dbPTM

GWL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GWL_HUMAN
UniProt AC	Q96GX5
Protein Name	Serine/threonine-protein kinase greatwall
Gene Name	MASTL
Organism	Homo sapiens (Human).
Sequence Length	879
Subcellular Localization	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Nucleus . Cleavage furrow . During interphase is mainly nuclear, upon nuclear envelope breakdown localizes at the cytoplasm and during mitosis at the centrosomes. Upon mitotic exit
Protein Description	Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation..
Protein Sequence	MDPTAGSKKEPGGGAATEEGVNRIAVPKPPSIEEFSIVKPISRGAFGKVYLGQKGGKLYAVKVVKKADMINKNMTHQVQAERDALALSKSPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTPSMAKPRQDYSRTPGQVLSLISSLGFNTPIAEKNQDPANILSACLSETSQLSQGLVCPMSVDQKDTTPYSSKLLKSCLETVASNPGMPVKCLTSNLLQSRKRLATSSASSQSHTFISSVESECHSSPKWEKDCQESDEALGPTMMSWNAVEKLCAKSANAIETKGFNKKDLELALSPIHNSSALPTTGRSCVNLAKKCFSGEVSWEAVELDVNNINMDTDTSQLGFHQSNQWAVDSGGISEEHLGKRSLKRNFELVDSSPCKKIIQNKKTCVEYKHNEMTNCYTNQNTGLTVEVQDLKLSVHKSQQNDCANKENIVNSFTDKQQTPEKLPIPMIAKNLMCELDEDCEKNSKRDYLSSSFLCSDDDRASKNISMNSDSSFPGISIMESPLESQPLDSDRSIKESSFEESNIEDPLIVTPDCQEKTSPKGVENPAVQESNQKMLGPPLEVLKTLASKRNAVAFRSFNSHINASNNSEPSRMNMTSLDAMDISCAYSGSYPMAITPTQKRRSCMPHQQTPNQIKSGTPYRTPKSVRRGVAPVDDGRILGTPDYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRDIPWPEGEEKLSDNAQSAVEILLTIDDTKRAGMKELKRHPLFSDVDWENLQHQTMPFIPQPDDETDTSYFEARNTAQHLTVSGFSL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDPTAGSK -------CCCCCCCC	14.55	22814378
8	Acetylation	MDPTAGSKKEPGGGA CCCCCCCCCCCCCCC	61.30	26051181
8	Ubiquitination	MDPTAGSKKEPGGGA CCCCCCCCCCCCCCC	61.30	-
9	Acetylation	DPTAGSKKEPGGGAA CCCCCCCCCCCCCCC	71.49	26051181
9	Ubiquitination	DPTAGSKKEPGGGAA CCCCCCCCCCCCCCC	71.49	-
17	Phosphorylation	EPGGGAATEEGVNRI CCCCCCCCCCCCCCC	33.75	22210691
18	Ubiquitination	PGGGAATEEGVNRIA CCCCCCCCCCCCCCC	48.29	32015554
28	Ubiquitination	VNRIAVPKPPSIEEF CCCCCCCCCCCCHHC	64.06	29967540
31	Phosphorylation	IAVPKPPSIEEFSIV CCCCCCCCCHHCEEE	51.68	-
39	Ubiquitination	IEEFSIVKPISRGAF CHHCEEEEEECCCCC	34.66	23000965
39 (in isoform 1)	Ubiquitination	-	34.66	21890473
39 (in isoform 2)	Ubiquitination	-	34.66	21890473
39 (in isoform 3)	Ubiquitination	-	34.66	21890473
48	Ubiquitination	ISRGAFGKVYLGQKG ECCCCCCEEEECCCC	22.66	29967540
54	Ubiquitination	GKVYLGQKGGKLYAV CEEEECCCCCEEEEE	68.76	29967540
57	Acetylation	YLGQKGGKLYAVKVV EECCCCCEEEEEEEE	47.17	25953088
57	Ubiquitination	YLGQKGGKLYAVKVV EECCCCCEEEEEEEE	47.17	29967540
62	Ubiquitination	GGKLYAVKVVKKADM CCEEEEEEEEEHHHH	32.89	22817900
65	Ubiquitination	LYAVKVVKKADMINK EEEEEEEEHHHHCCC	45.27	22817900
66	Ubiquitination	YAVKVVKKADMINKN EEEEEEEHHHHCCCC	37.70	22817900
66 (in isoform 1)	Ubiquitination	-	37.70	21890473
66 (in isoform 2)	Ubiquitination	-	37.70	21890473
66 (in isoform 3)	Ubiquitination	-	37.70	21890473
72	Ubiquitination	KKADMINKNMTHQVQ EHHHHCCCCCHHHHH	36.85	29967540
75	Phosphorylation	DMINKNMTHQVQAER HHCCCCCHHHHHHHH	20.67	-
108	Ubiquitination	QSANNVYLVMEYLIG CCCCCEEEEEEHHHC	2.29	32015554
109	Ubiquitination	SANNVYLVMEYLIGG CCCCEEEEEEHHHCC	1.18	22817900
130	Ubiquitination	HIYGYFDEEMAVKYI HHHCCCCHHHHHHHH	39.51	21963094
150	Ubiquitination	ALDYLHRHGIIHRDL HHHHHHHCCCCCCCC	22.51	22817900
158	Ubiquitination	GIIHRDLKPDNMLIS CCCCCCCCCCCEEEC	55.40	22817900
158 (in isoform 1)	Ubiquitination	-	55.40	21890473
158 (in isoform 2)	Ubiquitination	-	55.40	21890473
158 (in isoform 3)	Ubiquitination	-	55.40	21890473
173	Phosphorylation	NEGHIKLTDFGLSKV CCCCEEECCCCCCEE	25.04	22210691
178	Phosphorylation	KLTDFGLSKVTLNRD EECCCCCCEEEECCC	26.01	22210691
179	Ubiquitination	LTDFGLSKVTLNRDI ECCCCCCEEEECCCC	44.26	21906983
179 (in isoform 1)	Ubiquitination	-	44.26	21890473
179 (in isoform 2)	Ubiquitination	-	44.26	21890473
179 (in isoform 3)	Ubiquitination	-	44.26	21890473
181	Phosphorylation	DFGLSKVTLNRDINM CCCCCEEEECCCCCC	23.27	24260401
189	Ubiquitination	LNRDINMMDILTTPS ECCCCCCHHHHCCCC	2.21	32015554
193	Phosphorylation	INMMDILTTPSMAKP CCCHHHHCCCCCCCC	36.67	20068231
194	Phosphorylation	NMMDILTTPSMAKPR CCHHHHCCCCCCCCC	15.21	21712546
196	Phosphorylation	MDILTTPSMAKPRQD HHHHCCCCCCCCCCC	29.31	28122231
199	Ubiquitination	LTTPSMAKPRQDYSR HCCCCCCCCCCCCCC	31.90	22817900
199 (in isoform 1)	Ubiquitination	-	31.90	21890473
199 (in isoform 2)	Ubiquitination	-	31.90	21890473
199 (in isoform 3)	Ubiquitination	-	31.90	21890473
204	Phosphorylation	MAKPRQDYSRTPGQV CCCCCCCCCCCHHHH	7.54	22199227
205	Phosphorylation	AKPRQDYSRTPGQVL CCCCCCCCCCHHHHH	37.66	22199227
207	Phosphorylation	PRQDYSRTPGQVLSL CCCCCCCCHHHHHHH	26.32	25159151
213	Phosphorylation	RTPGQVLSLISSLGF CCHHHHHHHHHHCCC	25.46	22199227
216	Phosphorylation	GQVLSLISSLGFNTP HHHHHHHHHCCCCCC	25.46	22199227
217	Phosphorylation	QVLSLISSLGFNTPI HHHHHHHHCCCCCCH	26.05	22199227
222	Phosphorylation	ISSLGFNTPIAEKNQ HHHCCCCCCHHHHCC	17.51	25159151
258	Sumoylation	CPMSVDQKDTTPYSS CCCCCCCCCCCCCCH	53.21	-
260	Phosphorylation	MSVDQKDTTPYSSKL CCCCCCCCCCCCHHH	36.38	30576142
261	Phosphorylation	SVDQKDTTPYSSKLL CCCCCCCCCCCHHHH	30.29	29396449
263	Phosphorylation	DQKDTTPYSSKLLKS CCCCCCCCCHHHHHH	24.39	28985074
264	Phosphorylation	QKDTTPYSSKLLKSC CCCCCCCCHHHHHHH	23.38	21712546
265	Phosphorylation	KDTTPYSSKLLKSCL CCCCCCCHHHHHHHH	22.83	-
266	Acetylation	DTTPYSSKLLKSCLE CCCCCCHHHHHHHHH	52.47	25953088
266	Ubiquitination	DTTPYSSKLLKSCLE CCCCCCHHHHHHHHH	52.47	29967540
269	Methylation	PYSSKLLKSCLETVA CCCHHHHHHHHHHHH	49.94	115972827
269	Ubiquitination	PYSSKLLKSCLETVA CCCHHHHHHHHHHHH	49.94	32015554
270	Phosphorylation	YSSKLLKSCLETVAS CCHHHHHHHHHHHHH	24.73	21712546
274	Phosphorylation	LLKSCLETVASNPGM HHHHHHHHHHHCCCC	14.39	29214152
277	Phosphorylation	SCLETVASNPGMPVK HHHHHHHHCCCCCHH	38.94	21815630
284	Ubiquitination	SNPGMPVKCLTSNLL HCCCCCHHHHHHHHH	20.04	29967540
288	Phosphorylation	MPVKCLTSNLLQSRK CCHHHHHHHHHHHHH	16.72	21712546
292	Phosphorylation	CLTSNLLQSRKRLAT HHHHHHHHHHHHHHH	44.34	32645325
293	Phosphorylation	LTSNLLQSRKRLATS HHHHHHHHHHHHHHC	39.47	25159151
295	Ubiquitination	SNLLQSRKRLATSSA HHHHHHHHHHHHCCC	57.94	32015554
299	Phosphorylation	QSRKRLATSSASSQS HHHHHHHHCCCCCCC	28.01	23663014
300	O-linked_Glycosylation	SRKRLATSSASSQSH HHHHHHHCCCCCCCC	20.49	23301498
300	Phosphorylation	SRKRLATSSASSQSH HHHHHHHCCCCCCCC	20.49	23663014
301	Phosphorylation	RKRLATSSASSQSHT HHHHHHCCCCCCCCE	28.02	23663014
301	Ubiquitination	RKRLATSSASSQSHT HHHHHHCCCCCCCCE	28.02	30230243
303	Phosphorylation	RLATSSASSQSHTFI HHHHCCCCCCCCEEH	30.75	23663014
304	Phosphorylation	LATSSASSQSHTFIS HHHCCCCCCCCEEHH	35.10	23663014
306	Phosphorylation	TSSASSQSHTFISSV HCCCCCCCCEEHHHH	26.83	23663014
308	Phosphorylation	SASSQSHTFISSVES CCCCCCCEEHHHHHH	28.10	23663014
311	Phosphorylation	SQSHTFISSVESECH CCCCEEHHHHHHHHH	24.92	30108239
312	Phosphorylation	QSHTFISSVESECHS CCCEEHHHHHHHHHC	25.70	23663014
315	Phosphorylation	TFISSVESECHSSPK EEHHHHHHHHHCCCC	43.28	23663014
319	Phosphorylation	SVESECHSSPKWEKD HHHHHHHCCCCCHHH	61.05	25159151
320	Phosphorylation	VESECHSSPKWEKDC HHHHHHCCCCCHHHH	13.56	25159151
322	Ubiquitination	SECHSSPKWEKDCQE HHHHCCCCCHHHHHH	70.68	29967540
330	Phosphorylation	WEKDCQESDEALGPT CHHHHHHCHHHHCCC	18.18	25159151
331	Ubiquitination	EKDCQESDEALGPTM HHHHHHCHHHHCCCH	44.42	32015554
350	Ubiquitination	AVEKLCAKSANAIET HHHHHHHHHCCCCCC	49.45	32015554
355	Ubiquitination	CAKSANAIETKGFNK HHHHCCCCCCCCCCH	7.48	33845483
358	Ubiquitination	SANAIETKGFNKKDL HCCCCCCCCCCHHHH	49.03	29967540
362	Ubiquitination	IETKGFNKKDLELAL CCCCCCCHHHHHHHC	45.46	-
363	Ubiquitination	ETKGFNKKDLELALS CCCCCCHHHHHHHCC	69.52	29967540
370	Phosphorylation	KDLELALSPIHNSSA HHHHHHCCCCCCCCC	19.05	29255136
375	Phosphorylation	ALSPIHNSSALPTTG HCCCCCCCCCCCCCC	11.65	30278072
376	Phosphorylation	LSPIHNSSALPTTGR CCCCCCCCCCCCCCC	38.86	25159151
380	Phosphorylation	HNSSALPTTGRSCVN CCCCCCCCCCCHHHH	42.61	28176443
381	Phosphorylation	NSSALPTTGRSCVNL CCCCCCCCCCHHHHH	28.76	25159151
381	Ubiquitination	NSSALPTTGRSCVNL CCCCCCCCCCHHHHH	28.76	32015554
384	Phosphorylation	ALPTTGRSCVNLAKK CCCCCCCHHHHHHHH	24.62	21712546
390	Ubiquitination	RSCVNLAKKCFSGEV CHHHHHHHHHHCCCC	53.92	29967540
442	Phosphorylation	EEHLGKRSLKRNFEL HHHHCHHHHHHCCEE	41.55	-
452	Phosphorylation	RNFELVDSSPCKKII HCCEECCCCHHHHHH	28.80	30266825
453	Phosphorylation	NFELVDSSPCKKIIQ CCEECCCCHHHHHHC	29.83	19664994
456	Acetylation	LVDSSPCKKIIQNKK ECCCCHHHHHHCCCC	50.84	25953088
456	Ubiquitination	LVDSSPCKKIIQNKK ECCCCHHHHHHCCCC	50.84	32015554
457	Ubiquitination	VDSSPCKKIIQNKKT CCCCHHHHHHCCCCC	52.32	-
462	Ubiquitination	CKKIIQNKKTCVEYK HHHHHCCCCCEEEEE	32.84	30230243
464	Phosphorylation	KIIQNKKTCVEYKHN HHHCCCCCEEEEECC	24.32	26074081
483	Ubiquitination	CYTNQNTGLTVEVQD CEECCCCCCEEEEEE	27.22	32015554
492	Ubiquitination	TVEVQDLKLSVHKSQ EEEEEEEEEEEEHHH	47.18	32015554
497	Ubiquitination	DLKLSVHKSQQNDCA EEEEEEEHHHCCCCC	48.05	29967540
498	Phosphorylation	LKLSVHKSQQNDCAN EEEEEEHHHCCCCCC	23.32	23312004
506	Ubiquitination	QQNDCANKENIVNSF HCCCCCCCHHHHHHC	33.34	29967540
512	Phosphorylation	NKENIVNSFTDKQQT CCHHHHHHCCCCCCC	20.73	29255136
514	Phosphorylation	ENIVNSFTDKQQTPE HHHHHHCCCCCCCCC	41.95	29255136
516	Ubiquitination	IVNSFTDKQQTPEKL HHHHCCCCCCCCCCC	41.05	32015554
519	Phosphorylation	SFTDKQQTPEKLPIP HCCCCCCCCCCCCCC	30.81	25159151
542	Ubiquitination	ELDEDCEKNSKRDYL HCCHHHHHHCCCHHH	73.23	32015554
548	Phosphorylation	EKNSKRDYLSSSFLC HHHCCCHHHHHHCCC	16.71	18691976
550	Phosphorylation	NSKRDYLSSSFLCSD HCCCHHHHHHCCCCC	20.08	29214152
551	Phosphorylation	SKRDYLSSSFLCSDD CCCHHHHHHCCCCCC	23.63	30576142
552	Phosphorylation	KRDYLSSSFLCSDDD CCHHHHHHCCCCCCC	20.89	25159151
556	Phosphorylation	LSSSFLCSDDDRASK HHHHCCCCCCCHHCC	46.34	25159151
566	Phosphorylation	DRASKNISMNSDSSF CHHCCCCCCCCCCCC	22.70	28674151
569	Phosphorylation	SKNISMNSDSSFPGI CCCCCCCCCCCCCCC	30.17	23532336
571	Phosphorylation	NISMNSDSSFPGISI CCCCCCCCCCCCCEE	33.43	28674151
572	Phosphorylation	ISMNSDSSFPGISIM CCCCCCCCCCCCEEE	40.21	28674151
577	Phosphorylation	DSSFPGISIMESPLE CCCCCCCEEECCCCC	23.07	24719451
581	Phosphorylation	PGISIMESPLESQPL CCCEEECCCCCCCCC	19.87	29523821
585	Phosphorylation	IMESPLESQPLDSDR EECCCCCCCCCCCCC	44.79	29523821
590	Phosphorylation	LESQPLDSDRSIKES CCCCCCCCCCCCCHH	42.48	29523821
593	Phosphorylation	QPLDSDRSIKESSFE CCCCCCCCCCHHHCC	42.90	23186163
597	Phosphorylation	SDRSIKESSFEESNI CCCCCCHHHCCCCCC	35.01	30266825
598	Phosphorylation	DRSIKESSFEESNIE CCCCCHHHCCCCCCC	37.46	30266825
602	Phosphorylation	KESSFEESNIEDPLI CHHHCCCCCCCCCEE	35.59	28464451
611	Phosphorylation	IEDPLIVTPDCQEKT CCCCEEECCCCCCCC	13.35	30266825
618	Phosphorylation	TPDCQEKTSPKGVEN CCCCCCCCCCCCCCC	49.89	30266825
619	Phosphorylation	PDCQEKTSPKGVENP CCCCCCCCCCCCCCH	35.36	30266825
621	Ubiquitination	CQEKTSPKGVENPAV CCCCCCCCCCCCHHH	75.30	29967540
631	Phosphorylation	ENPAVQESNQKMLGP CCHHHHHHHHHHHCC	27.72	25159151
634	Ubiquitination	AVQESNQKMLGPPLE HHHHHHHHHHCCCHH	40.10	29967540
644	Acetylation	GPPLEVLKTLASKRN CCCHHHHHHHHHHCC	46.82	18604563
644	Ubiquitination	GPPLEVLKTLASKRN CCCHHHHHHHHHHCC	46.82	32015554
657	Phosphorylation	RNAVAFRSFNSHINA CCCEEEEHHHHCCCC	23.48	25159151
660	Phosphorylation	VAFRSFNSHINASNN EEEEHHHHCCCCCCC	24.59	20068231
665	Phosphorylation	FNSHINASNNSEPSR HHHCCCCCCCCCCCC	31.86	25159151
668	Phosphorylation	HINASNNSEPSRMNM CCCCCCCCCCCCCCC	55.95	25159151
671	Phosphorylation	ASNNSEPSRMNMTSL CCCCCCCCCCCCCHH	39.86	22199227
676	Phosphorylation	EPSRMNMTSLDAMDI CCCCCCCCHHHHHCH	22.57	28348404
677	Phosphorylation	PSRMNMTSLDAMDIS CCCCCCCHHHHHCHH	17.30	28348404
696	Phosphorylation	GSYPMAITPTQKRRS CCCCCEECCCCCCCC	15.67	24719451
703 (in isoform 2)	Phosphorylation	-	20.85	-
703 (in isoform 3)	Phosphorylation	-	20.85	-
709 (in isoform 2)	Phosphorylation	-	56.76	25159151
709 (in isoform 3)	Phosphorylation	-	56.76	25159151
710	Phosphorylation	SCMPHQQTPNQIKSG CCCCCCCCCCCCCCC	20.03	25159151
714	Ubiquitination	HQQTPNQIKSGTPYR CCCCCCCCCCCCCCC	4.95	29967540
715	Ubiquitination	QQTPNQIKSGTPYRT CCCCCCCCCCCCCCC	32.82	29967540
716	Phosphorylation	QTPNQIKSGTPYRTP CCCCCCCCCCCCCCC	49.91	21712546
717 (in isoform 2)	Phosphorylation	-	26.21	25159151
717 (in isoform 3)	Phosphorylation	-	26.21	25159151
718	Phosphorylation	PNQIKSGTPYRTPKS CCCCCCCCCCCCCCH	25.00	25159151
720	Phosphorylation	QIKSGTPYRTPKSVR CCCCCCCCCCCCHHH	27.27	18669648
721 (in isoform 2)	Phosphorylation	-	45.84	25159151
721 (in isoform 3)	Phosphorylation	-	45.84	25159151
722	Phosphorylation	KSGTPYRTPKSVRRG CCCCCCCCCCHHHCC	29.26	18669648
725	Phosphorylation	TPYRTPKSVRRGVAP CCCCCCCHHHCCCCC	23.27	18669648
741	Phosphorylation	DDGRILGTPDYLAPE CCCCCCCCCCCCCHH	15.00	22199227
860	Phosphorylation	QPDDETDTSYFEARN CCCCCCCCCHHHHCH	32.52	-
868	Phosphorylation	SYFEARNTAQHLTVS CHHHHCHHCCCEEEE	23.34	-
873	Phosphorylation	RNTAQHLTVSGFSL- CHHCCCEEEECCCC-	15.53	29396449
875	Phosphorylation	TAQHLTVSGFSL--- HCCCEEEECCCC---	28.96	25159151
878	Phosphorylation	HLTVSGFSL------ CEEEECCCC------	36.37	25159151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
75	T	Phosphorylation	Kinase	PLK1	P70032	PSP
194	T	Phosphorylation	Kinase	CDK1	P06493	PSP
194	T	Phosphorylation	Kinase	CDK2	P24941	PSP
299	T	Phosphorylation	Kinase	AKT1	P31749	PSP
512	S	Phosphorylation	Kinase	PLK1	P70032	PSP
552	S	Phosphorylation	Kinase	PLK1	P70032	PSP
597	S	Phosphorylation	Kinase	PLK1	P70032	PSP
598	S	Phosphorylation	Kinase	PLK1	P70032	PSP
860	T	Phosphorylation	Kinase	PLK1	P70032	PSP
873	T	Phosphorylation	Kinase	PLK1	P70032	PSP
875	S	Phosphorylation	Kinase	CDK1	P06493	PSP
875	S	Phosphorylation	Kinase	PLK1	P70032	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
741	T	Phosphorylation		18669648
Phosphorylation at Thr-741 by CDK1 during M phase activates its kinase activity (By similarity).

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GWL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IGO1_YEAST	IGO1	physical	23861665
CDK18_HUMAN	CDK18	physical	26496610
AAAT_HUMAN	SLC1A5	physical	26496610
SSFA2_HUMAN	SSFA2	physical	26496610
TAP2_HUMAN	TAP2	physical	26496610
MED26_HUMAN	MED26	physical	26496610
TELO2_HUMAN	TELO2	physical	26496610
UBN1_HUMAN	UBN1	physical	26496610
DERL2_HUMAN	DERL2	physical	26496610
RM02_HUMAN	MRPL2	physical	26496610
E41L5_HUMAN	EPB41L5	physical	26496610
FAKD5_HUMAN	FASTKD5	physical	26496610
CEP85_HUMAN	CEP85	physical	26496610
PKHA8_HUMAN	PLEKHA8	physical	26496610
TM263_HUMAN	TMEM263	physical	26496610
ACBD5_HUMAN	ACBD5	physical	26496610

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
188000	Thrombocytopenia 2 (THC2)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GWL_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-370 AND SER-452, ANDMASS SPECTROMETRY.	19369195 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-293; SER-370; SER-452;SER-453; SER-552; SER-556; SER-631; TYR-720; THR-722; SER-725;THR-741; SER-875 AND SER-878, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-370; SER-512; SER-552;SER-657; SER-665; SER-668; SER-875 AND SER-878, AND MASS SPECTROMETRY.	18691976 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-370, AND MASSSPECTROMETRY.	18220336 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-631, AND MASSSPECTROMETRY.	19007248 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-631, AND MASSSPECTROMETRY.	16964243 [Abstract]

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