LRRT1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LRRT1_HUMAN
• UniProt AC: Q86UE6
• Protein Name: Leucine-rich repeat transmembrane neuronal protein 1
• Gene Name: LRRTM1
• Organism: Homo sapiens (Human).
• Sequence Length: 522
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, postsynaptic cell membrane; Single-pass type I membrane protein.
• Protein Description: Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation, acting at both pre- and postsynaptic level..
• Protein Sequence: MDFLLLGLCLYWLLRRPSGVVLCLLGACFQMLPAAPSGCPQLCRCEGRLLYCEALNLTEAPHNLSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLISLHSLCLRRNKVAIVVSSLDWVWNLEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEPRILNSWKSLTSITLAGNLWDCGRNVCALASWLNNFQGRYDGNLQCASPEYAQGEDVLDAVYAFHLCEDGAEPTSGHLLSAVTNRSDLGPPASSATTLADGGEGQHDGTFEPATVALPGGEHAENAVQIHKVVTGTMALIFSFLIVVLVLYVSWKCFPASLRQLRQCFVTQRRKQKQKQTMHQMAAMSAQEYYVDYKPNHIEGALVIINEYGSCTCHQQPARECEV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
56	N-linked_Glycosylation	LLYCEALNLTEAPHN EEEEEECCCCCCCCC	52.55	UniProtKB CARBOHYD
63	N-linked_Glycosylation	NLTEAPHNLSGLLGL CCCCCCCCHHHHHHH	34.54	UniProtKB CARBOHYD
65	Phosphorylation	TEAPHNLSGLLGLSL CCCCCCHHHHHHHHH	32.48	-
71	Phosphorylation	LSGLLGLSLRYNSLS HHHHHHHHHCCCCHH	14.70	-
76	Phosphorylation	GLSLRYNSLSELRAG HHHHCCCCHHHHHCC	25.08	26270265
78	Phosphorylation	SLRYNSLSELRAGQF HHCCCCHHHHHCCCC	34.11	26270265
130	N-linked_Glycosylation	NQITQLPNTTFRPMP CCCCCCCCCCCCCCC	61.41	UniProtKB CARBOHYD
141	Phosphorylation	RPMPNLRSVDLSYNK CCCCCCCCCCCCHHH	24.13	27499020
164	Phosphorylation	FHGLRKLTTLHMRAN HHHHHHHHHHHHHHC	30.28	23663014
165	Phosphorylation	HGLRKLTTLHMRANA HHHHHHHHHHHHHCC	25.71	23663014
204	Phosphorylation	LKSLARNSFAGLFKL HHHHHHHCCHHHHHH	15.77	25003641
302	Phosphorylation	IEPRILNSWKSLTSI ECHHHHHCCCCCCEE	32.22	-
380	N-linked_Glycosylation	HLLSAVTNRSDLGPP CHHHHHCCHHHCCCC	34.56	UniProtKB CARBOHYD
476	Phosphorylation	RKQKQKQTMHQMAAM HHHHHHHHHHHHHHH	24.53	30576142
484	Phosphorylation	MHQMAAMSAQEYYVD HHHHHHHHHHHHHCC	23.29	25002506
488	Phosphorylation	AAMSAQEYYVDYKPN HHHHHHHHHCCCCCC	9.19	25002506
489	Phosphorylation	AMSAQEYYVDYKPNH HHHHHHHHCCCCCCC	6.01	25002506
492	Phosphorylation	AQEYYVDYKPNHIEG HHHHHCCCCCCCEEE	20.50	30576142

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LRRT1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LRRT1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LRRT1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AREL1_HUMAN	AREL1	physical	28514442
AT2A3_HUMAN	ATP2A3	physical	28514442
NSMA_HUMAN	SMPD2	physical	28514442
CNPY3_HUMAN	CNPY3	physical	28514442
AMGO1_HUMAN	AMIGO1	physical	28514442
MARC1_HUMAN	MARC1	physical	28514442
RAB12_HUMAN	RAB12	physical	28514442
CA043_HUMAN	C1orf43	physical	28514442
TYW1_HUMAN	TYW1	physical	28514442
NSUN3_HUMAN	NSUN3	physical	28514442
PDZD8_HUMAN	PDZD8	physical	28514442
PDE3B_HUMAN	PDE3B	physical	28514442
STIM1_HUMAN	STIM1	physical	28514442
PIGA_HUMAN	PIGA	physical	28514442
NOCT_HUMAN	CCRN4L	physical	28514442
TSN6_HUMAN	TSPAN6	physical	28514442
UPK3L_HUMAN	UPK3BL	physical	28514442
SUN1_HUMAN	SUN1	physical	28514442
CISD2_HUMAN	CISD2	physical	28514442
LRP11_HUMAN	LRP11	physical	28514442
TM131_HUMAN	TMEM131	physical	28514442
NDC1_HUMAN	NDC1	physical	28514442
LRFN3_HUMAN	LRFN3	physical	28514442
TM223_HUMAN	TMEM223	physical	28514442
K319L_HUMAN	KIAA0319L	physical	28514442
FRAS1_HUMAN	FRAS1	physical	28514442
AT131_HUMAN	ATP13A1	physical	28514442
TTC17_HUMAN	TTC17	physical	28514442
TM39A_HUMAN	TMEM39A	physical	28514442
RETST_HUMAN	RETSAT	physical	28514442
SPTC2_HUMAN	SPTLC2	physical	28514442
NGBR_HUMAN	NUS1	physical	28514442
UBE4A_HUMAN	UBE4A	physical	28514442
PCX3_HUMAN	PCNXL3	physical	28514442
OSBP1_HUMAN	OSBP	physical	28514442
CSTN1_HUMAN	CLSTN1	physical	28514442
PLPL6_HUMAN	PNPLA6	physical	28514442
TBB8_HUMAN	TUBB8	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.