYVDEEDLMNAIKDFSSVTKERTTFTDTHL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MNCPVLSLGSGFLF -CCCCEEECCCCHHH	30.80	24043423
10	Phosphorylation	CPVLSLGSGFLFQVI CCEEECCCCHHHHHH	31.50	24043423
24	Phosphorylation	IEMLIFAYFASISLT HHHHHHHHHHHCCCH	6.74	24043423
27	Phosphorylation	LIFAYFASISLTESR HHHHHHHHCCCHHCC	11.65	24043423
29	Phosphorylation	FAYFASISLTESRGL HHHHHHCCCHHCCCC	27.09	24043423
31	Phosphorylation	YFASISLTESRGLFP HHHHCCCHHCCCCCC	25.73	24043423
33	Phosphorylation	ASISLTESRGLFPRL HHCCCHHCCCCCCCC	26.81	24043423
147	Phosphorylation	PSPKLMASFTLAVWL CCHHHHEEEEEEEEC	12.56	-
361	N-linked_Glycosylation	WVSNVFTNITQLNQG HHHHHCCCCCCCCCC	24.68	UniProtKB CARBOHYD
451	N-linked_Glycosylation	FTPYSRGNVTFSILT CCCCCCCEEEEEEEC	28.66	UniProtKB CARBOHYD
463	Phosphorylation	ILTPGPNYRPGYNNF EECCCCCCCCCCCCC	22.71	18083107
467	Phosphorylation	GPNYRPGYNNFYNTP CCCCCCCCCCCCCCC	15.04	18083107
471	Phosphorylation	RPGYNNFYNTPSLQE CCCCCCCCCCCCHHH	21.90	18083107
529	Phosphorylation	GHADNCDTTSQPYRC CCCCCCCCCCCCEEE	30.46	-
530	Phosphorylation	HADNCDTTSQPYRCL CCCCCCCCCCCEEEE	16.47	-
531	Phosphorylation	ADNCDTTSQPYRCLC CCCCCCCCCCEEEEE	31.11	-
534	Phosphorylation	CDTTSQPYRCLCSQE CCCCCCCEEEEECCC	13.30	-
583	Phosphorylation	QCNSHSKSCHYNISV CCCCCCCCCEEECEE	14.78	-
586	Phosphorylation	SHSKSCHYNISVDPF CCCCCCEEECEECCC	20.65	-
587	N-linked_Glycosylation	HSKSCHYNISVDPFP CCCCCEEECEECCCC	9.08	UniProtKB CARBOHYD
589	Phosphorylation	KSCHYNISVDPFPFE CCCEEECEECCCCCC	19.48	-
611	N-linked_Glycosylation	VCDDCEHNTTGRNCE CCCCCCCCCCCCCCH	19.62	UniProtKB CARBOHYD
650	N-linked_Glycosylation	CDTVGTRNGSILCDQ CCCCCCCCCEEEECC	48.69	UniProtKB CARBOHYD
697	N-linked_Glycosylation	GCSPCNCNTSGTVDG CCCCCCCCCCCCCCC	24.24	UniProtKB CARBOHYD
839	N-linked_Glycosylation	GNFYLRQNNSFLCLP CCEEECCCCEEEEEE	39.41	UniProtKB CARBOHYD
856	N-linked_Glycosylation	CDKTGTINGSLLCNK CCCCCEECCEEEECC	33.56	UniProtKB CARBOHYD
862	N-linked_Glycosylation	INGSLLCNKSTGQCP ECCEEEECCCCCCCC	41.08	UniProtKB CARBOHYD
864	Phosphorylation	GSLLCNKSTGQCPCK CEEEECCCCCCCCCE	24.63	-
865	Phosphorylation	SLLCNKSTGQCPCKL EEEECCCCCCCCCEE	32.64	-
875	Phosphorylation	CPCKLGVTGLRCNQC CCCEECCCCEECCCC	28.80	23403867
888	N-linked_Glycosylation	QCEPHRYNLTIDNFQ CCCCCCCEEEECCCC	30.57	UniProtKB CARBOHYD
944	N-linked_Glycosylation	GFYISPGNATGCLPC CEEECCCCCCCEEEC	37.40	UniProtKB CARBOHYD
1011	N-linked_Glycosylation	CHLSGALNETCHLVT CCCCCCCCCCEEEEC	41.83	UniProtKB CARBOHYD
1071	N-linked_Glycosylation	VQSSSAINLSWSPPD CCCCCCEEECCCCCC	27.95	UniProtKB CARBOHYD
1151	N-linked_Glycosylation	KPGVPEGNLTLSYII CCCCCCCCEEEEEEE	28.35	UniProtKB CARBOHYD
1174	N-linked_Glycosylation	LTWTTLSNQSGPIEK EEEEECCCCCCCCEE	43.05	UniProtKB CARBOHYD
1247	Phosphorylation	QAPPQRLSPPKMQKI CCCCCCCCCCCCCCC	41.15	24719451
1256	Phosphorylation	PKMQKISSTELHVEW CCCCCCCCCEEEEEE	29.40	-
1290	Phosphorylation	LRSTKETTSEESRVF HHCCCCCCCHHHHHH	34.92	17693683
1322	Phosphorylation	NALKPPQTMTTITGL CCCCCCCCEEEECCC	23.43	25072903
1324	Phosphorylation	LKPPQTMTTITGLEP CCCCCCEEEECCCCC	20.59	25072903
1325	Phosphorylation	KPPQTMTTITGLEPY CCCCCEEEECCCCCC	13.01	25072903
1327	Phosphorylation	PQTMTTITGLEPYTK CCCEEEECCCCCCCC	33.35	25072903
1332	Phosphorylation	TITGLEPYTKYEFRV EECCCCCCCCEEEEE	13.39	25072903
1333	Phosphorylation	ITGLEPYTKYEFRVL ECCCCCCCCEEEEEE	37.55	25072903
1379	N-linked_Glycosylation	PLSSYSLNISWEKPA CCCCCEEECEECCCC	21.95	UniProtKB CARBOHYD
1388	N-linked_Glycosylation	SWEKPADNVTRGKVV EECCCCCCCCCCEEE	38.88	UniProtKB CARBOHYD
1424	Phosphorylation	QLLHTAKSQELSYTV HHHHHHHHCCCEEEE	26.82	17081983
1479	N-linked_Glycosylation	PPLVKGINSTTIHLR CCCCCCCCCCEEEEE	41.81	UniProtKB CARBOHYD
1507	Phosphorylation	YQLERRESSLPALMT HHHHHHHCCHHHHHH	35.05	24275569
1508	Phosphorylation	QLERRESSLPALMTT HHHHHHCCHHHHHHH	33.35	25002506
1514	Phosphorylation	SSLPALMTTMMKGIR CCHHHHHHHHHCCCE	16.64	25002506
1515	Phosphorylation	SLPALMTTMMKGIRF CHHHHHHHHHCCCEE	10.99	25002506
1527	Phosphorylation	IRFIGNGYCKFPSST CEEECCCCCCCCCCC	9.10	-
1635	N-linked_Glycosylation	TGSSAILNGSTVIGD ECCCEEECCCEEECC	35.93	UniProtKB CARBOHYD
1660	Ubiquitination	RSYTILRKDPEIIQK CCEEEECCCHHHHHC	74.35	-
1660 (in isoform 3)	Ubiquitination	-	74.35	-
1741	Phosphorylation	GGMNFEISFKFRTDQ CCCCEEEEEEEEHHH	18.39	24719451
1779	N-linked_Glycosylation	GILTFRLNTSLAFTQ CEEEEECCCCCHHHH	24.30	UniProtKB CARBOHYD
1810	Phosphorylation	VIIKKEGSFISASVN EEEECCCCCEEEEHH	22.09	30206219
1813	Phosphorylation	KKEGSFISASVNGLM ECCCCCEEEEHHHHH	16.69	30206219
1815	Phosphorylation	EGSFISASVNGLMKH CCCCEEEEHHHHHHH	14.88	30206219
1903	N-linked_Glycosylation	SAVNCRGNDSILVYQ CCCCCCCCCEEEEEE	22.09	UniProtKB CARBOHYD
1909	Phosphorylation	GNDSILVYQGKEQSV CCCEEEEEECCCEEC	14.22	-
1917	Phosphorylation	QGKEQSVYEGGLQPF ECCCEECCCCCCCCH	17.69	-
1925	Phosphorylation	EGGLQPFTEYLYRVI CCCCCCHHHHHHHHH	30.33	-
1927	Phosphorylation	GLQPFTEYLYRVIAS CCCCHHHHHHHHHHC	13.13	-
1949	Phosphorylation	SDWSRGRTTGAAPQS ECCCCCCCCCCCCCC	32.19	-
1950	Phosphorylation	DWSRGRTTGAAPQSV CCCCCCCCCCCCCCC	24.38	-
1961	Phosphorylation	PQSVPTPSRVRSLNG CCCCCCCHHCEECCC	45.98	-
2006	Phosphorylation	PPRMPSASAEFVNTS CCCCCCCCEEEECCC	32.44	19690332
2011	N-linked_Glycosylation	SASAEFVNTSNLTGI CCCEEEECCCCCCHH	43.01	UniProtKB CARBOHYD
2012	Phosphorylation	ASAEFVNTSNLTGIL CCEEEECCCCCCHHH	17.43	19690332
2014	N-linked_Glycosylation	AEFVNTSNLTGILTG EEEECCCCCCHHHHC	39.31	UniProtKB CARBOHYD
2048	N-linked_Glycosylation	TESSHALNISTPQEA CCCCCCCCCCCCCCC	27.27	UniProtKB CARBOHYD
2130	N-linked_Glycosylation	CTHVGCTNSSWVLLY CCEECCCCCEEEEEE	37.82	UniProtKB CARBOHYD
2182	N-linked_Glycosylation	RYVLYMSNHTHDFTI HHHHHHCCCCCCEEE	27.78	UniProtKB CARBOHYD
2195	N-linked_Glycosylation	TIWSVIYNSTELFQD EEEEEEECCHHHHHH	31.19	UniProtKB CARBOHYD
2258	N-linked_Glycosylation	SYSPDSFNVSWTEPE CCCCCCCEECCCCCC	30.75	UniProtKB CARBOHYD
2285	N-linked_Glycosylation	LDGILIHNSSELSYR EEEEEEECCCCCCCC	39.99	UniProtKB CARBOHYD
2322	N-linked_Glycosylation	ALGPLVENRTLEAPP CCCCEEECCEEECCC	34.45	UniProtKB CARBOHYD
2377	N-linked_Glycosylation	YVDPVGNNYTLLNVT EECCCCCCEEEEEEE	25.82	UniProtKB CARBOHYD
2382	N-linked_Glycosylation	GNNYTLLNVTKVMYS CCCEEEEEEEEEEEC	42.39	UniProtKB CARBOHYD
2407	N-linked_Glycosylation	DGLVPFTNYTVQVNI ECCCCCCCEEEEEEE	30.75	UniProtKB CARBOHYD
2413	N-linked_Glycosylation	TNYTVQVNISNSQGS CCEEEEEEEECCCCC	18.19	UniProtKB CARBOHYD
2466	Phosphorylation	ARNNAPGSPRYQLQM CCCCCCCCCCEEEEE	12.73	20860994
2546	Phosphorylation	PILLDVKSRMMLVTW CEEEECCCCEEEEEE	25.84	-
2552	Phosphorylation	KSRMMLVTWQHPRKS CCCEEEEEECCCCCC	18.55	28270605
2581	N-linked_Glycosylation	LYLRTPGNVTNCTVM EEECCCCCCCCEEEE	38.35	UniProtKB CARBOHYD
2584	N-linked_Glycosylation	RTPGNVTNCTVMHLH CCCCCCCCEEEEECC	18.38	UniProtKB CARBOHYD
2656	N-linked_Glycosylation	HPNGLVENFTIERRV CCCCCCCCCEEEEEC	31.70	UniProtKB CARBOHYD
2670	Phosphorylation	VKGKEEVTTLVTLPR CCCCCEEEEEEEECC	20.07	23663014
2671	Phosphorylation	KGKEEVTTLVTLPRS CCCCEEEEEEEECCC	25.14	23663014
2674	Phosphorylation	EEVTTLVTLPRSHSM CEEEEEEEECCCCCC	33.87	23663014
2678	Phosphorylation	TLVTLPRSHSMRFID EEEEECCCCCCCCEE	20.27	23663014
2680	Phosphorylation	VTLPRSHSMRFIDKT EEECCCCCCCCEECC	16.95	23663014
2687	Phosphorylation	SMRFIDKTSALSPWT CCCCEECCCCCCCCC	18.58	29083192
2688	Phosphorylation	MRFIDKTSALSPWTK CCCEECCCCCCCCCH	32.71	29083192
2691	Phosphorylation	IDKTSALSPWTKYEY EECCCCCCCCCHHHH	20.36	29083192
2694	Phosphorylation	TSALSPWTKYEYRVL CCCCCCCCHHHHHHH	27.42	29083192
2710	N-linked_Glycosylation	STLHGGTNSSAWVEV HHHCCCCCCCCEEEE	36.92	UniProtKB CARBOHYD
2770	N-linked_Glycosylation	DPHITLTNVTSAVLS CCCEEEECCHHHHHC	37.88	UniProtKB CARBOHYD
2788	N-linked_Glycosylation	THLIPFTNYSVTIVA CEECCCCCCEEEEEE	27.71	UniProtKB CARBOHYD
2911	Phosphorylation	VHNSVGFTPSREVTV ECCCCCCCCCCEEEE	17.90	-
2919	Phosphorylation	PSREVTVTTLAGLPE CCCEEEEEEECCCCC	13.51	-
2920	Phosphorylation	SREVTVTTLAGLPER CCEEEEEEECCCCCC	15.41	-
2930	N-linked_Glycosylation	GLPERGANLTASVLN CCCCCCCCCHHHHHC	40.52	UniProtKB CARBOHYD
2937	N-linked_Glycosylation	NLTASVLNHTAIDVR CCHHHHHCCCEEEEE	28.45	UniProtKB CARBOHYD
2970	N-linked_Glycosylation	FWSSATSNDSLKILP EEECCCCCCCCEECC	38.24	UniProtKB CARBOHYD
3032	N-linked_Glycosylation	PPEVVIINSTAVRVI CCEEEEEECCEEEEE	23.37	UniProtKB CARBOHYD
3064	Phosphorylation	VNNKLYKTGMNVPGS ECCEECCCCCCCCCC	28.27	19413330
3071	Phosphorylation	TGMNVPGSFILRDLS CCCCCCCCEEECCCC	11.75	19413330
3099	N-linked_Glycosylation	IYACVKSNGTQITTV EEEEECCCCCEEEEE	52.38	UniProtKB CARBOHYD
3211	Phosphorylation	HRCCEEKYIPFVLNS CCCCCCCCCCEEECC	19.67	28387310
3217	N-linked_Glycosylation	KYIPFVLNSTGVCCG CCCCEEECCCCCCCC	32.02	UniProtKB CARBOHYD
3330	N-linked_Glycosylation	CCGQDYVNMSDTICC ECCCCCCCCCCCEEE	20.29	UniProtKB CARBOHYD
3419	N-linked_Glycosylation	HCGRCDFNFTSHICT CCCCCCCCCCCCEEE	26.49	UniProtKB CARBOHYD
3433	N-linked_Glycosylation	TVIRGSHNSTGKASI EEEECCCCCCCCCCH	42.85	UniProtKB CARBOHYD
3487	Phosphorylation	NSYGRGLSKAVRART HHCCCCHHHHHHHHC	22.76	26029660
3494	Phosphorylation	SKAVRARTKEDVPQG HHHHHHHCCCCCCCC	37.49	29083192
3503	Phosphorylation	EDVPQGVSPPTWTKI CCCCCCCCCCCCCCC	31.80	23403867
3506	Phosphorylation	PQGVSPPTWTKIDNL CCCCCCCCCCCCCCC	49.50	23403867
3508	Phosphorylation	GVSPPTWTKIDNLED CCCCCCCCCCCCCCC	22.17	29083192
3611	Phosphorylation	VALHLSWSVPEKSNG HHHHHHCCCCCCCCC	25.15	-
3616	Phosphorylation	SWSVPEKSNGVIKEY HCCCCCCCCCCEEEE	36.83	-
3623	Phosphorylation	SNGVIKEYQIRQVGK CCCCEEEEEEEEECC	12.30	-
3635	Phosphorylation	VGKGLIHTDTTDRRQ ECCCCCCCCCCCCCC	28.22	24670416
3637	Phosphorylation	KGLIHTDTTDRRQHT CCCCCCCCCCCCCCE	31.58	24670416
3638	Phosphorylation	GLIHTDTTDRRQHTV CCCCCCCCCCCCCEE	30.25	24670416
3653	N-linked_Glycosylation	TGLQPYTNYSFTLTA CCCCCCCCEEEEEEE	25.30	UniProtKB CARBOHYD
3694	N-linked_Glycosylation	TPRHIIINSTTVELY CCCEEEECCCEEEEE	23.93	UniProtKB CARBOHYD
3733	N-linked_Glycosylation	LGGSEEQNFTDKNLE ECCCCCCCCCCCCCC	45.10	UniProtKB CARBOHYD
3745	Phosphorylation	NLEPNSRYTYKLEVK CCCCCCCEEEEEEEE	17.78	-
3747	Phosphorylation	EPNSRYTYKLEVKTG CCCCCEEEEEEEEEC	12.49	-
3780	N-linked_Glycosylation	EEIYPPYNITVIGPY HHHCCCCEEEEEECC	29.27	UniProtKB CARBOHYD
3849	N-linked_Glycosylation	IRIQACQNGSCGVSS EEEEHHHCCCCCCCC	44.20	UniProtKB CARBOHYD
3984	N-linked_Glycosylation	SAHSVLLNWTKPESP CCCEEEECCCCCCCC	39.96	UniProtKB CARBOHYD
4065	Phosphorylation	LIQTLESSPSGLRNF HHHHHHCCCCCHHCE	17.45	26699800
4067	Phosphorylation	QTLESSPSGLRNFIV HHHHCCCCCHHCEEE	53.02	26699800
4202	N-linked_Glycosylation	FEGKAWGNQTIQADE HCCCCCCCCEECCCC	25.72	UniProtKB CARBOHYD
4226	N-linked_Glycosylation	ERNTFMYNDTGLQPW CCCEEECCCCCCCCC	28.69	UniProtKB CARBOHYD
4317	N-linked_Glycosylation	SFDPVTFNYTDEELL CCCCEECCCCCCCCC	29.45	UniProtKB CARBOHYD
4418	N-linked_Glycosylation	LQPYSQYNFSLVACT CCCCCCCCEEEEEEC	16.64	UniProtKB CARBOHYD
4487	Phosphorylation	RRDGTIVYTGLETRY CCCCEEEEECCCEEE	7.40	-
4520	Phosphorylation	NSQGGILSPLVKDRT CCCCCEECCEECCCC	17.80	24719451
4527	Phosphorylation	SPLVKDRTSPSAPSG CCEECCCCCCCCCCC	55.94	28450419
4528	Phosphorylation	PLVKDRTSPSAPSGM CEECCCCCCCCCCCC	20.11	28450419
4564	N-linked_Glycosylation	RTNGDIINYTLFIRE CCCCCEEEHHHHHHH	24.87	UniProtKB CARBOHYD
4583	N-linked_Glycosylation	ETKIIHINTTHNSFG CCEEEEEECCCCCCC	25.43	UniProtKB CARBOHYD
4585	Phosphorylation	KIIHINTTHNSFGMQ EEEEEECCCCCCCCC	17.99	30576142
4691	N-linked_Glycosylation	SNPVLIYNGSSTSFI CCCEEEECCCCCCCC	36.56	UniProtKB CARBOHYD
4754	N-linked_Glycosylation	SSTQAVVNISAPGKP ECCCEEEEECCCCCC	18.85	UniProtKB CARBOHYD
4800	N-linked_Glycosylation	HGLQAFTNYSIGVEA HHHHHHCCEECEEEE	23.31	UniProtKB CARBOHYD
4895	Phosphorylation	TGLGQKASLGGLQPY CCCCCCCCCCCCCCC	34.28	-
4943	N-linked_Glycosylation	APFSVDSNLSVVCVN CCCCCCCCCEEEEEC	31.69	UniProtKB CARBOHYD
4950	N-linked_Glycosylation	NLSVVCVNWSDTFLL CCEEEEECCCCEEEE	27.66	UniProtKB CARBOHYD
4986	Phosphorylation	TTLYIPRTADKTFFF CEEEEECCCCCEEEE	33.58	28787133
5011	Phosphorylation	VKTPLIQYDTSTGLG EECCEEEEECCCCCE	17.75	-
5013	Phosphorylation	TPLIQYDTSTGLGLV CCEEEEECCCCCEEE	24.21	-
5039	Phosphorylation	SKSTEFYSELWFIVL CCCHHHHHHHHHHHH	31.37	-
5060	Phosphorylation	ILLAIFLSLILQRKI HHHHHHHHHHHHHHH	11.56	-
5087	Phosphorylation	VPLQKRMSPLNVYPP CCCCCCCCCCCCCCC	30.21	-
5092	Phosphorylation	RMSPLNVYPPGENHM CCCCCCCCCCCCCCC	11.57	-
5104	Phosphorylation	NHMGLADTKIPRSGT CCCCCCCCCCCCCCC	25.85	-
5128	Phosphorylation	ACVLRIPSQNQTSLT EEEEECCCCCCCEEE	39.12	24043423
5132	Phosphorylation	RIPSQNQTSLTYSQG ECCCCCCCEEEECCC	33.00	24043423
5133	Phosphorylation	IPSQNQTSLTYSQGS CCCCCCCEEEECCCC	14.67	22210691
5135	Phosphorylation	SQNQTSLTYSQGSLH CCCCCEEEECCCCCC	22.39	24043423
5136	Phosphorylation	QNQTSLTYSQGSLHR CCCCEEEECCCCCCC	12.32	22210691
5137	Phosphorylation	NQTSLTYSQGSLHRS CCCEEEECCCCCCCC	23.88	24043423
5140	Phosphorylation	SLTYSQGSLHRSVSQ EEEECCCCCCCCHHH	17.23	24043423
5195	Phosphorylation	SSVTKERTTFTDTHL HHCCCCCCCCCCCCC	27.61	24043423
5196	Phosphorylation	SVTKERTTFTDTHL- HCCCCCCCCCCCCC-	30.66	24043423
5198	Phosphorylation	TKERTTFTDTHL--- CCCCCCCCCCCC---	37.59	24043423
5200	Phosphorylation	ERTTFTDTHL----- CCCCCCCCCC-----	23.24	24043423

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of USH2A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of USH2A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of USH2A_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of USH2A_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• H00527: Retinitis pigmentosa (RP)
• H00779: Usher syndrome (US)
• OMIM Disease
• 276901: Usher syndrome 2A (USH2A)
• 613809: Retinitis pigmentosa 39 (RP39)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-3064 AND SER-3071, ANDMASS SPECTROMETRY.
PubMed: 19413330

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1424, AND MASSSPECTROMETRY.
PubMed: 17081983

"Quantitative phosphoproteome profiling of Wnt3a-mediated signalingnetwork: indicating the involvement of ribonucleoside-diphosphatereductase M2 subunit phosphorylation at residue serine 20 in canonicalWnt signal transduction.";
Tang L.-Y., Deng N., Wang L.-S., Dai J., Wang Z.-L., Jiang X.-S.,Li S.-J., Li L., Sheng Q.-H., Wu D.-Q., Li L., Zeng R.;
Mol. Cell. Proteomics 6:1952-1967(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1290, AND MASSSPECTROMETRY.
PubMed: 17693683