dbPTM

GRM3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GRM3_HUMAN
UniProt AC	Q14832
Protein Name	Metabotropic glutamate receptor 3
Gene Name	GRM3
Organism	Homo sapiens (Human).
Sequence Length	879
Subcellular Localization	Cell membrane Multi-pass membrane protein .
Protein Description	G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity..
Protein Sequence	MKMLTRLQVLTLALFSKGFLLSLGDHNFLRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRANASFTWVASDGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRRVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKYSYLKVGHWAETLSLDVNSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLADEFTCMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIKHNNTPLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALLTKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPGTRRYTLAEKRETVILKCNVKDSSMLISLTYDVILVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIILFQPQKNVVTHRLHLNRFSVSGTGTTYSQSSASTYVPTVCNGREVLDSTTSSL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	LTRLQVLTLALFSKG HHHHHHHHHHHHHHC	15.89	23663014
16	Phosphorylation	VLTLALFSKGFLLSL HHHHHHHHHCCHHHC	32.49	23663014
209	N-linked_Glycosylation	AEILRFFNWTYVSTV HHHHHHCCCEEEEEC	27.71	UniProtKB CARBOHYD
243	Phosphorylation	LRNICIATAEKVGRS HHCHHHHHHHHHCCC	18.55	22985185
255	Phosphorylation	GRSNIRKSYDSVIRE CCCHHHHHHHHHHHH	25.07	-
266	Ubiquitination	VIRELLQKPNARVVV HHHHHHCCCCCEEEE	39.96	-
292	N-linked_Glycosylation	IAAASRANASFTWVA HHHHHHCCCEEEEEE	34.70	UniProtKB CARBOHYD
294	Phosphorylation	AASRANASFTWVASD HHHHCCCEEEEEECC	24.02	26853621
308	Phosphorylation	DGWGAQESIIKGSEH CCCCCCCHHCCCCCC	19.96	24719451
410	Phosphorylation	ALHKMQRTLCPNTTK HHHHHHHHHCCCHHH	18.80	27174698
414	N-linked_Glycosylation	MQRTLCPNTTKLCDA HHHHHCCCHHHHHHH	60.42	UniProtKB CARBOHYD
415	Phosphorylation	QRTLCPNTTKLCDAM HHHHCCCHHHHHHHH	15.51	27174698
416	Phosphorylation	RTLCPNTTKLCDAMK HHHCCCHHHHHHHHH	28.76	27174698
439	N-linked_Glycosylation	KDYLLKINFTAPFNP CEEEEEEEEECCCCC	26.99	UniProtKB CARBOHYD
466	Phosphorylation	FGDGMGRYNVFNFQN CCCCCCCEEEEEEEC	15.22	22817900
478	Phosphorylation	FQNVGGKYSYLKVGH EECCCCCEEEEEECC	13.06	22817900
480	Phosphorylation	NVGGKYSYLKVGHWA CCCCCEEEEEECCEE	13.88	22817900
743	Phosphorylation	SMLISLTYDVILVIL HHHHHHHHHHHHHHH	17.32	17053785
754	Phosphorylation	LVILCTVYAFKTRKC HHHHHHHHHHHCCCC	6.54	17053785
758	Phosphorylation	CTVYAFKTRKCPENF HHHHHHHCCCCCCCC	28.98	-
810	Phosphorylation	MCISVSLSGFVVLGC EEEEEECCCCHHEEH	23.76	24719451
845	Dephosphorylation	RLHLNRFSVSGTGTT EEEECEEEEECCCCE	16.49	14663150

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of GRM3_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of GRM3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GRM3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PPM1A_HUMAN	PPM1A	physical	14663150
GRIP1_HUMAN	GRIP1	physical	11891216
PICK1_HUMAN	PICK1	physical	11891216
SDCB1_HUMAN	SDCBP	physical	11891216

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D09008	Talaglumetad hydrochloride (USAN)
D09949	Pomaglumetad methionil (USAN/INN)
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GRM3_HUMAN

Related Literatures of Post-Translational Modification