PRR5L_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PRR5L_HUMAN
• UniProt AC: Q6MZQ0
• Protein Name: Proline-rich protein 5-like
• Gene Name: PRR5L
• Organism: Homo sapiens (Human).
• Sequence Length: 368
• Protein Description: Associates with the mTORC2 complex that regulates cellular processes including survival and organization of the cytoskeleton. [PubMed: 17461779 Regulates the activity of the mTORC2 complex in a substrate-specific manner preventing for instance the specific phosphorylation of PKCs and thereby controlling cell migration]
• Protein Sequence: MTRGFAPILPVEFHKMGSFRRPRPRFMSSPVLSDLPRFQAARQALQLSSSSAWNSVQTAVINVFKGGGLQSNELYALNENIRRLLKSELGSFITDYFQNQLLAKGLFFVEEKIKLCEGENRIEVLAEVWDHFFTETLPTLQAIFYPVQGQELTIRQISLLGFRDLVLLKVKLGDLLLLAQSKLPSSIVQMLLILQSVHEPTGPSESYLQLEELVKQVVSPFLGISGDRSFSGPTYTLARRHSRVRPKVTVLNYASPITAVSRPLNEMVLTPLTEQEGEAYLEKCGSVRRHTVANAHSDIQLLAMATMMHSGLGEEASSENKCLLLPPSFPPPHRQCSSEPNITDNPDGLEEGARGSQEGSELNCASLS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
28	Phosphorylation	RPRPRFMSSPVLSDL CCCCCCCCCCCHHCC	28.86	23401153
29	Phosphorylation	PRPRFMSSPVLSDLP CCCCCCCCCCHHCCH	13.77	29255136
33	Phosphorylation	FMSSPVLSDLPRFQA CCCCCCHHCCHHHHH	37.02	23403867
71	Phosphorylation	FKGGGLQSNELYALN HCCCCCCHHHHHHHH	37.00	27499020
86	Ubiquitination	ENIRRLLKSELGSFI HHHHHHHHHHHHHHH	46.61	-
96	Phosphorylation	LGSFITDYFQNQLLA HHHHHHHHHHHHHHH	9.83	-
112	Ubiquitination	GLFFVEEKIKLCEGE CCCCHHHHHHHCCCC	31.47	-
181	Phosphorylation	DLLLLAQSKLPSSIV HHHHHHCCCCCHHHH	30.47	-
182	Acetylation	LLLLAQSKLPSSIVQ HHHHHCCCCCHHHHH	52.95	12393115
229	Phosphorylation	LGISGDRSFSGPTYT HCCCCCCCCCCCCHH	28.62	28060719
231	Phosphorylation	ISGDRSFSGPTYTLA CCCCCCCCCCCHHHH	45.14	28060719
234	Phosphorylation	DRSFSGPTYTLARRH CCCCCCCCHHHHCCC	32.44	28060719
235	Phosphorylation	RSFSGPTYTLARRHS CCCCCCCHHHHCCCC	11.68	28060719
236	Phosphorylation	SFSGPTYTLARRHSR CCCCCCHHHHCCCCC	19.20	28060719
283	Ubiquitination	EGEAYLEKCGSVRRH HHHHHHHHHCCCCCH	41.10	-
337	Phosphorylation	PPPHRQCSSEPNITD CCCCCCCCCCCCCCC	29.42	29116813
356	Phosphorylation	LEEGARGSQEGSELN CCCCCCCCCCCCCCC	21.36	27690223
360	Phosphorylation	ARGSQEGSELNCASL CCCCCCCCCCCCCCC	37.85	27690223
366	Phosphorylation	GSELNCASLS----- CCCCCCCCCC-----	31.20	23312004
368	Phosphorylation	ELNCASLS------- CCCCCCCC-------	35.36	22617229

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	RFFL	Q8WZ73	PMID:22609986

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PRR5L_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PRR5L_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MTOR_HUMAN	MTOR	physical	18030348
RICTR_HUMAN	RICTOR	physical	18030348
SIN1_HUMAN	MAPKAP1	physical	18030348
TTP_HUMAN	ZFP36	physical	21964062

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.