ZN563_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZN563_HUMAN
• UniProt AC: Q8TA94
• Protein Name: Zinc finger protein 563
• Gene Name: ZNF563
• Organism: Homo sapiens (Human).
• Sequence Length: 476
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in transcriptional regulation..
• Protein Sequence: MDAVAFEDVAVNFTQEEWALLGPSQKNLYRYVMQETIRNLDCIRMIWEEQNTEDQYKNPRRNLRCHMVERFSESKDSSQCGETFSLIRDSIVNNSICPGEDPCQSAECEEVIMGHLSLNSHIRVDSGHKPHEYQEYGEKPHTHKQRGKAFSYHHSFQSRGRPHTGKKRYECKECGKTFSSRRNLRRHMVVQGGNRPYKCKLCGKAFFWPSLLRMHERTHTGEKPYECKQCSKAFPFYSSYRRHERMHTGEKPYECKQCSKALPDSSSYIRHERTHTGEKPYTCKQCGKAFSVSSSLRRHETTHSAEKPYECKQCGKTFHHLGSFQIHMKRHTGDRPHKCKICGKGFDRPSLVRYHERIHTGEKPYECKQCGKTLSHSSSFRRHMIMHTGGGPHKCKICGKAFVYPSVCQRHEKSHSGEKPYECKQCGKALSHSSSFRRHMVMHTGDGPNKCKVCGKAFVYPSVCQRHEKTHWRETI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	EDVAVNFTQEEWALL ECEEECCCHHHHHHH	29.84	-
24	Phosphorylation	EWALLGPSQKNLYRY HHHHHCCCHHHHHHH	52.57	-
77	Phosphorylation	RFSESKDSSQCGETF HHCCCCCHHHCCCHH	26.50	24850871
78	Phosphorylation	FSESKDSSQCGETFS HCCCCCHHHCCCHHH	39.36	24850871
167	Ubiquitination	GRPHTGKKRYECKEC CCCCCCCCCEEECHH	62.65	22505724
186	Ubiquitination	SSRRNLRRHMVVQGG HHHHCHHHCEEEECC	25.97	22505724
191	Ubiquitination	LRRHMVVQGGNRPYK HHHCEEEECCCCCEE	42.54	22505724
210	Phosphorylation	GKAFFWPSLLRMHER CCCCCHHHHHHHHHH	30.54	22617229
218	Phosphorylation	LLRMHERTHTGEKPY HHHHHHHCCCCCCCC	22.32	29396449
220	Phosphorylation	RMHERTHTGEKPYEC HHHHHCCCCCCCCCC	46.56	29496963
223	Ubiquitination	ERTHTGEKPYECKQC HHCCCCCCCCCCCHH	55.00	22505724
237	Phosphorylation	CSKAFPFYSSYRRHE HHCCCCCHHHHCCCC	9.28	-
238	Phosphorylation	SKAFPFYSSYRRHER HCCCCCHHHHCCCCC	22.67	-
239	Phosphorylation	KAFPFYSSYRRHERM CCCCCHHHHCCCCCC	15.98	-
240	Phosphorylation	AFPFYSSYRRHERMH CCCCHHHHCCCCCCC	13.01	-
274	Phosphorylation	SYIRHERTHTGEKPY HHCCCCCCCCCCCCE	22.32	-
276	Phosphorylation	IRHERTHTGEKPYTC CCCCCCCCCCCCEEC	46.56	-
312	Sumoylation	AEKPYECKQCGKTFH CCCCEECCCCCCEEE	36.36	-
312	Sumoylation	AEKPYECKQCGKTFH CCCCEECCCCCCEEE	36.36	-
360	Phosphorylation	RYHERIHTGEKPYEC HHHHHCCCCCCCEEC	44.67	29496963
368	Sumoylation	GEKPYECKQCGKTLS CCCCEECCCCCCCCC	36.36	-
368	Sumoylation	GEKPYECKQCGKTLS CCCCEECCCCCCCCC	36.36	-
373	Phosphorylation	ECKQCGKTLSHSSSF ECCCCCCCCCCCHHH	20.83	21406692
375	Phosphorylation	KQCGKTLSHSSSFRR CCCCCCCCCCHHHHH	26.93	21406692
377	Phosphorylation	CGKTLSHSSSFRRHM CCCCCCCCHHHHHHE	25.05	21406692
378	Phosphorylation	GKTLSHSSSFRRHMI CCCCCCCHHHHHHEE	28.24	21406692
379	Phosphorylation	KTLSHSSSFRRHMIM CCCCCCHHHHHHEEE	26.28	21406692
424	Sumoylation	GEKPYECKQCGKALS CCCCCCCCHHHHHHC	36.36	-
424	Sumoylation	GEKPYECKQCGKALS CCCCCCCCHHHHHHC	36.36	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZN563_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZN563_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZN563_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SHCBP_HUMAN	SHCBP1	physical	28514442
SORL_HUMAN	SORL1	physical	28514442
LRP1B_HUMAN	LRP1B	physical	28514442
UBE2O_HUMAN	UBE2O	physical	28514442
LTBP4_HUMAN	LTBP4	physical	28514442
ERBIN_HUMAN	ERBB2IP	physical	28514442
LRP4_HUMAN	LRP4	physical	28514442
HERC1_HUMAN	HERC1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.