dbPTM

CP072_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CP072_HUMAN
UniProt AC	Q14CZ0
Protein Name	UPF0472 protein C16orf72
Gene Name	C16orf72
Organism	Homo sapiens (Human).
Sequence Length	275
Subcellular Localization
Protein Description
Protein Sequence	MEERKEEGEAEIQEHGPEHWFSKWERQCLAEAEQDEQLPPELQEEAAAAAQPEHKQQKLWHLFQNSATAVAQLYKDRVCQQPGLSLWVPFQNAATAVTNLYKESVDTHQRSFDIGIQIGYQRRNKDVLAWVKKRRRTIRREDLISFLCGKVPPPRNSRAPPRLTVVSPNRATSTETSSSVETDLQPFREAIALHGLSGAMASISVRSSTPGSPTHVSSGSNASRRRNGLHDVDLNTFISEEMALHLDNGGTRKRTSAQCGDVITDSPTHKRNRMI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Ubiquitination	---MEERKEEGEAEI ---CHHHHHHCCHHH	64.50	29967540
23	Ubiquitination	GPEHWFSKWERQCLA CHHHHCHHHHHHHHH	43.53	29967540
55	Ubiquitination	AAAQPEHKQQKLWHL HHCCCHHHHHHHHHH	53.41	29967540
132	Ubiquitination	KDVLAWVKKRRRTIR CCHHHHHHHHCCCCC	29.84	33845483
133	Ubiquitination	DVLAWVKKRRRTIRR CHHHHHHHHCCCCCH	41.33	-
150	Ubiquitination	LISFLCGKVPPPRNS HHHHHHCCCCCCCCC	51.04	-
164	Phosphorylation	SRAPPRLTVVSPNRA CCCCCCEEEECCCCC	21.82	28464451
167	Phosphorylation	PPRLTVVSPNRATST CCCEEEECCCCCCCC	16.48	19664994
172	Phosphorylation	VVSPNRATSTETSSS EECCCCCCCCCCCCC	32.70	27282143
173	Phosphorylation	VSPNRATSTETSSSV ECCCCCCCCCCCCCC	24.22	29083192
174	Phosphorylation	SPNRATSTETSSSVE CCCCCCCCCCCCCCC	38.64	27282143
176	Phosphorylation	NRATSTETSSSVETD CCCCCCCCCCCCCCC	33.72	29083192
177	Phosphorylation	RATSTETSSSVETDL CCCCCCCCCCCCCCC	17.87	29083192
178	Phosphorylation	ATSTETSSSVETDLQ CCCCCCCCCCCCCCH	45.91	29083192
179	Phosphorylation	TSTETSSSVETDLQP CCCCCCCCCCCCCHH	24.60	29083192
197	Phosphorylation	AIALHGLSGAMASIS HHHHHCCCCCEEEEE	29.15	24719451
202	Phosphorylation	GLSGAMASISVRSST CCCCCEEEEEEECCC	11.43	-
204	Phosphorylation	SGAMASISVRSSTPG CCCEEEEEEECCCCC	14.69	24719451
207	Phosphorylation	MASISVRSSTPGSPT EEEEEEECCCCCCCC	36.09	23401153
208	Phosphorylation	ASISVRSSTPGSPTH EEEEEECCCCCCCCC	28.23	28387310
209	Phosphorylation	SISVRSSTPGSPTHV EEEEECCCCCCCCCC	32.68	22199227
212	Phosphorylation	VRSSTPGSPTHVSSG EECCCCCCCCCCCCC	28.03	27794612
214	Phosphorylation	SSTPGSPTHVSSGSN CCCCCCCCCCCCCCC	36.29	30576142
217	Phosphorylation	PGSPTHVSSGSNASR CCCCCCCCCCCCHHC	22.75	27732954
218	Phosphorylation	GSPTHVSSGSNASRR CCCCCCCCCCCHHCC	45.19	23186163
220	Phosphorylation	PTHVSSGSNASRRRN CCCCCCCCCHHCCCC	31.04	23186163
223	Phosphorylation	VSSGSNASRRRNGLH CCCCCCHHCCCCCCC	30.48	23186163
255	Phosphorylation	NGGTRKRTSAQCGDV CCCCCCCCCCCCCCC	31.30	23186163
256	Phosphorylation	GGTRKRTSAQCGDVI CCCCCCCCCCCCCCC	22.00	23186163
264	Phosphorylation	AQCGDVITDSPTHKR CCCCCCCCCCCCCCC	30.21	27732954
266	Phosphorylation	CGDVITDSPTHKRNR CCCCCCCCCCCCCCC	24.05	30576142
268	Phosphorylation	DVITDSPTHKRNRMI CCCCCCCCCCCCCCC	43.94	30576142
270	Ubiquitination	ITDSPTHKRNRMI-- CCCCCCCCCCCCC--	54.57	32015554

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CP072_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CP072_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CP072_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
FAM9B_HUMAN	FAM9B	physical	24722188
FAM9B_HUMAN	FAM9B	physical	25416956

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CP072_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-167, AND MASSSPECTROMETRY.	18669648 [Abstract]