dbPTM

IL1A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	IL1A_HUMAN
UniProt AC	P01583
Protein Name	Interleukin-1 alpha
Gene Name	IL1A
Organism	Homo sapiens (Human).
Sequence Length	271
Subcellular Localization	Secreted. The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.
Protein Description	Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells..
Protein Sequence	MAKVPDMFEDLKNCYSENEEDSSSIDHLSLNQKSFYHVSYGPLHEGCMDQSVSLSISETSKTSKLTFKESMVVVATNGKVLKKRRLSLSQSITDDDLEAIANDSEEEIIKPRSAPFSFLSNVKYNFMRIIKYEFILNDALNQSIIRANDQYLTAAALHNLDEAVKFDMGAYKSSKDDAKITVILRISKTQLYVTAQDEDQPVLLKEMPEIPKTITGSETNLLFFWETHGTKNYFTSVAHPNLFIATKQDYWVCLAGGPPSITDFQILENQA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	FEDLKNCYSENEEDS HHHHHHHCCCCCCCC	28.54	25002506
16	Phosphorylation	EDLKNCYSENEEDSS HHHHHHCCCCCCCCC	35.82	30108239
22	Phosphorylation	YSENEEDSSSIDHLS CCCCCCCCCCCCEEE	29.30	30108239
23	Phosphorylation	SENEEDSSSIDHLSL CCCCCCCCCCCEEEE	43.57	30108239
24	Phosphorylation	ENEEDSSSIDHLSLN CCCCCCCCCCEEEEC	35.67	27794612
29	Phosphorylation	SSSIDHLSLNQKSFY CCCCCEEEECCCCEE	23.12	25002506
59	Phosphorylation	VSLSISETSKTSKLT EEEEEECCCCCCCCC	28.82	-
60	Phosphorylation	SLSISETSKTSKLTF EEEEECCCCCCCCCC	29.86	-
66	Phosphorylation	TSKTSKLTFKESMVV CCCCCCCCCCCCEEE	36.08	-
82	N6-myristoyl lysine	ATNGKVLKKRRLSLS EECCCEEEEECCCCC	47.42	-
82	Myristoylation	ATNGKVLKKRRLSLS EECCCEEEEECCCCC	47.42	8346241
83	Myristoylation	TNGKVLKKRRLSLSQ ECCCEEEEECCCCCC	38.29	8346241
83	N6-myristoyl lysine	TNGKVLKKRRLSLSQ ECCCEEEEECCCCCC	38.29	-
87	Phosphorylation	VLKKRRLSLSQSITD EEEEECCCCCCCCCH	24.94	28355574
89	Phosphorylation	KKRRLSLSQSITDDD EEECCCCCCCCCHHH	20.64	28176443
91	Phosphorylation	RRLSLSQSITDDDLE ECCCCCCCCCHHHHH	24.87	28176443
93	Phosphorylation	LSLSQSITDDDLEAI CCCCCCCCHHHHHHH	38.33	29507054
102	N-linked_Glycosylation	DDLEAIANDSEEEII HHHHHHHCCCHHHCC	47.42	UniProtKB CARBOHYD
104	Phosphorylation	LEAIANDSEEEIIKP HHHHHCCCHHHCCCC	46.87	26657352
141	N-linked_Glycosylation	FILNDALNQSIIRAN HHHCHHHHHHHHHHC	34.96	UniProtKB CARBOHYD
143	Phosphorylation	LNDALNQSIIRANDQ HCHHHHHHHHHHCCH	20.93	24719451
189	Phosphorylation	VILRISKTQLYVTAQ EEEEECCCEEEEEEC	19.60	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of IL1A_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of IL1A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of IL1A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NECD_HUMAN	NDN	physical	12913118
S10AD_HUMAN	S100A13	physical	12746488
HAX1_HUMAN	HAX1	physical	11554782
IL1A_HUMAN	IL1A	physical	11554782
SPT7_YEAST	SPT7	physical	22879895
SPT8_YEAST	SPT8	physical	22879895
HFI1_YEAST	HFI1	physical	22879895
GCN5_YEAST	GCN5	physical	22879895
ADA2_YEAST	ADA2	physical	22879895
NGG1_YEAST	NGG1	physical	22879895
AHC1_YEAST	AHC1	physical	22879895
IL1R2_HUMAN	IL1R2	physical	25241761

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of IL1A_HUMAN

Related Literatures of Post-Translational Modification

Myristoylation
Reference	PubMed
"The 31-kDa precursor of interleukin 1 alpha is myristoylated onspecific lysines within the 16-kDa N-terminal propiece."; Stevenson F.T., Bursten S.L., Fanton C., Locksley R.M., Lovett D.H.; Proc. Natl. Acad. Sci. U.S.A. 90:7245-7249(1993). Cited for: MYRISTOYLATION AT LYS-82 AND LYS-83.	8346241 [Abstract]