KLRF1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KLRF1_HUMAN
• UniProt AC: Q9NZS2
• Protein Name: Killer cell lectin-like receptor subfamily F member 1
• Gene Name: KLRF1
• Organism: Homo sapiens (Human).
• Sequence Length: 232
• Subcellular Localization: Membrane ; Single-pass type II membrane protein .
• Protein Description: Involved in the natural killer (NK)-mediated cytolysis of PHA-induced lymphoblasts..
• Protein Sequence: MQDEERYMTLNVQSKKRSSAQTSQLTFKDYSVTLHWYKILLGISGTVNGILTLTLISLILLVSQGVLLKCQKGSCSNATQYEDTGDLKVNNGTRRNISNKDLCASRSADQTVLCQSEWLKYQGKCCYWFSNEMKSWSDSYVYCLERKSHLLIIHDQLEMAFIQKNLRQLNYVWIGLNFTSLKMTWTWVDGSPIDSKIFFIKGPAKENSCAAIKESKIFSETCSSVFKWICQY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MQDEERYMTLNVQS -CCCHHHHEEEECCC	9.57	21149606
18	Phosphorylation	NVQSKKRSSAQTSQL ECCCCCCCCCCCEEC	38.62	29978859
19	Phosphorylation	VQSKKRSSAQTSQLT CCCCCCCCCCCEECE	28.56	29978859
22	Phosphorylation	KKRSSAQTSQLTFKD CCCCCCCCEECEECC	20.39	29978859
23	Phosphorylation	KRSSAQTSQLTFKDY CCCCCCCEECEECCH	15.88	29978859
26	Phosphorylation	SAQTSQLTFKDYSVT CCCCEECEECCHHEE	22.47	29978859
33	Phosphorylation	TFKDYSVTLHWYKIL EECCHHEEEEHHHHH	13.63	29759185
37	Phosphorylation	YSVTLHWYKILLGIS HHEEEEHHHHHHCCC	4.20	29759185
77	N-linked_Glycosylation	CQKGSCSNATQYEDT CCCCCCCCCCCCCCC	51.86	UniProtKB CARBOHYD
91	N-linked_Glycosylation	TGDLKVNNGTRRNIS CCCEEECCCCCCCCC	57.09	UniProtKB CARBOHYD
96	N-linked_Glycosylation	VNNGTRRNISNKDLC ECCCCCCCCCCCCCC	38.46	UniProtKB CARBOHYD
176	N-linked_Glycosylation	LNYVWIGLNFTSLKM CCEEEEEECCCEEEE	3.33	-
177	N-linked_Glycosylation	NYVWIGLNFTSLKMT CEEEEEECCCEEEEE	32.70	UniProtKB CARBOHYD
184	Phosphorylation	NFTSLKMTWTWVDGS CCCEEEEEEEEECCC	20.39	-
219	Phosphorylation	IKESKIFSETCSSVF HHHCHHHHHHHHHHH	35.15	26471730

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KLRF1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KLRF1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KLRF1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
G3PT_HUMAN	GAPDHS	physical	26186194
TOM40_HUMAN	TOMM40	physical	26186194
REEP5_HUMAN	REEP5	physical	26186194
CBWD1_HUMAN	CBWD1	physical	26186194
REEP6_HUMAN	REEP6	physical	26186194
REEP6_HUMAN	REEP6	physical	28514442
G3PT_HUMAN	GAPDHS	physical	28514442
TOM40_HUMAN	TOMM40	physical	28514442
REEP5_HUMAN	REEP5	physical	28514442
CBWD1_HUMAN	CBWD1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.