MEP1A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MEP1A_HUMAN
• UniProt AC: Q16819
• Protein Name: Meprin A subunit alpha
• Gene Name: MEP1A
• Organism: Homo sapiens (Human).
• Sequence Length: 746
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Sequence: MAWIRSTCILFFTLLFAHIAAVPIKYLPEENVHDADFGEQKDISEINLAAGLDLFQGDILLQKSRNGLRDPNTRWTFPIPYILADNLGLNAKGAILYAFEMFRLKSCVDFKPYEGESSYIIFQQFDGCWSEVGDQHVGQNISIGQGCAYKAIIEHEILHALGFYHEQSRTDRDDYVNIWWDQILSGYQHNFDTYDDSLITDLNTPYDYESLMHYQPFSFNKNASVPTITAKIPEFNSIIGQRLDFSAIDLERLNRMYNCTTTHTLLDHCTFEKANICGMIQGTRDDTDWAHQDSAQAGEVDHTLLGQCTGAGYFMQFSTSSGSAEEAALLESRILYPKRKQQCLQFFYKMTGSPSDRLVVWVRRDDSTGNVRKLVKVQTFQGDDDHNWKIAHVVLKEEQKFRYLFQGTKGDPQNSTGGIYLDDITLTETPCPTGVWTVRNFSQVLENTSKGDKLQSPRFYNSEGYGFGVTLYPNSRESSGYLRLAFHVCSGENDAILEWPVENRQVIITILDQEPDVRNRMSSSMVFTTSKSHTSPAINDTVIWDRPSRVGTYHTDCNCFRSIDLGWSGFISHQMLKRRSFLKNDDLIIFVDFEDITHLSQTEVPTKGKRLSPQGLILQGQEQQVSEEGSGKAMLEEALPVSLSQGQPSRQKRSVENTGPLEDHNWPQYFRDPCDPNPCQNDGICVNVKGMASCRCISGHAFFYTGERCQAVQVHGSVLGMVIGGTAGVIFLTFSIIAILSQRPRK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
73	Phosphorylation	NGLRDPNTRWTFPIP CCCCCCCCCCCCCCC	32.73	24719451
76	Phosphorylation	RDPNTRWTFPIPYIL CCCCCCCCCCCCHHE	19.08	24719451
140	N-linked_Glycosylation	GDQHVGQNISIGQGC CCCCCCCCCEECCCC	24.85	UniProtKB CARBOHYD
222	N-linked_Glycosylation	QPFSFNKNASVPTIT CCCCCCCCCCCCEEE	38.25	UniProtKB CARBOHYD
258	N-linked_Glycosylation	ERLNRMYNCTTTHTL HHHHHHHCCCCCCHH	13.81	UniProtKB CARBOHYD
414	N-linked_Glycosylation	GTKGDPQNSTGGIYL CCCCCCCCCCCCEEE	47.10	UniProtKB CARBOHYD
440	N-linked_Glycosylation	TGVWTVRNFSQVLEN CCEEEECCHHHHHHC	36.26	UniProtKB CARBOHYD
447	N-linked_Glycosylation	NFSQVLENTSKGDKL CHHHHHHCCCCCCCC	45.55	UniProtKB CARBOHYD
460	Phosphorylation	KLQSPRFYNSEGYGF CCCCCCEECCCCCCE	21.04	25907765
462	Phosphorylation	QSPRFYNSEGYGFGV CCCCEECCCCCCEEE	22.48	25907765
465	Phosphorylation	RFYNSEGYGFGVTLY CEECCCCCCEEEEEC	12.77	25907765
470	Phosphorylation	EGYGFGVTLYPNSRE CCCCEEEEECCCCCC	22.43	25907765
472	Phosphorylation	YGFGVTLYPNSRESS CCEEEEECCCCCCCC	7.33	-
481	Phosphorylation	NSRESSGYLRLAFHV CCCCCCCEEEEEEEE	7.21	-
522	Phosphorylation	PDVRNRMSSSMVFTT CCHHHHCCCCEEEEC	18.94	30631047
523	Phosphorylation	DVRNRMSSSMVFTTS CHHHHCCCCEEEECC	17.07	30631047
524	Phosphorylation	VRNRMSSSMVFTTSK HHHHCCCCEEEECCC	16.20	30631047
528	Phosphorylation	MSSSMVFTTSKSHTS CCCCEEEECCCCCCC	20.81	22210691
529	Phosphorylation	SSSMVFTTSKSHTSP CCCEEEECCCCCCCC	23.77	-
530	Phosphorylation	SSMVFTTSKSHTSPA CCEEEECCCCCCCCC	29.15	-
539	N-linked_Glycosylation	SHTSPAINDTVIWDR CCCCCCCCCEEEECC	40.79	UniProtKB CARBOHYD
562	Phosphorylation	TDCNCFRSIDLGWSG CCCCCCCCCCCCCCC	10.53	22210691
572	Phosphorylation	LGWSGFISHQMLKRR CCCCCHHHHHHHHCH	12.85	-
580	Phosphorylation	HQMLKRRSFLKNDDL HHHHHCHHHHCCCCE	38.68	24719451
741	Phosphorylation	FSIIAILSQRPRK-- HHHHHHHCCCCCC--	20.31	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MEP1A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MEP1A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MEP1A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NPY_HUMAN	NPY	physical	11278902
NEUT_HUMAN	NTS	physical	11278902
GON1_HUMAN	GNRH1	physical	11278902
PTHY_HUMAN	PTH	physical	11278902
VIP_HUMAN	VIP	physical	11278902
LAMA5_HUMAN	LAMA5	physical	10620696
LAMA1_HUMAN	LAMA1	physical	10620696
MEP1A_HUMAN	MEP1A	physical	11301339
FINC_HUMAN	FN1	physical	8063866
KNG1_HUMAN	KNG1	physical	11278902

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.