MIA2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MIA2_HUMAN
• UniProt AC: Q96PC5
• Protein Name: Melanoma inhibitory activity protein 2 {ECO:0000305}
• Gene Name: MIA2 {ECO:0000312|HGNC:HGNC:18432}
• Organism: Homo sapiens (Human).
• Sequence Length: 1412
• Subcellular Localization: Isoform 1: Endoplasmic reticulum membrane ; Single-pass membrane protein . Endoplasmic reticulum exit sites.
• Protein Description: Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. Isoform 1 plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum. [PubMed: 27138255 Thereby, may play a role in cholesterol and triglyceride homeostasis (By similarity]
• Protein Sequence: MAKFGVHRILLLAISLTKCLESTKLLADLKKCGDLECEALINRVSAMRDYRGPDCRYLNFTKGEEISVYVKLAGEREDLWAGSKGKEFGYFPRDAVQIEEVFISEEIQMSTKESDFLCLLGVSYTFDNEDSELNGDYGENIYPYEEDKDEKSSIYESDFQIEPGFYATYESTLFEDQVPALEAPEDIGSTSESKDWEEVVVESMEQDRIPEVHVPPSSAVSGVKEWFGLGGEQAEEKAFESVIEPVQESSFRSRKIAVEDENDLEELNNGEPQTEHQQESESEIDSVPKTQSELASESEHIPKPQSTGWFGGGFTSYLGFGDEDTGLELIAEESNPPLQDFPNSISSDKEATVPCTEILTEKKDTITNDSLSLKPSWFDFGFAILGFAYAKEDKIMLDDRKNEEDGGADEHEHPLTSELDPEKEQEIETIKIIETEDQIDKKPVSEKTDESDTIPYLKKFLYNFDNPWNFQNIPKETELPFPKQILDQNNVIENEETGEFSIDNYPTDNTKVMIFKSSYSLSDMVSNIELPTRIHEEVYFEPSSSKDSDENSKPSVDTEGPALVEIDRSVENTLLNSQMVSTDNSLSSQNYISQKEDASEFQILKYLFQIDVYDFMNSAFSPIVILTERVVAALPEGMRPDSNLYGFPWELVICAAVVGFFAVLFFLWRSFRSVRSRLYVGREKKLALMLSGLIEEKSKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEKLNRSNSELEDEILCLEKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQMNEERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQVLNDKESHIKTLTERLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGALKKLIHAAKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFENENQKLQQKLKVMTELYQENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHATEELETYRKRAKDLEEELERTIHSYQGQIISHEKKAHDNWLAARNAERNLNDLRKENAHNRQKLTETELKFELLEKDPYALDVPNTAFGREHSPYGPSPLGWPSSETRAFLSPPTLLEGPLRLSPLLPGGGGRGSRGPGNPLDHQITNERGESSCDRLTDPHRAPSDTGSLSPPWDQDRRMMFPPPGQSYPDSALPPQRQDRFCSNSGRLSGPAELRSFNMPSLDKMDGSMPSEMESSRNDTKDDLGNLNVPDSSLPAENEATGPGFVPPPLAPIRGPLFPVDARGPFLRRGPPFPPPPPGAMFGASRDYFPPGDFPGPPPAPFAMRNVYPPRGFPPYLPPRPGFFPPPPHSEGRSEFPSGLIPPSNEPATEHPEPQQET

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	RILLLAISLTKCLES HHHHHHHHHHHHHHH	25.12	24719451
59	N-linked_Glycosylation	GPDCRYLNFTKGEEI CCCCCEECCCCCCEE	33.34	UniProtKB CARBOHYD
62	Phosphorylation	CRYLNFTKGEEISVY CCEECCCCCCEEEEE	61.25	20068231
65	Phosphorylation	LNFTKGEEISVYVKL ECCCCCCEEEEEEEE	49.59	24719451
71	Phosphorylation	EEISVYVKLAGERED CEEEEEEEECCCCCC	18.22	24719451
95	Ubiquitination	FGYFPRDAVQIEEVF CCCCCCCCCEEEEEE	9.08	-
97	Phosphorylation	YFPRDAVQIEEVFIS CCCCCCCEEEEEEEC	38.81	29396449
99 (in isoform 9)	Phosphorylation	-	30.89	29743597
103	Phosphorylation	VQIEEVFISEEIQMS CEEEEEEECHHHHCC	6.47	28796482
106	Phosphorylation	EEVFISEEIQMSTKE EEEEECHHHHCCCCC	31.56	28796482
110	Phosphorylation	ISEEIQMSTKESDFL ECHHHHCCCCCCCCE	21.68	30108239
111	Phosphorylation	SEEIQMSTKESDFLC CHHHHCCCCCCCCEE	33.22	30108239
116	Phosphorylation	MSTKESDFLCLLGVS CCCCCCCCEEECCEE	7.85	23663014
122	Phosphorylation	DFLCLLGVSYTFDNE CCEEECCEEEEECCC	3.89	23663014
126	Phosphorylation	LLGVSYTFDNEDSEL ECCEEEEECCCCCCC	7.83	21815630
137	Phosphorylation	DSELNGDYGENIYPY CCCCCCCCCCCCCCC	27.95	25159151
139	Phosphorylation	ELNGDYGENIYPYEE CCCCCCCCCCCCCCC	33.94	25159151
142	Phosphorylation	GDYGENIYPYEEDKD CCCCCCCCCCCCCCC	16.02	20068231
144	Phosphorylation	YGENIYPYEEDKDEK CCCCCCCCCCCCCCC	18.25	18669648
157	Phosphorylation	EKSSIYESDFQIEPG CCCCCCCCCCCCCCC	27.10	29759185
166	Phosphorylation	FQIEPGFYATYESTL CCCCCCCEEEEECCC	12.16	29759185
168	Phosphorylation	IEPGFYATYESTLFE CCCCCEEEEECCCCC	19.22	29759185
169	Phosphorylation	EPGFYATYESTLFED CCCCEEEEECCCCCC	10.34	29759185
175	Phosphorylation	TYESTLFEDQVPALE EEECCCCCCCCCCCC	51.12	21815630
180	Phosphorylation	LFEDQVPALEAPEDI CCCCCCCCCCCCCCC	21.12	23312004
182	Phosphorylation	EDQVPALEAPEDIGS CCCCCCCCCCCCCCC	65.37	23312004
217	O-linked_Glycosylation	PEVHVPPSSAVSGVK CCCCCCCHHHCCCHH	25.51	OGP
249	Phosphorylation	VIEPVQESSFRSRKI HCHHHHHCCCCCCCE	20.06	22468782
249	Phosphorylation	VIEPVQESSFRSRKI HCHHHHHCCCCCCCE	20.06	20068231
250	Phosphorylation	IEPVQESSFRSRKIA CHHHHHCCCCCCCEE	24.75	20068231
253	Phosphorylation	VQESSFRSRKIAVED HHHCCCCCCCEEECC	35.60	20068231
292	Phosphorylation	DSVPKTQSELASESE CCCCCHHHHHHHCCC	39.55	-
325	O-linked_Glycosylation	LGFGDEDTGLELIAE CCCCCCCCCEEEEEC	41.43	25367160
368	N-linked_Glycosylation	EKKDTITNDSLSLKP CCCCCCCCCCCCCCC	32.78	UniProtKB CARBOHYD
370	Phosphorylation	KDTITNDSLSLKPSW CCCCCCCCCCCCCCH	23.17	24719451
372	Phosphorylation	TITNDSLSLKPSWFD CCCCCCCCCCCCHHH	38.00	24719451
401	Phosphorylation	KIMLDDRKNEEDGGA CEECCCCCCCCCCCC	75.58	27273156
406	Phosphorylation	DRKNEEDGGADEHEH CCCCCCCCCCCCCCC	36.15	-
430	Phosphorylation	KEQEIETIKIIETED HHHHCEEEEEEECCH	1.63	-
431	Phosphorylation	EQEIETIKIIETEDQ HHHCEEEEEEECCHH	45.08	-
435	Phosphorylation	ETIKIIETEDQIDKK EEEEEEECCHHCCCC	34.16	-
455	Phosphorylation	TDESDTIPYLKKFLY CCCCCCHHHHHHHHH	30.42	28555341
474 (in isoform 7)	Phosphorylation	-	35.66	24719451
481 (in isoform 7)	Phosphorylation	-	21.59	28348404
487 (in isoform 7)	Phosphorylation	-	51.28	27050516
499 (in isoform 7)	Phosphorylation	-	43.57	24719451
503	Phosphorylation	ETGEFSIDNYPTDNT CCCCEEECCCCCCCC	47.62	29978859
510	Phosphorylation	DNYPTDNTKVMIFKS CCCCCCCCEEEEEEC	28.03	27273156
510 (in isoform 2)	Phosphorylation	-	28.03	28348404
517	Phosphorylation	TKVMIFKSSYSLSDM CEEEEEECCCCHHHH	24.61	23401153
519	Phosphorylation	VMIFKSSYSLSDMVS EEEEECCCCHHHHHH	22.26	23927012
522	Phosphorylation	FKSSYSLSDMVSNIE EECCCCHHHHHHCCC	22.72	25159151
522	Phosphorylation	FKSSYSLSDMVSNIE EECCCCHHHHHHCCC	22.72	19651622
524	Phosphorylation	SSYSLSDMVSNIELP CCCCHHHHHHCCCCC	8.22	19651622
527	Phosphorylation	SLSDMVSNIELPTRI CHHHHHHCCCCCCCC	19.37	19651622
528	Phosphorylation	LSDMVSNIELPTRIH HHHHHHCCCCCCCCE	1.70	23403867
529	Phosphorylation	SDMVSNIELPTRIHE HHHHHCCCCCCCCEE	8.84	23403867
531	Phosphorylation	MVSNIELPTRIHEEV HHHCCCCCCCCEEEE	10.69	23090842
536	Phosphorylation	ELPTRIHEEVYFEPS CCCCCCEEEEECCCC	4.76	29255136
539	Phosphorylation	TRIHEEVYFEPSSSK CCCEEEEECCCCCCC	32.83	30266825
541	Phosphorylation	IHEEVYFEPSSSKDS CEEEEECCCCCCCCC	10.38	20068231
544	Phosphorylation	EVYFEPSSSKDSDEN EEECCCCCCCCCCCC		18669648
548	Phosphorylation	EPSSSKDSDENSKPS CCCCCCCCCCCCCCC		29255136
553	Phosphorylation	KDSDENSKPSVDTEG CCCCCCCCCCCCCCC		19651622
559	Phosphorylation	SKPSVDTEGPALVEI CCCCCCCCCCCEEEE		29255136
564	Phosphorylation	DTEGPALVEIDRSVE CCCCCCEEEEECHHH		19651622
569	Phosphorylation	ALVEIDRSVENTLLN CEEEEECHHHHHHHC		22210691
571	Phosphorylation	VEIDRSVENTLLNSQ EEEECHHHHHHHCCE		23312004
577	Phosphorylation	VENTLLNSQMVSTDN HHHHHHCCEECCCCC		25850435
578	Phosphorylation	ENTLLNSQMVSTDNS HHHHHCCEECCCCCC		25850435
583	Phosphorylation	NSQMVSTDNSLSSQN CCEECCCCCCCCCCC		23927012
587	Phosphorylation	VSTDNSLSSQNYISQ CCCCCCCCCCCCCCC		22210691
588	Phosphorylation	STDNSLSSQNYISQK CCCCCCCCCCCCCCC		17081983
590	Phosphorylation	DNSLSSQNYISQKED CCCCCCCCCCCCCCC		30266825
591	Phosphorylation	NSLSSQNYISQKEDA CCCCCCCCCCCCCCH		22210691
592	Phosphorylation	SLSSQNYISQKEDAS CCCCCCCCCCCCCHH		30266825
593	Phosphorylation	LSSQNYISQKEDASE CCCCCCCCCCCCHHH		-
594	Phosphorylation	SSQNYISQKEDASEF CCCCCCCCCCCHHHH		23927012
595	Phosphorylation	SQNYISQKEDASEFQ CCCCCCCCCCHHHHH		17081983
596	Phosphorylation	QNYISQKEDASEFQI CCCCCCCCCHHHHHH		23927012
597 (in isoform 9)	Phosphorylation	-		29743597
597	Phosphorylation	NYISQKEDASEFQIL CCCCCCCCHHHHHHH		17081983
599	Phosphorylation	ISQKEDASEFQILKY CCCCCCHHHHHHHHH		17081983
601	Phosphorylation	QKEDASEFQILKYLF CCCCHHHHHHHHHHH		17081983
613	Phosphorylation	YLFQIDVYDFMNSAF HHHHCCHHHHHHCCC		24275569
614	Phosphorylation	LFQIDVYDFMNSAFS HHHCCHHHHHHCCCC		24275569
629	Phosphorylation	PIVILTERVVAALPE CEEEEEHHHHHHCCC		23927012
631	Phosphorylation	VILTERVVAALPEGM EEEEHHHHHHCCCCC		23927012
635	Phosphorylation	ERVVAALPEGMRPDS HHHHHHCCCCCCCCC		29255136
636	Phosphorylation	RVVAALPEGMRPDSN HHHHHCCCCCCCCCC		20068231
640	Phosphorylation	ALPEGMRPDSNLYGF HCCCCCCCCCCCCCC		17081983
642	Phosphorylation	PEGMRPDSNLYGFPW CCCCCCCCCCCCCCH		23927012
647	Phosphorylation	PDSNLYGFPWELVIC CCCCCCCCCHHHHHH		23927012
652	Phosphorylation	YGFPWELVICAAVVG CCCCHHHHHHHHHHH		19651622
654	Phosphorylation	FPWELVICAAVVGFF CCHHHHHHHHHHHHH		23401153
657	Phosphorylation	ELVICAAVVGFFAVL HHHHHHHHHHHHHHH		29083192
661	Phosphorylation	CAAVVGFFAVLFFLW HHHHHHHHHHHHHHH		30576142
662	Phosphorylation	AAVVGFFAVLFFLWR HHHHHHHHHHHHHHH		22115753
666	Phosphorylation	GFFAVLFFLWRSFRS HHHHHHHHHHHHHHH		22115753
670	Phosphorylation	VLFFLWRSFRSVRSR HHHHHHHHHHHHHHH		20068231
673	Phosphorylation	FLWRSFRSVRSRLYV HHHHHHHHHHHHHCC		24719451
678	Phosphorylation	FRSVRSRLYVGREKK HHHHHHHHCCCHHHH		24275569
679	Phosphorylation	RSVRSRLYVGREKKL HHHHHHHCCCHHHHH		24719451
705	Phosphorylation	SKLLEKFSLVQKEYE HHHHHHHCHHHHHHC		29396449
711	Phosphorylation	FSLVQKEYEGYEVES HCHHHHHHCCCCCCC		28796482
714	Phosphorylation	VQKEYEGYEVESSLK HHHHHCCCCCCCHHC		28796482
718	Phosphorylation	YEGYEVESSLKDASF HCCCCCCCHHCCCCC		30108239
719	Phosphorylation	EGYEVESSLKDASFE CCCCCCCHHCCCCCH		30108239
724	Phosphorylation	ESSLKDASFEKEATE CCHHCCCCCHHHHHH		23663014
730	Phosphorylation	ASFEKEATEAQSLEA CCCHHHHHHHHHHHH		23663014
734	Phosphorylation	KEATEAQSLEATCEK HHHHHHHHHHHHHHH		21815630
745	Phosphorylation	TCEKLNRSNSELEDE HHHHHHHCCCHHHHH		25159151
747	Phosphorylation	EKLNRSNSELEDEIL HHHHHCCCHHHHHHH		25159151
783	Phosphorylation	DISKRIQSLEDESKS HHHHHHHHHHHHHHH		21815630
788	Phosphorylation	IQSLEDESKSLKSQV HHHHHHHHHHHHHHH		23312004
790	Phosphorylation	SLEDESKSLKSQVAE HHHHHHHHHHHHHHH		23312004
857	Phosphorylation	QKVTFEDSKVHAEQV CCCEECCCHHCHHHH		22468782
1009	Phosphorylation	MKLHRKLTVEENYRL HHHHHHCCHHHHHHH		27273156
1014	Phosphorylation	KLTVEENYRLEKEEK HCCHHHHHHHHHHHH		-
1038	Phosphorylation	HATEELETYRKRAKD HHHHHHHHHHHHHHH		-
1039	Phosphorylation	ATEELETYRKRAKDL HHHHHHHHHHHHHHH		-
1063	Phosphorylation	SYQGQIISHEKKAHD HHHHCEECCCHHHHH		28555341
1111	Phosphorylation	ELLEKDPYALDVPNT HHHHCCCCCCCCCCC		29978859
1118	Phosphorylation	YALDVPNTAFGREHS CCCCCCCCCCCCCCC		27273156
1125	Phosphorylation	TAFGREHSPYGPSPL CCCCCCCCCCCCCCC		23401153
1127	Phosphorylation	FGREHSPYGPSPLGW CCCCCCCCCCCCCCC		23927012
1130	Phosphorylation	EHSPYGPSPLGWPSS CCCCCCCCCCCCCCH		25159151
1136	Phosphorylation	PSPLGWPSSETRAFL CCCCCCCCHHHCCCC		23403867
1137	Phosphorylation	SPLGWPSSETRAFLS CCCCCCCHHHCCCCC		23403867
1139	Phosphorylation	LGWPSSETRAFLSPP CCCCCHHHCCCCCCC		23090842
1144	Phosphorylation	SETRAFLSPPTLLEG HHHCCCCCCCCCCCC		29255136
1147	Phosphorylation	RAFLSPPTLLEGPLR CCCCCCCCCCCCCCC		30266825
1156	Phosphorylation	LEGPLRLSPLLPGGG CCCCCCCCCCCCCCC		29255136
1167	Phosphorylation	PGGGGRGSRGPGNPL CCCCCCCCCCCCCCC		29255136
1179	Phosphorylation	NPLDHQITNERGESS CCCCHHCCCCCCCCC		23312004
1185	Phosphorylation	ITNERGESSCDRLTD CCCCCCCCCCCCCCC		25850435
1186	Phosphorylation	TNERGESSCDRLTDP CCCCCCCCCCCCCCC		25850435
1191	Phosphorylation	ESSCDRLTDPHRAPS CCCCCCCCCCCCCCC		23927012
1198	Phosphorylation	TDPHRAPSDTGSLSP CCCCCCCCCCCCCCC		30266825
1200	Phosphorylation	PHRAPSDTGSLSPPW CCCCCCCCCCCCCCC		30266825
1202	Phosphorylation	RAPSDTGSLSPPWDQ CCCCCCCCCCCCCCC		23927012
1204	Phosphorylation	PSDTGSLSPPWDQDR CCCCCCCCCCCCCCC		23927012
1221	Phosphorylation	MFPPPGQSYPDSALP CCCCCCCCCCCCCCC		24275569
1222	Phosphorylation	FPPPGQSYPDSALPP CCCCCCCCCCCCCCC		24275569
1237	Phosphorylation	QRQDRFCSNSGRLSG HHCCCCCCCCCCCCC		23927012
1239	Phosphorylation	QDRFCSNSGRLSGPA CCCCCCCCCCCCCCH		23927012
1243	Phosphorylation	CSNSGRLSGPAELRS CCCCCCCCCCHHHHH		29255136
1250	Phosphorylation	SGPAELRSFNMPSLD CCCHHHHHCCCCCHH		23927012
1255	Phosphorylation	LRSFNMPSLDKMDGS HHHCCCCCHHCCCCC		23927012
1262	Phosphorylation	SLDKMDGSMPSEMES CHHCCCCCCCHHHHH		23401153
1265	Phosphorylation	KMDGSMPSEMESSRN CCCCCCCHHHHHCCC		29083192
1269	Phosphorylation	SMPSEMESSRNDTKD CCCHHHHHCCCCCCC		30576142
1270	Phosphorylation	MPSEMESSRNDTKDD CCHHHHHCCCCCCCC		22115753
1274	Phosphorylation	MESSRNDTKDDLGNL HHHCCCCCCCCCCCC		22115753
1286	Phosphorylation	GNLNVPDSSLPAENE CCCCCCCCCCCCCCC		24275569

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MIA2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MIA2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MIA2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of MIA2_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.