GON1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GON1_HUMAN
• UniProt AC: P01148
• Protein Name: Progonadoliberin-1
• Gene Name: GNRH1
• Organism: Homo sapiens (Human).
• Sequence Length: 92
• Subcellular Localization: Secreted.
• Protein Description: Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones..
• Protein Sequence: MKPIQKLLAGLILLTWCVEGCSSQHWSYGLRPGGKRDAENLIDSFQEIVKEVGQLAETQRFECTTHQPRSPLRDLKGALESLIEEETGQKKI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Pyrrolidone_carboxylic_acid	CVEGCSSQHWSYGLR HHHHHHCCCCCCCCC	26.27	-
24	Pyrrolidone_carboxylic_acid	CVEGCSSQHWSYGLR HHHHHHCCCCCCCCC	26.27	6760865
24	Pyrrolidone_carboxylic_acid	CVEGCSSQHWSYGLR HHHHHHCCCCCCCCC	26.27	6760865
33	Glycine amide	WSYGLRPGGKRDAEN CCCCCCCCCCCHHHH	48.06	-
33	Amidation	WSYGLRPGGKRDAEN CCCCCCCCCCCHHHH	48.06	6760865

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GON1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GON1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GON1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MTX1_HUMAN	MTX1	physical	28514442
TRI68_HUMAN	TRIM68	physical	28514442
MASU1_HUMAN	MALSU1	physical	28514442
EMC8_HUMAN	EMC8	physical	28514442
EMC3_HUMAN	EMC3	physical	28514442
EMC4_HUMAN	EMC4	physical	28514442
GRP78_HUMAN	HSPA5	physical	28514442

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• 614841: Hypogonadotropic hypogonadism 12 with or without anosmia (HH12)
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Amidation

"The chemical identity of the immunoreactive LHRH-like peptidebiosynthesized in the human placenta.";
Tan L., Rousseau P.;
Biochem. Biophys. Res. Commun. 109:1061-1071(1982).
Cited for: PROTEIN SEQUENCE OF 24-33.
PubMed: 6760865

Pyrrolidone carboxylic acid

"The chemical identity of the immunoreactive LHRH-like peptidebiosynthesized in the human placenta.";
Tan L., Rousseau P.;
Biochem. Biophys. Res. Commun. 109:1061-1071(1982).
Cited for: PROTEIN SEQUENCE OF 24-33.
PubMed: 6760865