ALKB8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ALKB8_HUMAN
• UniProt AC: Q96BT7
• Protein Name: Alkylated DNA repair protein alkB homolog 8
• Gene Name: ALKBH8
• Organism: Homo sapiens (Human).
• Sequence Length: 664
• Subcellular Localization: Cytoplasm . Nucleus . Predominantly cytoplasmic.
• Protein Description: Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain. [PubMed: 20123966]
• Protein Sequence: MDSNHQSNYKLSKTEKKFLRKQIKAKHTLLRHEGIETVSYATQSLVVANGGLGNGVSRNQLLPVLEKCGLVDALLMPPNKPYSFARYRTTEESKRAYVTLNGKEVVDDLGQKITLYLNFVEKVQWKELRPQALPPGLMVVEEIISSEEEKMLLESVDWTEDTDNQNSQKSLKHRRVKHFGYEFHYENNNVDKDKPLSGGLPDICESFLEKWLRKGYIKHKPDQMTINQYEPGQGIPAHIDTHSAFEDEIVSLSLGSEIVMDFKHPDGIAVPVMLPRRSLLVMTGESRYLWTHGITCRKFDTVQASESLKSGIITSDVGDLTLSKRGLRTSFTFRKVRQTPCNCSYPLVCDSQRKETPPSFPESDKEASRLEQEYVHQVYEEIAGHFSSTRHTPWPHIVEFLKALPSGSIVADIGCGNGKYLGINKELYMIGCDRSQNLVDICRERQFQAFVCDALAVPVRSGSCDACISIAVIHHFATAERRVAALQEIVRLLRPGGKALIYVWAMEQEYNKQKSKYLRGNRNSQGKKEEMNSDTSVQRSLVEQMRDMGSRDSASSVPRINDSQEGGCNSRQVSNSKLPVHVNRTSFYSQDVLVPWHLKGNPDKGKPVEPFGPIGSQDPSPVFHRYYHVFREGELEGACRTVSDVRILQSYYDQGNWCVILQKA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MDSNHQSNYK -----CCCCCHHHCC	34.61	24043423
7	Phosphorylation	-MDSNHQSNYKLSKT -CCCCCHHHCCCCHH	34.28	68742995
9	Phosphorylation	DSNHQSNYKLSKTEK CCCCHHHCCCCHHHH	20.67	29978859
14	Phosphorylation	SNYKLSKTEKKFLRK HHCCCCHHHHHHHHH	50.05	68743001
37	Phosphorylation	LRHEGIETVSYATQS HHHCCCCEEEEEECE	16.90	46162447
194	Ubiquitination	NNNVDKDKPLSGGLP CCCCCCCCCCCCCCH	54.31	29967540
197	Ubiquitination	VDKDKPLSGGLPDIC CCCCCCCCCCCHHHH	39.06	29967540
310	Phosphorylation	QASESLKSGIITSDV ECCHHHHCCCCCCCC	40.28	21406692
314	Phosphorylation	SLKSGIITSDVGDLT HHHCCCCCCCCCCEE	19.56	21406692
315	Phosphorylation	LKSGIITSDVGDLTL HHCCCCCCCCCCEEE	21.64	21406692
321	Phosphorylation	TSDVGDLTLSKRGLR CCCCCCEEECCCCCC	33.45	28555341
345	Phosphorylation	QTPCNCSYPLVCDSQ CCCCCCCCCEEECCC	11.64	50564691
351	Phosphorylation	SYPLVCDSQRKETPP CCCEEECCCCCCCCC	27.10	50564697
356	Phosphorylation	CDSQRKETPPSFPES ECCCCCCCCCCCCHH	43.46	27470641
419	Ubiquitination	DIGCGNGKYLGINKE EECCCCCCEEEECCE	41.10	-
422	Ubiquitination	CGNGKYLGINKELYM CCCCCEEEECCEEEE	20.52	-
422 (in isoform 4)	Ubiquitination	-	20.52	-
524	Phosphorylation	YLRGNRNSQGKKEEM HHCCCCCCCCCHHHH	36.75	68722543
533	Phosphorylation	GKKEEMNSDTSVQRS CCHHHHCCCHHHHHH	40.74	21406692
535	Phosphorylation	KEEMNSDTSVQRSLV HHHHCCCHHHHHHHH	30.53	21406692
536	Phosphorylation	EEMNSDTSVQRSLVE HHHCCCHHHHHHHHH	22.65	29759185
540	Phosphorylation	SDTSVQRSLVEQMRD CCHHHHHHHHHHHHH	21.48	21406692
550	Phosphorylation	EQMRDMGSRDSASSV HHHHHHCCCCCCCCC	26.69	21406692
555	Phosphorylation	MGSRDSASSVPRIND HCCCCCCCCCCCCCC	35.50	27470641
556	Phosphorylation	GSRDSASSVPRINDS CCCCCCCCCCCCCCC	35.54	27251789
563	Phosphorylation	SVPRINDSQEGGCNS CCCCCCCCCCCCCCC	26.16	24850871
570	Phosphorylation	SQEGGCNSRQVSNSK CCCCCCCCCCCCCCC	28.32	24850871
585	Phosphorylation	LPVHVNRTSFYSQDV CCEEECCCCCCCCCE	20.27	28348404
586	Phosphorylation	PVHVNRTSFYSQDVL CEEECCCCCCCCCEE	20.96	28348404
588	Phosphorylation	HVNRTSFYSQDVLVP EECCCCCCCCCEEEE	12.75	28555341
589	Phosphorylation	VNRTSFYSQDVLVPW ECCCCCCCCCEEEEE	20.21	28857561
620	Phosphorylation	PIGSQDPSPVFHRYY CCCCCCCCCHHHHHE	41.82	28555341

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ALKB8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ALKB8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ALKB8_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ALKB8_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.