KATL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KATL1_HUMAN
• UniProt AC: Q9BW62
• Protein Name: Katanin p60 ATPase-containing subunit A-like 1 {ECO:0000255|HAMAP-Rule:MF_03024}
• Gene Name: KATNAL1 {ECO:0000255|HAMAP-Rule:MF_03024}
• Organism: Homo sapiens (Human).
• Sequence Length: 490
• Subcellular Localization: Cytoplasm, cytoskeleton . Cytoplasm . Cytoplasm, cytoskeleton, spindle pole . Cytoplasm, cytoskeleton, spindle . Colocalizes with microtubules throughout the basal and adluminal compartments of Sertoli cells (By similarity). Localizes within the cyto
• Protein Description: Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays (By similarity). Has microtubule-severing activity in vitro. [PubMed: 26929214]
• Protein Sequence: MNLAEICDNAKKGREYALLGNYDSSMVYYQGVMQQIQRHCQSVRDPAIKGKWQQVRQELLEEYEQVKSIVSTLESFKIDKPPDFPVSCQDEPFRDPAVWPPPVPAEHRAPPQIRRPNREVRPLRKEMAGVGARGPVGRAHPISKSEKPSTSRDKDYRARGRDDKGRKNMQDGASDGEMPKFDGAGYDKDLVEALERDIVSRNPSIHWDDIADLEEAKKLLREAVVLPMWMPDFFKGIRRPWKGVLMVGPPGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPTAKGRAELLKINLREVELDPDIQLEDIAEKIEGYSGADITNVCRDASLMAMRRRINGLSPEEIRALSKEELQMPVTKGDFELALKKIAKSVSAADLEKYEKWMVEFGSA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MNLAEICD -------CCHHHHHH	9.29	22814378
63	Phosphorylation	RQELLEEYEQVKSIV HHHHHHHHHHHHHHH	11.42	29978859
133	Methylation	EMAGVGARGPVGRAH HHCCCCCCCCCCCCC	43.98	115480835
138	Methylation	GARGPVGRAHPISKS CCCCCCCCCCCCCCC	29.92	24381695
174	Phosphorylation	KNMQDGASDGEMPKF CCCCCCCCCCCCCCC	52.24	25850435
186	Phosphorylation	PKFDGAGYDKDLVEA CCCCCCCCCHHHHHH	21.20	-
188	Ubiquitination	FDGAGYDKDLVEALE CCCCCCCHHHHHHHH	44.47	-
204	Phosphorylation	DIVSRNPSIHWDDIA HHHHCCCCCCHHHCC	30.54	20873877
217	Ubiquitination	IADLEEAKKLLREAV CCCHHHHHHHHHHHC	47.43	-
255	Phosphorylation	GPPGTGKTMLAKAVA CCCCCCHHHHHHHHH	20.82	24719451
280	Ubiquitination	SSSTLTSKYRGESEK CCCHHCCCCCCCHHH	33.46	-
285	Phosphorylation	TSKYRGESEKLVRLL CCCCCCCHHHHHHHH	42.74	28270605
382	Phosphorylation	RIYIPLPTAKGRAEL CCCCCCCCCCCHHHH	49.00	24719451
421	Phosphorylation	GYSGADITNVCRDAS CCCCCCHHHHHHHHH	23.34	-
440	Phosphorylation	RRRINGLSPEEIRAL HHHHCCCCHHHHHHC	31.50	30266825
473	Phosphorylation	KKIAKSVSAADLEKY HHHHHCCCHHHHHHH	25.49	26471730

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KATL1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KATL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KATL1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KATL1_HUMAN	KATNAL1	physical	25416956
KLC4_HUMAN	KLC4	physical	25416956
CE57L_HUMAN	CEP57L1	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.