CAD19_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CAD19_HUMAN
• UniProt AC: Q9H159
• Protein Name: Cadherin-19
• Gene Name: CDH19
• Organism: Homo sapiens (Human).
• Sequence Length: 772
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein.
• Protein Description: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types..
• Protein Sequence: MNCYLLLRFMLGIPLLWPCLGATENSQTKKVKQPVRSHLRVKRGWVWNQFFVPEEMNTTSHHIGQLRSDLDNGNNSFQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDIATGRAVEPESEFVIKVSDINDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNARLLYSLLQGQPYFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDMIGQPGALSGTTSVLIKLSDVNDNKPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQTFDIITNHETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVEDVDEPPLFLLPYYVFEVFEETPQGSFVGVVSATDPDNRKSPIRYSITRSKVFNINDNGTITTSNSLDREISAWYNLSITATEKYNIEQISSIPLYVQVLNINDHAPEFSQYYETYVCENAGSGQVIQTISAVDRDESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVILTNRTGFNLQEEPVFYISILIADNGIPSLTSTNTLTIHVCDCGDSGSTQTCQYQELVLSMGFKTEVIIAILICIMIIFGFIFLTLGLKQRRKQILFPEKSEDFRENIFQYDDEGGGEEDTEAFDIAELRSSTIMRERKTRKTTSAEIRSLYRQSLQVGPDSAIFRKFILEKLEEANTDPCAPPFDSLQTYAFEGTGSLAGSLSSLESAVSDQDESYDYLNELGPRFKRLACMFGSAVQSNN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MNCYLLLRFML ----CCHHHHHHHHH	8.72	-
57	N-linked_Glycosylation	FFVPEEMNTTSHHIG CCCCHHHCCCCCCHH	43.41	UniProtKB CARBOHYD
74	N-linked_Glycosylation	RSDLDNGNNSFQYKL HHHCCCCCCCEEEEE	47.42	UniProtKB CARBOHYD
111	Phosphorylation	KLDREERSLYILRAQ ECCHHHHHHHEEEEE	28.89	24719451
113	Phosphorylation	DREERSLYILRAQVI CHHHHHHHEEEEEEE	10.11	24719451
132	Phosphorylation	GRAVEPESEFVIKVS CCCCCCCCCEEEEEE	47.23	28064214
240	Phosphorylation	PGALSGTTSVLIKLS CCCCCCCEEEEEEHH	21.99	22210691
241	Phosphorylation	GALSGTTSVLIKLSD CCCCCCEEEEEEHHH	18.11	22210691
348	Phosphorylation	VPEQLMKYHTEASTT CCHHHHHHHCCCCCE	10.46	25247763
354	Phosphorylation	KYHTEASTTFIKIQV HHHCCCCCEEEEEEE	32.54	25247763
355	Phosphorylation	YHTEASTTFIKIQVE HHCCCCCEEEEEEEE	22.37	25247763
402	Phosphorylation	TDPDNRKSPIRYSIT CCCCCCCCCEEEEEE	23.48	-
407	Phosphorylation	RKSPIRYSITRSKVF CCCCEEEEEEECCEE	13.97	-
409	Phosphorylation	SPIRYSITRSKVFNI CCEEEEEEECCEEEE	23.97	-
419	N-linked_Glycosylation	KVFNINDNGTITTSN CEEEECCCCEEEECC	45.05	UniProtKB CARBOHYD
437	N-linked_Glycosylation	REISAWYNLSITATE CCCHHHEEEEEEEEC	19.33	UniProtKB CARBOHYD
508	N-linked_Glycosylation	EEHHFYFNLSVEDTN CEEEEEEECEEEECC	21.74	UniProtKB CARBOHYD
515	N-linked_Glycosylation	NLSVEDTNNSSFTII ECEEEECCCCCEEEE	59.72	UniProtKB CARBOHYD
516	N-linked_Glycosylation	LSVEDTNNSSFTIID CEEEECCCCCEEEEE	40.92	UniProtKB CARBOHYD
534	N-linked_Glycosylation	NTAVILTNRTGFNLQ CEEEEEECCCCCCCC	35.75	UniProtKB CARBOHYD
623	Acetylation	LGLKQRRKQILFPEK HCHHHHHHHHCCCCC	43.83	7492115
630	Ubiquitination	KQILFPEKSEDFREN HHHCCCCCCHHHHHH	60.42	29967540
630	Acetylation	KQILFPEKSEDFREN HHHCCCCCCHHHHHH	60.42	7492123
631	Phosphorylation	QILFPEKSEDFRENI HHCCCCCCHHHHHHC	40.51	29255136
680	Phosphorylation	TTSAEIRSLYRQSLQ CCHHHHHHHHHHHCC	35.10	28348404
685	Phosphorylation	IRSLYRQSLQVGPDS HHHHHHHHCCCCCCH	16.27	29255136
692	Phosphorylation	SLQVGPDSAIFRKFI HCCCCCCHHHHHHHH	26.80	28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CAD19_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CAD19_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CAD19_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FBSP1_HUMAN	FBXO45	physical	28514442
CSR2B_HUMAN	CSRP2BP	physical	28514442
MARK1_HUMAN	MARK1	physical	28514442
YETS2_HUMAN	YEATS2	physical	28514442
KLDC3_HUMAN	KLHDC3	physical	28514442
MYCB2_HUMAN	MYCBP2	physical	28514442
ZZZ3_HUMAN	ZZZ3	physical	28514442
TAD2A_HUMAN	TADA2A	physical	28514442
MARK3_HUMAN	MARK3	physical	28514442
DDX11_HUMAN	DDX11	physical	28514442
MBIP1_HUMAN	MBIP	physical	28514442
CO039_HUMAN	C15orf39	physical	28514442
TADA3_HUMAN	TADA3	physical	28514442
TPP2_HUMAN	TPP2	physical	28514442
LMBL2_HUMAN	L3MBTL2	physical	28514442
UBB_HUMAN	UBB	physical	28514442
SETX_HUMAN	SETX	physical	28514442
MGAP_HUMAN	MGA	physical	28514442
PUSL1_HUMAN	PUSL1	physical	28514442
TOP2A_HUMAN	TOP2A	physical	28514442
CND3_HUMAN	NCAPG	physical	28514442
MARK2_HUMAN	MARK2	physical	28514442
PML_HUMAN	PML	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.