| UniProt ID | TRI58_HUMAN | |
|---|---|---|
| UniProt AC | Q8NG06 | |
| Protein Name | E3 ubiquitin-protein ligase TRIM58 | |
| Gene Name | TRIM58 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 486 | |
| Subcellular Localization | ||
| Protein Description | E3 ubiquitin ligase induced during late erythropoiesis. Directly binds and ubiquitinates the intermediate chain of the microtubule motor dynein (DYNC1LI1/DYNC1LI2), stimulating the degradation of the dynein holoprotein complex. May participate in the erythroblast enucleation process through regulation of nuclear polarization.. | |
| Protein Sequence | MAWAPPGERLREDARCPVCLDFLQEPVSVDCGHSFCLRCISEFCEKSDGAQGGVYACPQCRGPFRPSGFRPNRQLAGLVESVRRLGLGAGPGARRCARHGEDLSRFCEEDEAALCWVCDAGPEHRTHRTAPLQEAAGSYQVKLQMALELMRKELEDALTQEANVGKKTVIWKEKVEMQRQRFRLEFEKHRGFLAQEEQRQLRRLEAEERATLQRLRESKSRLVQQSKALKELADELQERCQRPALGLLEGVRGVLSRSKAVTRLEAENIPMELKTACCIPGRRELLRKFQVDVKLDPATAHPSLLLTADLRSVQDGEPWRDVPNNPERFDTWPCILGLQSFSSGRHYWEVLVGEGAEWGLGVCQDTLPRKGETTPSPENGVWALWLLKGNEYMVLASPSVPLLQLESPRCIGIFLDYEAGEISFYNVTDGSYIYTFNQLFSGLLRPYFFICDATPLILPPTTIAGSGNWASRDHLDPASDVRDDHL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 47 | Phosphorylation | ISEFCEKSDGAQGGV HHHHHHHCCCCCCCE | 20.98 | 28258704 | |
| 55 | Phosphorylation | DGAQGGVYACPQCRG CCCCCCEEECCCCCC | 13.03 | 28258704 | |
| 159 | Phosphorylation | KELEDALTQEANVGK HHHHHHHHHHCCCCC | 26.53 | - | |
| 256 | Phosphorylation | EGVRGVLSRSKAVTR HHHHHHHHCCCHHHH | 31.91 | 24719451 | |
| 392 | Phosphorylation | WLLKGNEYMVLASPS EEEECCEEEEEECCC | 9.12 | - | |
| 397 | Phosphorylation | NEYMVLASPSVPLLQ CEEEEEECCCCCEEE | 17.34 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TRI58_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TRI58_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TRI58_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| DYHC1_HUMAN | DYNC1H1 | physical | 25241935 | |
| DC1I1_HUMAN | DYNC1I1 | physical | 25241935 | |
| DC2L1_HUMAN | DYNC2LI1 | physical | 25241935 | |
| DC1L2_HUMAN | DYNC1LI2 | physical | 25241935 | |
| TRI58_HUMAN | TRIM58 | physical | 25241935 | |
| UB2D3_HUMAN | UBE2D3 | physical | 25241935 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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