KCT2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KCT2_HUMAN
• UniProt AC: Q8NC54
• Protein Name: Keratinocyte-associated transmembrane protein 2
• Gene Name: KCT2
• Organism: Homo sapiens (Human).
• Sequence Length: 265
• Subcellular Localization: Membrane ; Single-pass type I membrane protein .
• Protein Sequence: MAAAVPKRMRGPAQAKLLPGSAIQALVGLARPLVLALLLVSAALSSVVSRTDSPSPTVLNSHISTPNVNALTHENQTKPSISQISTTLPPTTSTKKSGGASVVPHPSPTPLSQEEADNNEDPSIEEEDLLMLNSSPSTAKDTLDNGDYGEPDYDWTTGPRDDDESDDTLEENRGYMEIEQSVKSFKMPSSNIEEEDSHFFFHLIIFAFCIAVVYITYHNKRKIFLLVQSRKWRDGLCSKTVEYHRLDQNVNEAMPSLKITNDYIF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
75	N-linked_Glycosylation	VNALTHENQTKPSIS HHHCCCCCCCCCCHH	47.41	UniProtKB CARBOHYD
87	O-linked_Glycosylation	SISQISTTLPPTTST CHHHEECCCCCCCCC	30.40	OGP
165	Phosphorylation	GPRDDDESDDTLEEN CCCCCCCCCCCHHHH	48.02	29759185
168	Phosphorylation	DDDESDDTLEENRGY CCCCCCCCHHHHHCH	40.85	29759185
175	Phosphorylation	TLEENRGYMEIEQSV CHHHHHCHHHHHHHH	6.58	19664994
183	Ubiquitination	MEIEQSVKSFKMPSS HHHHHHHHHCCCCCC	56.26	21890473
186	Ubiquitination	EQSVKSFKMPSSNIE HHHHHHCCCCCCCCC	57.92	22817900
229	Phosphorylation	KIFLLVQSRKWRDGL EEEEEEECCCCCCCC	28.48	21712546
237	S-palmitoylation	RKWRDGLCSKTVEYH CCCCCCCCCCCEEHH	4.85	29575903
238	Phosphorylation	KWRDGLCSKTVEYHR CCCCCCCCCCEEHHH	36.08	27134283
239	Ubiquitination	WRDGLCSKTVEYHRL CCCCCCCCCEEHHHC	56.44	23000965
240	Phosphorylation	RDGLCSKTVEYHRLD CCCCCCCCEEHHHCC	11.41	19651622
243	Phosphorylation	LCSKTVEYHRLDQNV CCCCCEEHHHCCCCH	6.47	25884760
256	Phosphorylation	NVNEAMPSLKITNDY CHHHHCCCCCCCCCC	29.25	25159151
258	Ubiquitination	NEAMPSLKITNDYIF HHHCCCCCCCCCCCC	52.39	21906983
260	Phosphorylation	AMPSLKITNDYIF-- HCCCCCCCCCCCC--	22.05	24719451
263	Phosphorylation	SLKITNDYIF----- CCCCCCCCCC-----	13.29	28796482

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KCT2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KCT2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KCT2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.