dbPTM

MMAA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MMAA_HUMAN
UniProt AC	Q8IVH4
Protein Name	Methylmalonic aciduria type A protein, mitochondrial {ECO:0000305}
Gene Name	MMAA {ECO:0000312\|HGNC:HGNC:18871}
Organism	Homo sapiens (Human).
Sequence Length	418
Subcellular Localization	Mitochondrion .
Protein Description	GTPase, binds and hydrolyzes GTP. [PubMed: 28497574]
Protein Sequence	MPMLLPHPHQHFLKGLLRAPFRCYHFIFHSSTHLGSGIPCAQPFNSLGLHCTKWMLLSDGLKRKLCVQTTLKDHTEGLSDKEQRFVDKLYTGLIQGQRACLAEAITLVESTHSRKKELAQVLLQKVLLYHREQEQSNKGKPLAFRVGLSGPPGAGKSTFIEYFGKMLTERGHKLSVLAVDPSSCTSGGSLLGDKTRMTELSRDMNAYIRPSPTRGTLGGVTRTTNEAILLCEGAGYDIILIETVGVGQSEFAVADMVDMFVLLLPPAGGDELQGIKRGIIEMADLVAVTKSDGDLIVPARRIQAEYVSALKLLRKRSQVWKPKVIRISARSGEGISEMWDKMKDFQDLMLASGELTAKRRKQQKVWMWNLIQESVLEHFRTHPTVREQIPLLEQKVLIGALSPGLAADFLLKAFKSRD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
88	Acetylation	KEQRFVDKLYTGLIQ HHHHHHHHHHHHHHH	37.78	25038526
110	Phosphorylation	EAITLVESTHSRKKE HHHHHHHCCCCCHHH	24.76	-
111	Phosphorylation	AITLVESTHSRKKEL HHHHHHCCCCCHHHH	15.46	-
113	Phosphorylation	TLVESTHSRKKELAQ HHHHCCCCCHHHHHH	45.97	-
116	Malonylation	ESTHSRKKELAQVLL HCCCCCHHHHHHHHH	57.77	26320211
186	Phosphorylation	VDPSSCTSGGSLLGD ECHHHCCCCCCCCCC	45.55	27762562
189	Phosphorylation	SSCTSGGSLLGDKTR HHCCCCCCCCCCHHH	24.77	-
194	Ubiquitination	GGSLLGDKTRMTELS CCCCCCCHHHHCHHH	35.91	-
213	Phosphorylation	AYIRPSPTRGTLGGV CCCCCCCCCCCCCCE	46.17	22210691
311	Ubiquitination	AEYVSALKLLRKRSQ HHHHHHHHHHHHHHC	45.23	-
321	Malonylation	RKRSQVWKPKVIRIS HHHHCCCCCEEEEEE	35.78	26320211
331	Phosphorylation	VIRISARSGEGISEM EEEEECCCCCCHHHH	40.70	-
336	Phosphorylation	ARSGEGISEMWDKMK CCCCCCHHHHHHHHH	32.05	-
341	Acetylation	GISEMWDKMKDFQDL CHHHHHHHHHHHHHH	32.13	25038526
352	Phosphorylation	FQDLMLASGELTAKR HHHHHHHCCCCCHHH	28.92	22817900
395	Acetylation	QIPLLEQKVLIGALS HCHHHHHHHHHHHCC	29.63	25038526
402	Phosphorylation	KVLIGALSPGLAADF HHHHHHCCHHHHHHH	19.18	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MMAA_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MMAA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MMAA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
MMAA_HUMAN	MMAA	physical	20876572
MUTA_HUMAN	MUT	physical	20876572

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
251100	Methylmalonic aciduria type cblA (MMAA)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00115	Cyanocobalamin
DB00200	Hydroxocobalamin

Regulatory Network of MMAA_HUMAN

Related Literatures of Post-Translational Modification