ATOH1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ATOH1_HUMAN
• UniProt AC: Q92858
• Protein Name: Protein atonal homolog 1
• Gene Name: ATOH1
• Organism: Homo sapiens (Human).
• Sequence Length: 354
• Subcellular Localization: Nucleus .
• Protein Description: Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity)..
• Protein Sequence: MSRLLHAEEWAEVKELGDHHRQPQPHHLPQPPPPPQPPATLQAREHPVYPPELSLLDSTDPRAWLAPTLQGICTARAAQYLLHSPELGASEAAAPRDEVDGRGELVRRSSGGASSSKSPGPVKVREQLCKLKGGVVVDELGCSRQRAPSSKQVNGVQKQRRLAANARERRRMHGLNHAFDQLRNVIPSFNNDKKLSKYETLQMAQIYINALSELLQTPSGGEQPPPPPASCKSDHHHLRTAASYEGGAGNATAAGAQQASGGSQRPTPPGSCRTRFSAPASAGGYSVQLDALHFSTFEDSALTAMMAQKNLSPSLPGSILQPVQEENSKTSPRSHRSDGEFSPHSHYSDSDEAS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
49	Phosphorylation	QAREHPVYPPELSLL EECCCCCCCCCHHCC	19.95	26657352
58	Phosphorylation	PELSLLDSTDPRAWL CCHHCCCCCCCCHHH	34.38	26657352
59	Phosphorylation	ELSLLDSTDPRAWLA CHHCCCCCCCCHHHH	50.09	26657352
80	Phosphorylation	CTARAAQYLLHSPEL HHHHHHHHHHHCCCC	13.40	23312004
84	Phosphorylation	AAQYLLHSPELGASE HHHHHHHCCCCCCCC	21.75	23312004
150	Phosphorylation	SRQRAPSSKQVNGVQ CCCCCCCCHHCCHHH	26.50	-
345	Phosphorylation	DGEFSPHSHYSDSDE CCCCCCCCCCCCCCC	27.75	-
347	Phosphorylation	EFSPHSHYSDSDEAS CCCCCCCCCCCCCCC	19.72	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	HUWE1	Q7Z6Z7	PMID:27542412

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ATOH1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ATOH1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HUWE1_HUMAN	HUWE1	physical	27542412
PRKDC_HUMAN	PRKDC	physical	27542412
MAP1B_HUMAN	MAP1B	physical	27542412
DYHC1_HUMAN	DYNC1H1	physical	27542412
KIF11_HUMAN	KIF11	physical	27542412
SRRM2_HUMAN	SRRM2	physical	27542412
MACF1_HUMAN	MACF1	physical	27542412
MYCB2_HUMAN	MYCBP2	physical	27542412
MDN1_HUMAN	MDN1	physical	27542412
HERC2_HUMAN	HERC2	physical	27542412
RN213_HUMAN	RNF213	physical	27542412
UBR5_HUMAN	UBR5	physical	27542412
UTRO_HUMAN	UTRN	physical	27542412
MGAP_HUMAN	MGA	physical	27542412
AKAP9_HUMAN	AKAP9	physical	27542412
PRC2C_HUMAN	PRRC2C	physical	27542412
CE350_HUMAN	CEP350	physical	27542412
SON_HUMAN	SON	physical	27542412
PLEC_HUMAN	PLEC	physical	27542412
MAP1A_HUMAN	MAP1A	physical	27542412
DMXL1_HUMAN	DMXL1	physical	27542412
TRRAP_HUMAN	TRRAP	physical	27542412
SACS_HUMAN	SACS	physical	27542412
GOGB1_HUMAN	GOLGB1	physical	27542412
TBB2A_HUMAN	TUBB2A	physical	27542412
TBA1A_HUMAN	TUBA1A	physical	27542412
RL4_HUMAN	RPL4	physical	27542412
EF1A1_HUMAN	EEF1A1	physical	27542412
EFTU_HUMAN	TUFM	physical	27542412
RL3_HUMAN	RPL3	physical	27542412
LA_HUMAN	SSB	physical	27542412
RBMX_HUMAN	RBMX	physical	27542412
ENOA_HUMAN	ENO1	physical	27542412
PRS8_HUMAN	PSMC5	physical	27542412
PRS7_HUMAN	PSMC2	physical	27542412
SYYM_HUMAN	YARS2	physical	27542412
TBA1C_HUMAN	TUBA1C	physical	27542412
SERPH_HUMAN	SERPINH1	physical	27542412
KC1D_HUMAN	CSNK1D	physical	27542412
KC1E_HUMAN	CSNK1E	physical	27542412
ACOX1_HUMAN	ACOX1	physical	27542412
ODBA_HUMAN	BCKDHA	physical	27542412
PRPS1_HUMAN	PRPS1	physical	27542412
TBB2B_HUMAN	TUBB2B	physical	27542412
TBA4A_HUMAN	TUBA4A	physical	27542412
PRDX4_HUMAN	PRDX4	physical	27542412
AAMP_HUMAN	AAMP	physical	27542412
UBP11_HUMAN	USP11	physical	27542412
UBP47_HUMAN	USP47	physical	27542412
TFE2_HUMAN	TCF3	physical	27542412
HTF4_HUMAN	TCF12	physical	27542412
AHSA1_HUMAN	AHSA1	physical	27542412
AT2A1_HUMAN	ATP2A1	physical	27542412
MK03_HUMAN	MAPK3	physical	27542412
SORCN_HUMAN	SRI	physical	27542412
ENAH_HUMAN	ENAH	physical	27542412
FLNC_HUMAN	FLNC	physical	27542412
GFAP_HUMAN	GFAP	physical	27542412
PDE4D_HUMAN	PDE4D	physical	27542412
4F2_HUMAN	SLC3A2	physical	27542412
ZYX_HUMAN	ZYX	physical	27542412
CC124_HUMAN	CCDC124	physical	27542412
HEM6_HUMAN	CPOX	physical	27542412
PYRG2_HUMAN	CTPS2	physical	27542412
AGO1_HUMAN	AGO1	physical	27542412
AGO2_HUMAN	AGO2	physical	27542412
AGO3_HUMAN	AGO3	physical	27542412
FHL3_HUMAN	FHL3	physical	27542412
NEK9_HUMAN	NEK9	physical	27542412
NT5D2_HUMAN	NT5DC2	physical	27542412
PDXK_HUMAN	PDXK	physical	27542412
SC23A_HUMAN	SEC23A	physical	27542412
SC23B_HUMAN	SEC23B	physical	27542412
TNR6C_HUMAN	TNRC6C	physical	27542412
KC1A_HUMAN	CSNK1A1	physical	27542412

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.