SAMD7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SAMD7_HUMAN
• UniProt AC: Q7Z3H4
• Protein Name: Sterile alpha motif domain-containing protein 7
• Gene Name: SAMD7
• Organism: Homo sapiens (Human).
• Sequence Length: 446
• Subcellular Localization: Nucleus . Cytoplasm .
• Protein Description: Involved in the regulation of gene expression in the retina. It functions as a negative regulator of CRX-controlled genes..
• Protein Sequence: MAVNPLLTPTGQQTIPLIPSPFGPPTVDRDVLPSTVAPTDPRQFCVPSQFGSSVLPNTNMANVLSSRIYPGWGILPPESIKAVARRNEMIQRHHTARTEMEMYAIYQQRRMEKINPKGLAGLGIPFLYGSSVPAAPAAYHGRSMLPAGDLHFHRSTLRNLQGNPMLAATAPHFEESWGQRCRRLRKNTGNQKALDSDAESSKSQAEEKILGQTHAVPYEEDHYAKDPDIEAPSNQKSSETNEKPTTALANTCGELEPTHRKPWGSHTTTLKAKAWDDGKEEASEQIFATCDEKNGVCPPVPRPSLPGTHALVTIGGNLSLDEDIQKWTVDDVHSFIRSLPGCSDYAQVFKDHAIDGETLPLLTEEHLRGTMGLKLGPALKIQSQVSQHVGSMFYKKTLSFPIRQAFDQPADTSPLLDPNSWSDTMNIFCPQDTIIPKGIERGSMRN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MAVNPLLTPTGQQTI CCCCCCCCCCCCCCC	26.87	24043423
10	Phosphorylation	VNPLLTPTGQQTIPL CCCCCCCCCCCCCCC	42.24	24043423
14	Phosphorylation	LTPTGQQTIPLIPSP CCCCCCCCCCCCCCC	19.37	24043423
20	Phosphorylation	QTIPLIPSPFGPPTV CCCCCCCCCCCCCCC	26.35	24043423
26	Phosphorylation	PSPFGPPTVDRDVLP CCCCCCCCCCCCCCC	37.87	24043423
48	Phosphorylation	PRQFCVPSQFGSSVL HHCCCCCCCCCCCCC	20.11	24043423
52	Phosphorylation	CVPSQFGSSVLPNTN CCCCCCCCCCCCCCC	20.68	24043423
53	Phosphorylation	VPSQFGSSVLPNTNM CCCCCCCCCCCCCCH	28.22	24043423
58	Phosphorylation	GSSVLPNTNMANVLS CCCCCCCCCHHHHHH	25.16	24043423
65	Phosphorylation	TNMANVLSSRIYPGW CCHHHHHHCCCCCCC	17.18	24043423
66	Phosphorylation	NMANVLSSRIYPGWG CHHHHHHCCCCCCCC	20.66	24719451
155	Phosphorylation	GDLHFHRSTLRNLQG CCCEECHHHHHHHCC	24.19	27174698
156	Phosphorylation	DLHFHRSTLRNLQGN CCEECHHHHHHHCCC	29.69	27174698
338	Phosphorylation	DVHSFIRSLPGCSDY HHHHHHHCCCCCCHH	33.81	-
391	Phosphorylation	QVSQHVGSMFYKKTL HHHHHHHHHHHHHEC	12.48	22817900
394	Phosphorylation	QHVGSMFYKKTLSFP HHHHHHHHHHECCCC	11.70	25884760

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SAMD7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SAMD7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SAMD7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
G3PT_HUMAN	GAPDHS	physical	26186194
SON_HUMAN	SON	physical	26186194
KLH15_HUMAN	KLHL15	physical	26186194
SAM11_HUMAN	SAMD11	physical	26186194
SAM11_HUMAN	SAMD11	physical	28514442
G3PT_HUMAN	GAPDHS	physical	28514442
F16P1_HUMAN	FBP1	physical	28514442
KLH15_HUMAN	KLHL15	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.