CP20A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CP20A_HUMAN
• UniProt AC: Q6UW02
• Protein Name: Cytochrome P450 20A1
• Gene Name: CYP20A1
• Organism: Homo sapiens (Human).
• Sequence Length: 462
• Subcellular Localization: Membrane ; Single-pass membrane protein .
• Protein Sequence: MLDFAIFAVTFLLALVGAVLYLYPASRQAAGIPGITPTEEKDGNLPDIVNSGSLHEFLVNLHERYGPVVSFWFGRRLVVSLGTVDVLKQHINPNKTSDPFETMLKSLLRYQSGGGSVSENHMRKKLYENGVTDSLKSNFALLLKLSEELLDKWLSYPETQHVPLSQHMLGFAMKSVTQMVMGSTFEDDQEVIRFQKNHGTVWSEIGKGFLDGSLDKNMTRKKQYEDALMQLESVLRNIIKERKGRNFSQHIFIDSLVQGNLNDQQILEDSMIFSLASCIITAKLCTWAICFLTTSEEVQKKLYEEINQVFGNGPVTPEKIEQLRYCQHVLCETVRTAKLTPVSAQLQDIEGKIDRFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRFDDELVMKTFSSLGFSGTQECPELRFAYMVTTVLLSVLVKRLHLLSVEGQVIETKYELVTSSREEAWITVSKRY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
80	Phosphorylation	FGRRLVVSLGTVDVL CCCEEEEEECHHHHH	17.38	23612710
83	Phosphorylation	RLVVSLGTVDVLKQH EEEEEECHHHHHHHH	20.87	23612710
106	Phosphorylation	PFETMLKSLLRYQSG HHHHHHHHHHHHHCC	28.77	24719451
132	Phosphorylation	KLYENGVTDSLKSNF HHHHCCCCHHHHHHH	22.67	-
137	Phosphorylation	GVTDSLKSNFALLLK CCCHHHHHHHHHHHH	42.34	23898821
146	Phosphorylation	FALLLKLSEELLDKW HHHHHHHCHHHHHHH	27.69	23898821
224	Phosphorylation	NMTRKKQYEDALMQL CCCCHHHHHHHHHHH	25.34	-
233	Phosphorylation	DALMQLESVLRNIIK HHHHHHHHHHHHHHH	34.74	-
316	Phosphorylation	VFGNGPVTPEKIEQL HHCCCCCCHHHHHHH	28.94	25159151
338	Ubiquitination	CETVRTAKLTPVSAQ HHHHHHCCCCCCCHH	52.89	29967540
340	Phosphorylation	TVRTAKLTPVSAQLQ HHHHCCCCCCCHHHH	22.42	29396449
343	Phosphorylation	TAKLTPVSAQLQDIE HCCCCCCCHHHHHCC	16.11	29396449
404	Phosphorylation	TFSSLGFSGTQECPE HHHHCCCCCCCCCCH	38.85	22210691
419	Phosphorylation	LRFAYMVTTVLLSVL HHHHHHHHHHHHHHH	8.48	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CP20A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CP20A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CP20A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
PIEZ1_HUMAN	PIEZO1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.