T200A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: T200A_HUMAN
• UniProt AC: Q86VY9
• Protein Name: Transmembrane protein 200A
• Gene Name: TMEM200A
• Organism: Homo sapiens (Human).
• Sequence Length: 491
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Sequence: MIATGGVITGLAALKRQDSARSQQHVNLSPSPATQEKKPIRRRPRADVVVVRGKIRLYSPSGFFLILGVLISIIGIAMAVLGYWPQKEHFIDAETTLSTNETQVIRNEGGVVVRFFEQHLHSDKMKMLGPFTMGIGIFIFICANAILHENRDKETKIIHMRDIYSTVIDIHTLRIKEQRQMNGMYTGLMGETEVKQNGSSCASRLAANTIASFSGFRSSFRMDSSVEEDELMLNEGKSSGHLMPPLLSDSSVSVFGLYPPPSKTTDDKTSGSKKCETKSIVSSSISAFTLPVIKLNNCVIDEPSIDNITEDADNLKSRSRNLSMDSLVVPLPNTSESFQPVSTVLPRNNSIGESLSSQYKSSMALGPGAGQLLSPGAARRQFGSNTSLHLLSSHSKSLDLDRGPSTLTVQAEQRKHPSWPRLDRNNSKGYMKLENKEDPMDRLLVPQVAIKKDFTNKEKLLMISRSHNNLSFEHDEFLSNNLKRGTSETRF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MIATGGVITGL ----CCCCCCHHHHH	24.44	29396449
9	Phosphorylation	IATGGVITGLAALKR CCCCCHHHHHHHHHH	24.60	29396449
19	Phosphorylation	AALKRQDSARSQQHV HHHHHCCCHHHHCCC	19.76	29496963
22	Phosphorylation	KRQDSARSQQHVNLS HHCCCHHHHCCCCCC	33.63	30266825
29	Phosphorylation	SQQHVNLSPSPATQE HHCCCCCCCCCCCCC	20.37	30266825
31	Phosphorylation	QHVNLSPSPATQEKK CCCCCCCCCCCCCCC	24.64	30266825
34	Phosphorylation	NLSPSPATQEKKPIR CCCCCCCCCCCCCCC	40.42	29514088
72	Phosphorylation	LILGVLISIIGIAMA HHHHHHHHHHHHHHH	12.18	22210691
100	N-linked_Glycosylation	AETTLSTNETQVIRN CCCCCCCCCCEEEEC	47.12	UniProtKB CARBOHYD
164	Phosphorylation	IIHMRDIYSTVIDIH EEEHHHHHHHHEEEE	11.54	28152594
165	Phosphorylation	IHMRDIYSTVIDIHT EEHHHHHHHHEEEEH	19.28	28152594
166	Phosphorylation	HMRDIYSTVIDIHTL EHHHHHHHHEEEEHH	12.43	23312004
172	Phosphorylation	STVIDIHTLRIKEQR HHHEEEEHHHHHHHH	20.33	27050516
185	Phosphorylation	QRQMNGMYTGLMGET HHHHCCCCCCCCCCC	10.07	24961811
186	Phosphorylation	RQMNGMYTGLMGETE HHHCCCCCCCCCCCC	18.23	24961811
192	Phosphorylation	YTGLMGETEVKQNGS CCCCCCCCCHHHCCC	40.11	25002506
212	Phosphorylation	LAANTIASFSGFRSS HHHHHHHHHCCCHHH	18.98	28857561
214	Phosphorylation	ANTIASFSGFRSSFR HHHHHHHCCCHHHCC	34.23	24719451
218	Phosphorylation	ASFSGFRSSFRMDSS HHHCCCHHHCCCCCC	31.41	29514088
219	Phosphorylation	SFSGFRSSFRMDSSV HHCCCHHHCCCCCCC	16.77	29514088
224	Phosphorylation	RSSFRMDSSVEEDEL HHHCCCCCCCCHHHH	27.26	29514088
225	Phosphorylation	SSFRMDSSVEEDELM HHCCCCCCCCHHHHH	29.32	28985074
253	Phosphorylation	LLSDSSVSVFGLYPP CCCCCCEEEEEECCC	17.42	-
279	Phosphorylation	SKKCETKSIVSSSIS CCCCCCHHHHCCCCC	35.33	27050516
284	Phosphorylation	TKSIVSSSISAFTLP CHHHHCCCCCEECCC	17.04	30257219
304	Phosphorylation	NCVIDEPSIDNITED CCEECCCCCCCCCCC	40.29	29514088
309	Phosphorylation	EPSIDNITEDADNLK CCCCCCCCCCHHHHH	33.78	29514088
319	Phosphorylation	ADNLKSRSRNLSMDS HHHHHHHCCCCCCCE	32.39	-
323	Phosphorylation	KSRSRNLSMDSLVVP HHHCCCCCCCEEEEE	24.88	25841592
326	Phosphorylation	SRNLSMDSLVVPLPN CCCCCCCEEEEECCC	17.89	29496963
350	Phosphorylation	TVLPRNNSIGESLSS EECCCCCCHHHHHHH	35.20	22617229
354	Phosphorylation	RNNSIGESLSSQYKS CCCCHHHHHHHHHHC	28.48	23312004
359	Phosphorylation	GESLSSQYKSSMALG HHHHHHHHHCCCCCC	18.13	30174305
361	Phosphorylation	SLSSQYKSSMALGPG HHHHHHHCCCCCCCC	22.03	21406692
362	Phosphorylation	LSSQYKSSMALGPGA HHHHHHCCCCCCCCC	12.15	21406692
374	Phosphorylation	PGAGQLLSPGAARRQ CCCCCCCCCHHHHHH	29.85	28188228
384	Phosphorylation	AARRQFGSNTSLHLL HHHHHHCCCCHHHHH	37.92	24961811
386	Phosphorylation	RRQFGSNTSLHLLSS HHHHCCCCHHHHHHH	34.07	29496963
387	Phosphorylation	RQFGSNTSLHLLSSH HHHCCCCHHHHHHHC	20.31	29496963
397	Phosphorylation	LLSSHSKSLDLDRGP HHHHCCCCCCCCCCC	30.08	22617229
405	Phosphorylation	LDLDRGPSTLTVQAE CCCCCCCCEEEEEHH	38.58	28857561
406	Phosphorylation	DLDRGPSTLTVQAEQ CCCCCCCEEEEEHHH	29.58	28857561
418	Phosphorylation	AEQRKHPSWPRLDRN HHHCCCCCCCCCCCC	49.81	24719451
427	Phosphorylation	PRLDRNNSKGYMKLE CCCCCCCCCCCCCCC	30.89	-
430	Phosphorylation	DRNNSKGYMKLENKE CCCCCCCCCCCCCCC	8.53	-
464	Phosphorylation	KEKLLMISRSHNNLS HHHEEEEECCCCCCC	17.48	29514088
466	Phosphorylation	KLLMISRSHNNLSFE HEEEEECCCCCCCCC	24.63	30576142
471	Phosphorylation	SRSHNNLSFEHDEFL ECCCCCCCCCCHHHH	30.61	29496963
486	Phosphorylation	SNNLKRGTSETRF-- HHHCCCCCCCCCC--	27.67	29514088
487	Phosphorylation	NNLKRGTSETRF--- HHCCCCCCCCCC---	39.53	29514088
489	Phosphorylation	LKRGTSETRF----- CCCCCCCCCC-----	36.82	29514088

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of T200A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of T200A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of T200A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PP2BC_HUMAN	PPP3CC	physical	28514442
FHOD1_HUMAN	FHOD1	physical	28514442
PP2BB_HUMAN	PPP3CB	physical	28514442
CANB1_HUMAN	PPP3R1	physical	28514442
MYADM_HUMAN	MYADM	physical	28514442
STX6_HUMAN	STX6	physical	28514442
STX10_HUMAN	STX10	physical	28514442
PP2BA_HUMAN	PPP3CA	physical	28514442
GOSR1_HUMAN	GOSR1	physical	28514442
STX7_HUMAN	STX7	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.