EPG5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EPG5_HUMAN
• UniProt AC: Q9HCE0
• Protein Name: Ectopic P granules protein 5 homolog
• Gene Name: EPG5
• Organism: Homo sapiens (Human).
• Sequence Length: 2579
• Protein Description: Involved in autophagy. May play a role in a late step of autophagy, such as clearance of autophagosomal cargo..
• Protein Sequence: MAEAVKPQRRAKAKASRTKTKEKKKYETPQREESSEVSLPKTSREQEIPSLACEFKGDHLKVVTDSQLQDDASGQNESEMFDVPLTSLTISNEESLTCNTEPPKEGGEARPCVGDSAVTPKVHPGDNVGTKVETPKNFTEVEENMSVQGGLSESAPQSNFSYTQPAMENIQVRETQNSKEDKQGLVCSSEVPQNVGLQSSCPAKHGFQTPRVKKLYPQLPAEIAGEAPALVAVKPLLRSERLYPELPSQLELVPFTKEQLKILEPGSWLENVESYLEEFDSMAHQDRHEFYELLLNYSRCRKQLLLAEAELLTLTSDCQNAKSRLWQFKEEQMSVQGICADQVKVFSYHRYQRVEMNENALVELKKLFDAKSEHLHQTLALHSYTSVLSRLQVESYIYALLSSSAVLRSSAIHQQGRASKQTESIPSDLCQLKECISVLFMFTRRVNEDTQFHDDILLWLQKLVSVLQRVGCPGDHLFLLNHILRCPAGVSKWAVPFIQIKVLHNPSGVFHFMQSLALLMSPVKNRAEFMCHMKPSERKPSSSGPGSGTWTLVDEGGEEDEDPETSWILLNEDDLVTILAQFPFHELFQHLLGFKAKGDYLPETTRPQEMMKIFAFANSLVELLAVGLETFNRARYRQFVKRIGYMIRMTLGYVSDHWAQYVSHNQGSGLAQQPYSMEKLQVEFDELFLRAVLHVLKAKRLGIWLFMSEMPFGTLSVQMLWKLFYLMHQVESENLQQLSSSLQPAQCKQQLQDPEHFTNFEKCLSSMNSSEEICLLTTFAQMAQARRTNVDEDFIKIIVLEIYEVSYVTLSTRETFSKVGRELLGTITAVHPEIISVLLDRVQETIDQVGMVSLYLFKELPLYLWQPSASEIAVIRDWLLNYNLTVVKNKLACVILEGLNWGFAKQATLHLDQAVHAEVALMVLEAYQKYLAQKPYAGILSESMKQVSYLASIVRYGETPETSFNQWAWNLILRLKLHKNDYGIQPNCPAVPFSVTVPDMTESPTFHPLLKAVKAGMPIGCYLALSMTAVGHSIEKFCAEGIPLLGILVQSRHLRTVVHVLDKILPLFYPCQYYLLKNEQFLSHLLLFLHLDSGVPQGVTQQVTHKVAQHLTGASHGDNVKLLNSMIQAHISVSTQPNEVGPVAVLEFWVQALISQHLWYREQPILFLMDHLCKAAFQLMQEDCIQKLLYQQHKNALGYHCDRSLLSSLVSWIVAGNITPSFVEGLATPTQVWFAWTVLNMESIFEEDSQLRRVIEGELVINSAFTPDQALKKAQTQLKLPIVPSLQRLLIYRWAHQALVTPSDHPLLPLIWQKFFLLYLHRPGPQYGLPIDGCIGRRFFQSPAHINLLKEMKRRLTEVADFHHAASKALRVPAEGSEGLPESHSGTPGYLTSPELHKELVRLFNVYILWLEDENFQKGDTYIPSLPKHYDIHRLAKVMQNQQDLWMEYLNMERIYHEFQETVGLWTQAKLESHSTPCSLSVQLDFTDPLLAKERVLSNLRKHEAPQPPLALHPTKPPVPVISSAVLLSQKDATQLVCTDLNLLQQQARTAALRESQQVALDGELLDTMPKQYVNREEQTTLHLECRGSSGKKCQGAAVVTVQFEGMHKNEAISQQLHVLRKEVKQLQAEAAKPPSLNIVEAAVHAENLITALVNAYKLQPTPGIQKVGISLFFTIVDYVSDETQRHPPTRQFFTSCIEILGQVFISGIKSECRKVLETILKNSRLCSLLSPFFTPNAAPAEFIQLYEQVVKFLSEDNSDMIFMLLTKFDLKQWLSATKPPLSDRTRLLESIHLALTAWGLEPDEDILMPFNLFCKHWTYLLLYQFPDQYSDILRLLMQSSAEQLLSPECWKATLRALGCCAPSCQQGAASTEGAVLPSSSDALLSDKQVMETIQWLSDFFYKLRLSKMDFKSFGLFSKWSPYMADVKTFLGYLVKRLIDLEMTCLAQDPTASRKTVLKSLHSVIIQLFKPWILVLEDNESSQQRHYPWLESDTVVASSIVQLFTDCIDSLHESFKDKLLPGDAGALWLHLMHYCEACTAPKMPEFILYAFHSTYRKLPWKDLHPDQMLMEAFFKVERGSPKSCFLFLGSVLCEVNWVSVLSDAWNSSPHPETRSMIVCLLFMMILLAKEVQLVDQTDSPLLSLLGQTSSLSWHLVDIVSYQSVLSYFSSHYPPSIILAKESYAELIMKLLKVSAGLSIPTDSQKHLDAVPKCQAFTHQMVQFLSTLEQNGKITLAVLEQEMSKLLDDIIVFNPPDMDSQTRHMALSSLFMEVLMMMNNATIPTAEFLRGSIRTWIGQKMHGLVVLPLLTAACQSLASVRHMAETTEACITAYFKESPLNQNSGWGPILVSLQVPELTMEEFLQECLTLGSYLTLYVYLLQCLNSEQTLRNEMKVLLILSKWLEQVYPSSVEEEAKLFLWWHQVLQLSLIQTEQNDSVLTESVIRILLLVQSRQNLVAEERLSSGILGAIGFGRKSPLSNRFRVVARSMAAFLSVQVPMEDQIRLRPGSELHLTPKAQQALNALESMASSKQYVEYQDQILQATQFIRHPGHCLQDGKSFLALLVNCLYPEVHYLDHIR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Phosphorylation	RRAKAKASRTKTKEK HHHHHHHHCCCCHHH	39.51	29457462
28	Phosphorylation	KEKKKYETPQREESS HHHHHCCCCCCHHCC	22.95	25159151
34	Phosphorylation	ETPQREESSEVSLPK CCCCCHHCCCCCCCC	27.35	28348404
35	Phosphorylation	TPQREESSEVSLPKT CCCCHHCCCCCCCCC	45.34	28348404
119	Phosphorylation	CVGDSAVTPKVHPGD CCCCCCCCCCCCCCC	19.67	25159151
130	Phosphorylation	HPGDNVGTKVETPKN CCCCCCCCEECCCCC	27.86	23186163
134	Phosphorylation	NVGTKVETPKNFTEV CCCCEECCCCCCCCC	42.42	10997877
188	Phosphorylation	DKQGLVCSSEVPQNV CCCCEEECCCCCCCC	23.27	25850435
189	Phosphorylation	KQGLVCSSEVPQNVG CCCEEECCCCCCCCC	37.17	25850435
234	Ubiquitination	APALVAVKPLLRSER CCHHHHHHHHHCCCC	21.88	-
248	Phosphorylation	RLYPELPSQLELVPF CCCCCCCCCCEEEEC	61.08	20071362
257	Ubiquitination	LELVPFTKEQLKILE CEEEECCHHHHHHCC	43.79	-
261	Ubiquitination	PFTKEQLKILEPGSW ECCHHHHHHCCCCCH	44.96	-
297	Phosphorylation	FYELLLNYSRCRKQL HHHHHHHHHHHHHHH	9.47	18767875
298	Phosphorylation	YELLLNYSRCRKQLL HHHHHHHHHHHHHHH	24.67	18767875
329	Ubiquitination	KSRLWQFKEEQMSVQ HHHHHHCHHHHHCCC	45.28	-
396	Phosphorylation	SRLQVESYIYALLSS HHHHHHHHHHHHHCC	5.62	22210691
402	Phosphorylation	SYIYALLSSSAVLRS HHHHHHHCCCHHHHH	24.09	22210691
409	Phosphorylation	SSSAVLRSSAIHQQG CCCHHHHHHHHHHCC	21.69	-
410	Phosphorylation	SSAVLRSSAIHQQGR CCHHHHHHHHHHCCC	25.47	-
419	Phosphorylation	IHQQGRASKQTESIP HHHCCCCCCCCCCCC	24.76	22210691
422	Phosphorylation	QGRASKQTESIPSDL CCCCCCCCCCCCHHH	35.12	-
492	Acetylation	RCPAGVSKWAVPFIQ HCCCCCCCCCCCEEE	36.44	12433943
507	Phosphorylation	IKVLHNPSGVFHFMQ EEECCCCCHHHHHHH	53.56	-
521	Phosphorylation	QSLALLMSPVKNRAE HHHHHHHCCCCCCHH	26.89	-
597	Malonylation	HLLGFKAKGDYLPET HHHCCCCCCCCCCCC	53.56	32601280
708	Phosphorylation	LGIWLFMSEMPFGTL CCEEEEECCCCCCCH	24.33	23401153
714	Phosphorylation	MSEMPFGTLSVQMLW ECCCCCCCHHHHHHH	19.08	23401153
716	Phosphorylation	EMPFGTLSVQMLWKL CCCCCCHHHHHHHHH	15.33	23401153
811	Phosphorylation	EVSYVTLSTRETFSK EEEEEEECCHHHHHH	18.95	24719451
818	Ubiquitination	STRETFSKVGRELLG CCHHHHHHHHHHHHH	44.51	-
826	Phosphorylation	VGRELLGTITAVHPE HHHHHHHHHHHCCHH	18.34	-
828	Phosphorylation	RELLGTITAVHPEII HHHHHHHHHCCHHHH	23.59	-
934	Ubiquitination	YQKYLAQKPYAGILS HHHHHCCCCCCCCCC	34.10	-
936	Phosphorylation	KYLAQKPYAGILSES HHHCCCCCCCCCCHH	25.21	27642862
1056	Phosphorylation	VQSRHLRTVVHVLDK HHCCCHHHHHHHHHH	32.99	23898821
1279	Ubiquitination	KKAQTQLKLPIVPSL HHHHHHCCCCCCHHH	42.26	-
1285	Phosphorylation	LKLPIVPSLQRLLIY CCCCCCHHHHHHHHH	26.66	26091039
1350	Ubiquitination	PAHINLLKEMKRRLT HHHHHHHHHHHHHHH	59.95	-
1357	Phosphorylation	KEMKRRLTEVADFHH HHHHHHHHHHHHHHH	26.97	22210691
1368 (in isoform 2)	Ubiquitination	-	46.87	21890473
1368 (in isoform 1)	Ubiquitination	-	46.87	21890473
1368	Ubiquitination	DFHHAASKALRVPAE HHHHHHHHHHCCCCC	46.87	21890473
1368	Malonylation	DFHHAASKALRVPAE HHHHHHHHHHCCCCC	46.87	26320211
1377	Phosphorylation	LRVPAEGSEGLPESH HCCCCCCCCCCCCCC	21.72	23312004
1383	Phosphorylation	GSEGLPESHSGTPGY CCCCCCCCCCCCCCC	22.48	28450419
1385	Phosphorylation	EGLPESHSGTPGYLT CCCCCCCCCCCCCCC	54.35	28450419
1387	Phosphorylation	LPESHSGTPGYLTSP CCCCCCCCCCCCCCH	19.29	28450419
1390	Phosphorylation	SHSGTPGYLTSPELH CCCCCCCCCCCHHHH	14.17	28270605
1392	Phosphorylation	SGTPGYLTSPELHKE CCCCCCCCCHHHHHH	33.48	28450419
1393	Phosphorylation	GTPGYLTSPELHKEL CCCCCCCCHHHHHHH	17.49	28450419
1428	Ubiquitination	TYIPSLPKHYDIHRL CCCCCCCCCCCHHHH	61.15	-
1493	Ubiquitination	FTDPLLAKERVLSNL CCCHHHHHHHHHHHH	46.12	-
1498	Phosphorylation	LAKERVLSNLRKHEA HHHHHHHHHHHHCCC	30.84	24719451
1556	Phosphorylation	RTAALRESQQVALDG HHHHHHHHHHHHHCC	21.34	-
1580	Phosphorylation	YVNREEQTTLHLECR HCCHHHCEEEEEEEE	34.31	28348404
1581	Phosphorylation	VNREEQTTLHLECRG CCHHHCEEEEEEEEC	16.33	28348404
1589	Phosphorylation	LHLECRGSSGKKCQG EEEEEECCCCCCCCC	19.30	24719451
1590	Phosphorylation	HLECRGSSGKKCQGA EEEEECCCCCCCCCE	58.41	28348404
1907	Phosphorylation	FFYKLRLSKMDFKSF HHHHHHHCCCCHHHC	21.35	24702127
1918	Phosphorylation	FKSFGLFSKWSPYMA HHHCCCCCCCCCHHH	37.95	24719451
1933	Phosphorylation	DVKTFLGYLVKRLID HHHHHHHHHHHHHHH	15.52	29759185
2049	Phosphorylation	KMPEFILYAFHSTYR CCCHHHHHHHHHHCC	11.47	22210691
2053	Phosphorylation	FILYAFHSTYRKLPW HHHHHHHHHCCCCCH	22.23	22210691
2054	Phosphorylation	ILYAFHSTYRKLPWK HHHHHHHHCCCCCHH	20.83	22210691
2205	Ubiquitination	SIPTDSQKHLDAVPK CCCCCCHHHHCCCCH	50.52	-
2315	Phosphorylation	LLTAACQSLASVRHM HHHHHHHHHHHHHHH	26.28	-
2318	Phosphorylation	AACQSLASVRHMAET HHHHHHHHHHHHHHH	25.61	-
2400	Phosphorylation	MKVLLILSKWLEQVY HHHHHHHHHHHHHHC	18.13	27307780
2494	Phosphorylation	RSMAAFLSVQVPMED HHHHHHHCCCCCCHH	12.21	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EPG5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EPG5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EPG5_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of EPG5_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 242840: Vici syndrome (VICIS)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.